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GCLM gene

Known as: GCLM, GLUTAMATE-CYSTEINE LIGASE, REGULATORY, gamma-glutamylcysteine synthetase 
This gene is involved in the detoxification of endogenous reactive oxygen species. It also plays a role in drug and xenobiotic metabolism.
National Institutes of Health

Related topics

Related topics

7 relations
GCLC protein, humanGCLM protein, humanGlutamate-Cysteine LigaseMetabolic Detoxication, Drug

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GCLM wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
GSH Synthetic Analogue O-Methyl-L-Tyrosinylglutathione Regulates Nrf2-Mediated Expression of GCLc and GCLm
A glutathione (L-γ-glutamyl-L-cysteinylglycine, GSH) analogue, UPF1 (O-methyl-L-tyrosinylglutathione), has been shown to increase… 
2016
2016
Alterations in glutamate cysteine ligase content in the retina of two retinitis pigmentosa animal models.
2013
2013
The Glutathione Synthesis Gene Gclm Modulates Amphiphilic Polymer-Coated CdSe/ZnS Quantum Dot–Induced Lung Inflammation in Mice
Quantum dots (QDs) are unique semi-conductor fluorescent nanoparticles with potential uses in a variety of biomedical… 
2011
2011
Gain and Loss of Function for Glutathione Synthesis: Impact on Advanced Atherosclerosis in Apolipoprotein E–Deficient Mice
Objective—Glutamate-cysteine ligase (GCL) is the rate-limiting step in glutathione synthesis. The enzyme is a heterodimer… 
2011
2011
Behavioral Characterization of GCLM-Knockout Mice, a Model for Enhanced Susceptibility to Oxidative Stress
Glutathione (GSH) is a major player in cellular defense against oxidative stress. Deletion of the modifier subunit of glutamate… 
2010
2010
Glutathione deficient C57BL/6J mice are not sensitized to ozone-induced lung injury.
2007
2007
Interaction between the catalytic and modifier subunits of glutamate-cysteine ligase.
2003
2003
Elucidation of correspondence between swine chromosome 4 and human chromosome 1 by assigning 27 genes to the ImpRH map, and development of microsatellites in the proximity of 14 genes
Loci affecting swine intramuscular fat content, backfat thickness, carcass weight, and daily weight gain were assigned to regions… 
2003
2003
Regulation of Nrf2-mediated Induction of Glutamate Cysteine Ligase Modulatory Gene (GCLM) expression: Considerations for future studies
The article highlighted in this issue is Erk Activation is Required for Nrf2 Nuclear Localization during Pyrrolidine… 
2001
2001
Cloning and analysis of the rat glutamate-cysteine ligase modifier subunit promoter.
Glutamate-cysteine ligase (GCL), the rate-limiting enzyme in glutathione (GSH) synthesis, is made up of two subunits, a catalytic… 
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