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Glutamate-Cysteine Ligase
Known as:
EC 6.3.2.2
, Gamma-Glutamylcysteinyl Synthetase
, Gamma-Glutamylcysteine Synthetase
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Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme…
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National Institutes of Health
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Related topics
Related topics
17 relations
Buthionine Sulfoximine
GCLC protein, human
GCLM gene
Gamma glutamyl cysteine synthetase:CCnc:Pt:RBC:Qn
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Narrower (3)
GCLC protein, rat
GCLM protein, human
GSH1 protein, S cerevisiae
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Dysregulated glutathione metabolism links to impaired insulin action in adipocytes.
Hironori Kobayashi
,
M. Matsuda
,
A. Fukuhara
,
R. Komuro
,
I. Shimomura
American Journal of Physiology. Endocrinology and…
2009
Corpus ID: 2928726
Oxidative stress plays an important role in obesity-related metabolic diseases. Glutathione peroxidase (GPX) is an antioxidant…
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Highly Cited
1998
Highly Cited
1998
Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux.
M. Meredith
,
Carrie L. Cusick
,
S. R. Soltaninassab
,
Konjeti S. Sekhar
,
Shelly C. Lu
,
Michael L. Freeman
Biochemical and Biophysical Research…
1998
Corpus ID: 25403964
Overexpression of Bcl-2 and related anti-apoptotic gene products has been shown to increase the intracellular concentration of…
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Highly Cited
1997
Highly Cited
1997
Regulation of human gamma-glutamylcysteine synthetase: co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells.
C. Galloway
,
G. Blake
,
A. Shepherd
,
I. Lesley McLELLAN
Biochemical Journal
1997
Corpus ID: 5776924
We have shown that in HepG2 cells treatment with 75 microM t-butylhydroquinone (tBHQ) results in a 2.5-fold increase in…
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Highly Cited
1996
Highly Cited
1996
Identification of the Structural Gene for Glyoxalase I from Saccharomyces cerevisiae*
Y. Inoue
,
A. Kimura
Journal of Biological Chemistry
1996
Corpus ID: 8400234
The structural gene for glyoxalase I (GLO1) of Saccharomyces cerevisiae was identified. The GLO1 gene contained an open reading…
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Highly Cited
1996
Highly Cited
1996
Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers.
M. Kuo
,
J. Bao
,
+4 authors
Toshihisa Ishikawa
Cancer Research
1996
Corpus ID: 30079863
We have recently shown that multidrug resistance-associated protein (MRP) and gamma-glutamylcysteine synthetase (gamma-GCS) heavy…
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Highly Cited
1996
Highly Cited
1996
Glutathione is an important antioxidant molecule in the yeast
D. Jamieson
1996
Corpus ID: 260635903
The tripeptide y-L-glutamyl+cystinylglycine (glutathione) is one of the major antioxidant molecules of cells and is thought to…
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Highly Cited
1994
Highly Cited
1994
Glutathione-dependent defense in channel catfish (Ictalurus punctatus) and brown bullhead (Ameriurus nebulosus).
B. Hasspieler
,
J. V. Behar
,
R. Di Giulio
Ecotoxicology and Environmental Safety
1994
Corpus ID: 21266401
Glutathione-dependent defense against xenobiotic toxicity is a multifaceted phenomenon that has been well characterized in…
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Highly Cited
1989
Highly Cited
1989
Protective role of intracellular glutathione against oxidized low density lipoprotein in cultured endothelial cells.
M. Kuzuya
,
M. Naito
,
C. Funaki
,
T. Hayashi
,
K. Asai
,
F. Kuzuya
Biochemical and Biophysical Research…
1989
Corpus ID: 32552541
Highly Cited
1985
Highly Cited
1985
The role of glutathione in lymphocyte activation. I. Comparison of inhibitory effects of buthionine sulfoximine and 2-cyclohexene-1-one by nuclear size transformation.
D. Hamilos
,
H. Wedner
Journal of Immunology
1985
Corpus ID: 24914891
The role of glutathione (GSH) in lectin-induced lymphocyte activation can be studied by quantitating lectin-induced nuclear size…
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Highly Cited
1977
Highly Cited
1977
gamma-Glutamylcysteine synthetase. Further purification, "half of the sites" reactivity, subunits, and specificity.
R. Sekura
,
A. Meister
Journal of Biological Chemistry
1977
Corpus ID: 24898468
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