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GCLM gene

Known as: GCLM, GLUTAMATE-CYSTEINE LIGASE, REGULATORY, gamma-glutamylcysteine synthetase 
This gene is involved in the detoxification of endogenous reactive oxygen species. It also plays a role in drug and xenobiotic metabolism.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Autism is a neurodevelopmental disorder associated with social deficits and behavioral abnormalities. Recent evidence in autism… Expand
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2011
2011
Aim:To explore whether glutathione (GSH) increased through Nrf-2 activation is involved in the cytoprotective effects of carnosol… Expand
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Highly Cited
2010
Highly Cited
2010
Glutamate cysteine ligase (GCL) catalyzes the rate-limiting step in the formation of the cellular antioxidant glutathione (GSH… Expand
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2010
2010
Cytokine-activated inhibitor of κB kinase β (IKKβ) is a key mediator of immune and inflammatory responses, but recent studies… Expand
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Highly Cited
2008
Highly Cited
2008
Recent studies revealed that the herb Andrographis paniculata possesses cardioprotective activities. Using neonatal rat… Expand
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Highly Cited
2002
Highly Cited
2002
Glutamate-cysteine ligase (GCL) is the rate-limiting enzyme in the GSH biosynthesis pathway. In higher eukaryotes, this enzyme is… Expand
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Highly Cited
2002
Highly Cited
2002
Glutathione (GSH) is a ubiquitous antioxidant in lung epithelial cells and lung lining fluid. Transforming growth factor β1 (TGF… Expand
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Highly Cited
2002
Highly Cited
2002
Glutamate-cysteine ligase (GCL) plays an important role in regulating glutathione homeostasis. In mammals, it comprises a… Expand
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Highly Cited
2002
Highly Cited
2002
Constitutive and inducible expression of the gene encoding the modulator subunit of human glutamate-cysteine ligase (GCLM) is… Expand
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Highly Cited
2000
Highly Cited
2000
The biosynthesis of reduced glutathione (GSH) is carried out by the enzymes gamma-glutamylcysteine synthetase (GCL) and GSH… Expand
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