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A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
Increasing attention has focused on the role of free radicals derived from oxygen in the pathophysiology of a wide variety of disorders. One of the well-recognized targets of free radical-inducedExpand
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Deletion of Selenoprotein P Alters Distribution of Selenium in the Mouse*
Selenoprotein P (Se-P) contains most of the selenium in plasma. Its function is not known. Mice with the Se-P gene deleted (Sepp −/−) were generated. Two phenotypes were observed: 1) Sepp −/−miceExpand
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Selenoprotein P-expression, functions, and roles in mammals.
  • R. Burk, K. Hill
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 1 November 2009
Selenoprotein P (Sepp1) is a secreted protein that is made up of 2 domains. The larger N-terminal domain contains 1 selenocysteine residue in a redox motif and the smaller C-terminal domain containsExpand
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Effectiveness of selenium supplements in a low-selenium area of China.
BACKGROUND Selenium is an essential micronutrient with a recommended dietary allowance for adults of 55 mug/d. It functions as an essential constituent of selenoproteins. Although there is noExpand
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An estimation of selenium requirements for New Zealanders.
BACKGROUND Current US dietary recommendations for selenium are based on maximization of plasma glutathione peroxidase (GSHPx) activity according to data from one study of Chinese men. OBJECTIVE TheExpand
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Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender‐specific manner (the SELGEN study)
Selenium (Se), a micronutrient essential for human health, is incorporated into at least 25 selenoproteins including selenoprotein P (SePP)′ which transports Se within the body. This researchExpand
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Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis.
  • R. Burk, K. Hill
  • Biology, Medicine
  • Annual review of nutrition
  • 12 July 2005
Selenoprotein P is an abundant extracellular glycoprotein that is rich in selenocysteine. It has two domains with respect to selenium content. The N-terminal domain of the rat protein contains oneExpand
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Effects of Chemical Form of Selenium on Plasma Biomarkers in a High-Dose Human Supplementation Trial
Intervention trials with different forms of selenium are under way to assess the effects of selenium supplements on the incidence of cancer and other diseases. Plasma selenium biomarkers respond toExpand
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Regulation of Selenium Metabolism and Transport.
  • R. Burk, K. Hill
  • Biology, Medicine
  • Annual review of nutrition
  • 17 July 2015
Selenium is regulated in the body to maintain vital selenoproteins and to avoid toxicity. When selenium is limiting, cells utilize it to synthesize the selenoproteins most important to them, creatingExpand
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Deletion of Apolipoprotein E Receptor-2 in Mice Lowers Brain Selenium and Causes Severe Neurological Dysfunction and Death When a Low-Selenium Diet Is Fed
Selenoprotein P (Sepp1) is a plasma and extracellular protein that is rich in selenium. Deletion of Sepp1 results in sharp decreases of selenium levels in the brain and testis with dysfunction ofExpand
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