GCLM gene

Known as: GCLM, GLUTAMATE-CYSTEINE LIGASE, REGULATORY, gamma-glutamylcysteine synthetase 
This gene is involved in the detoxification of endogenous reactive oxygen species. It also plays a role in drug and xenobiotic metabolism.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Oxidative stress has been implicated in the development of vascular disease and in the promotion of endothelial dysfunction via… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2009
2009
BACKGROUND Experimental evidences show that glutathione and its rate-limiting synthesizing enzyme, the glutamate-cysteine ligase… (More)
  • table 1
  • figure 1
  • table 2
  • table 3
  • table 4
Is this relevant?
2009
2009
Inorganic arsenic is an environmental contaminant toxic for key immune cells. We recently reported that low micromolar… (More)
Is this relevant?
2008
2008
BACKGROUND Exposure to toxic methylmercury (MeHg) through fish consumption is a large problem worldwide, and it has led to… (More)
  • table 1
  • table 2
  • figure 2
  • table 3
  • figure 3
Is this relevant?
2007
2007
Vanillin (VAN) and cinnamaldehyde (CIN) are dietary flavorings that exhibit antimutagenic activity against mutagen-induced and… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Glutamate-cysteine ligase (GCL) is the rate-limiting enzyme in the GSH biosynthesis pathway. In higher eukaryotes, this enzyme is… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
BACKGROUND Human glutamate-cysteine ligase (GCL) is a rate-limiting enzyme for the synthesis of glutathione that plays a crucial… (More)
  • figure 2
  • figure 1
  • table 2
  • figure 3
  • table 3
Is this relevant?
2002
2002
Constitutive and inducible expression of the gene encoding the modulator subunit of human glutamate-cysteine ligase (GCLM) is… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
The biosynthesis of reduced glutathione (GSH) is carried out by the enzymes gamma-glutamylcysteine synthetase (GCL) and GSH… (More)
Is this relevant?
2000
2000
Exposure of cells to toxic chemical species can result in reduced glutathione (GSH) depletion, generation of free radicals, and… (More)
Is this relevant?