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  • Yi Yang, Matthew Z. Dieter, Ying Chen, Howard G. Shertzer, Daniel W. Nebert, Timothy P. Dalton
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2002 (First Publication: 20 December 2002)
  • Glutamate-cysteine ligase (GCL) is the rate-limiting enzyme in the GSH biosynthesis pathway. In higher eukaryotes, this enzyme is a heterodimer comprising a catalytic subunit (GCLC) and a modifierExpand
  • Brenton Wallin, Birgitta Rosengren, Howard G. Shertzer, Germán Camejo
  • Chemistry, Medicine
  • Analytical biochemistry
  • 1993
  • Transition metals catalyze free radical-mediated oxidation of lipids and lipoproteins. This process is currently studied because of its potential relevance to pathological processes likeExpand
  • S. Uno, T. Dalton, +6 authors D. Nebert
  • Chemistry, Medicine
  • Molecular Pharmacology
  • 2006 (First Publication: 1 April 2006)
  • CYP1A1 and CYP1B1 metabolically activate many polycyclic aromatic hydrocarbons (PAHs), including benzo[a]pyrene, to reactive intermediates associated with toxicity, mutagenesis, and carcinogenesis.Expand