Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Glutamate-Cysteine Ligase

Known as: EC 6.3.2.2, Gamma-Glutamylcysteinyl Synthetase, Gamma-Glutamylcysteine Synthetase 
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Glutathione (GSH) is a tripeptide composed of glutamate, cysteine, and glycine. The first and rate-limiting step in GSH synthesis… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Glutamate cysteine ligase (GCL), which synthesizes γ-glutamyl-cysteine (γ-GC), is the rate-limiting enzyme in GSH biosynthesis… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Electrophiles formed during metabolic activation of chemical carcinogens and reactive oxygen species generated from endogenous… Expand
Is this relevant?
Review
2001
Review
2001
Oxidative stress is involved in the aetiology of defective embryo development. Reactive oxygen species (ROS) may originate from… Expand
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Nrf2, which belongs to the basic leucine zipper (bZip) transcription factor family, has been implicated as a key molecule… Expand
  • table 1
  • figure 1
  • table 2
  • figure 2
  • table 3
Is this relevant?
Review
1999
Review
1999
  • O. Griffith
  • Free radical biology & medicine
  • 1999
  • Corpus ID: 22579329
Glutathione (L-gamma-glutamyl-L-cysteinylglycine, GSH) is synthesized from its constituent amino acids by the sequential action… Expand
Is this relevant?
Review
1999
Review
1999
  • S. Lu
  • FASEB journal : official publication of the…
  • 1999
  • Corpus ID: 8338328
Glutathione (GSH) is an important intracellular peptide with multiple functions ranging from antioxidant defense to modulation of… Expand
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Glutathione plays a pivotal role in protecting plants from environmental stresses, oxidative stress, xenobiotics, and some heavy… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Review
1991
Review
1991
  • A. Meister
  • Pharmacology & therapeutics
  • 1991
  • Corpus ID: 40681111
Glutathione, which is synthesized within cells, is a component of a pathway that uses NADPH to provide cells with their reducing… Expand
Is this relevant?
Highly Cited
1979
Highly Cited
1979
Buthionine sulfoximine (S-n-butyl homocysteine sulfoximine), the most potent of a series of analogs of methionine sulfoximine… Expand
  • figure 1
  • figure 2
  • table I
Is this relevant?