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Superoxide Mediates Sympathoexcitation in Heart Failure: Roles of Angiotensin II and NAD(P)H Oxidase
Chronic heart failure (CHF) is often associated with excitation of the sympathetic nervous system. This event is thought to be a negative predictor of survival in CHF. Sympathoexcitation and central… Expand
Novel Mechanisms of Sympathetic Regulation in Chronic Heart Failure
- I. Zucker
- 1 December 2006
The idea that activation of the sympathetic nervous system is part and parcel of the apparent positive feedback cycle of cardiac deterioration in the setting of chronic heart failure (CHF) is not a… Expand
Simvastatin Therapy Normalizes Sympathetic Neural Control in Experimental Heart Failure: Roles of Angiotensin II Type 1 Receptors and NAD(P)H Oxidase
Background—In a previous study, we showed that simvastatin (SIM) therapy normalized sympathetic outflow and cardiovascular reflex regulation in chronic heart failure (CHF). However, the precise… Expand
The origin of sympathetic outflow in heart failure: the roles of angiotensin II and nitric oxide.
- I. Zucker, H. Schultz, Yi-fan Li, Y. Wang, W. Wang, K. Patel
- Progress in biophysics and molecular biology
- 1 February 2004
The regulation of sympathetic nerve activity in chronic heart failure (CHF) has been an area of renewed investigation. Understanding the central mechanisms that are responsible for… Expand
The temporal relationship between the development of heart failure and activation of the neurohumoral systems involved in chronic heart failure (CHF) has not been precisely defined. When a… Expand
NADPH oxidase-derived reactive oxygen species in skeletal muscle modulates the exercise pressor reflex.
- Han-Jun Wang, Yan-Xia Pan, W. Wang, I. Zucker, W. Wang
- Chemistry, Medicine
- Journal of applied physiology
- 4 June 2009
Muscle metabolic by-products during exercise, such as K+, lactic acid, ATP, H+, and phosphate, are well established to be involved in the reflex cardiovascular response to static muscle contraction.… Expand
Neural regulation of sympathetic nerve activity in heart failure.
- I. Zucker, W. Wang, M. Braendle, H. Schultz, K. Patel
- Progress in cardiovascular diseases
- 1 May 1995
One of the hallmarks of chronic congestive heart failure is an increase in sympathetic tone to the peripheral circulation and to the heart. A correlation between plasma norepinephrine and the… Expand
AT1 receptor mRNA antisense normalizes enhanced cardiac sympathetic afferent reflex in rats with chronic heart failure.
- G. Zhu, Lie Gao, Y. Li, K. Patel, I. Zucker, W. Wang
- American journal of physiology. Heart and…
- 1 October 2004
Previous studies showed that the cardiac sympathetic afferent reflex (CSAR) is enhanced in dogs and rats with chronic heart failure (CHF) and that central ANG II type 1 receptors (AT(1)R) are… Expand
Exercise Training Normalizes Sympathetic Outflow by Central Antioxidant Mechanisms in Rabbits With Pacing-Induced Chronic Heart Failure
Background— In a recent study, we demonstrated that an increase in oxidative stress in the rostral ventrolateral medulla plays a critical role in the sympathoexcitation observed in chronic heart… Expand
Electrophysiology of rabbit ventricular myocytes following sustained rapid ventricular pacing.
- G. Rozanski, Z. Xu, R. Whitney, H. Murakami, I. Zucker
- Biology, Medicine
- Journal of molecular and cellular cardiology
- 1 February 1997
The present study examined changes in electrophysiological properties of ventricular myocytes isolated from rabbit hearts after 2-3 weeks of rapid ventricular pacing. Left ventricular end-diastolic… Expand