GCLM protein, human

Known as: GLCLR, Glutamate--Cysteine Ligase Modifier Subunit, Glutamate--Cysteine Ligase Regulatory Subunit 
Widely expressed (skeletal muscle highest) by human GCLM Gene (Aldo/Keto Reductase Family), 274-aa 31-kDa Gamma-Glutamylcysteine Synthetase… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Accruing data suggest that oxidative stress may be a factor underlying the pathophysiology of bipolar disorder (BD), major… (More)
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Highly Cited
2004
Highly Cited
2004
Hydrogen sulfide (H2S), which is a well-known toxic gas, is found in relatively high concentrations in the brain. Although a… (More)
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Review
2004
Review
2004
Glutathione (gamma-glutamyl-cysteinyl-glycine; GSH) is the most abundant low-molecular-weight thiol, and GSH/glutathione… (More)
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Highly Cited
2002
Highly Cited
2002
Electrophiles formed during metabolic activation of chemical carcinogens and reactive oxygen species generated from endogenous… (More)
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Review
2000
Review
2000
Induction of Phase 2 enzymes is an effective and sufficient strategy for achieving protection against the toxic and neoplastic… (More)
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Highly Cited
1999
Highly Cited
1999
Glutathione (GSH), a major antioxidant in most aerobic organisms, is perceived to be particularly important in plant chloroplasts… (More)
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Highly Cited
1999
Highly Cited
1999
In the present study, we show that melatonin induces the expression of gamma-glutamylcysteine synthetase (gamma-GCS), the rate… (More)
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Highly Cited
1998
Highly Cited
1998
Glutathione plays a pivotal role in protecting plants from environmental stresses, oxidative stress, xenobiotics, and some heavy… (More)
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Highly Cited
1997
Highly Cited
1997
Lipoic acid (thiotic acid) is being used as a dietary supplement, and as a therapeutic agent, and is reported to have beneficial… (More)
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Highly Cited
1979
Highly Cited
1979
Glutathione is translocated out of cells; cells that have membrane-bound gamma-glutamyl transpeptidase can utilize translocated… (More)
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