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Glutamate-Cysteine Ligase

Known as: EC 6.3.2.2, Gamma-Glutamylcysteinyl Synthetase, Gamma-Glutamylcysteine Synthetase 
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme… 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Oxidative stress plays an important role in obesity-related metabolic diseases. Glutathione peroxidase (GPX) is an antioxidant… 
Highly Cited
1998
Highly Cited
1998
Overexpression of Bcl-2 and related anti-apoptotic gene products has been shown to increase the intracellular concentration of… 
Highly Cited
1997
Highly Cited
1997
We have shown that in HepG2 cells treatment with 75 microM t-butylhydroquinone (tBHQ) results in a 2.5-fold increase in… 
Highly Cited
1996
Highly Cited
1996
The structural gene for glyoxalase I (GLO1) of Saccharomyces cerevisiae was identified. The GLO1 gene contained an open reading… 
Highly Cited
1996
Highly Cited
1996
We have recently shown that multidrug resistance-associated protein (MRP) and gamma-glutamylcysteine synthetase (gamma-GCS) heavy… 
Highly Cited
1996
Highly Cited
1996
The tripeptide y-L-glutamyl+cystinylglycine (glutathione) is one of the major antioxidant molecules of cells and is thought to… 
Highly Cited
1994
Highly Cited
1994
Glutathione-dependent defense against xenobiotic toxicity is a multifaceted phenomenon that has been well characterized in… 
Highly Cited
1985
Highly Cited
1985
The role of glutathione (GSH) in lectin-induced lymphocyte activation can be studied by quantitating lectin-induced nuclear size…