K. Hill

Publications175
h-index61
Citations12,959
Highly Influential Citations420
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A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.
TLDR
It is found that a series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase mechanism involving free radical-catalyzed peroxidation of arachidonic acid, and that these prostanoids may participate as pathophysiological mediators in oxidant injury.
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Selenoprotein P-expression, functions, and roles in mammals.
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Deletion of Selenoprotein P Alters Distribution of Selenium in the Mouse*
TLDR
The results suggest that Se-P from liver provides selenium to several tissues, especially testis and brain, and indicate that transport forms of seenium other than Se-p exist because selenia levels of all tissues except testis responded to increases of dietary selenIUM in Sepp −/− mice.
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Effectiveness of selenium supplements in a low-selenium area of China.
TLDR
It is suggested that selenoprotein P is a better indicator of selenium nutritional status than is glutathione peroxidase and that the recommended dietary allowance of Selenium, which was set with the use of glutathion peroxIDase as the index of seenium status, should be revised.
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An estimation of selenium requirements for New Zealanders.
TLDR
An upper estimated requirement of 90 microgram Se/d was calculated as the intake necessary for maximization of plasma GSHPx activity, as used in the derivation of the US recommended daily allowance, but the upper estimate could be achieved only with regular inclusion of high-selenium foods.
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Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis.
TLDR
Selenoprotein P binds to endothelial cells in the rat, and plasma levels of the protein correlate with prevention of diquat-induced lipid peroxidation and hepatic endothelial cell injury, indicating that plasma selenop protein P is the better index of human selenium nutritional status.
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Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender‐specific manner (the SELGEN study)
TLDR
Two common functional SNPs within the human SePP gene that may predict behavior of biomarkers of Se status and response to supplementation and thus susceptibility to disease are revealed.
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Regulation of selenoproteins.
TLDR
The selenoproteins most sensitive to selenium deficiency is liver cGSH-Px, and decreased synthesis of it under deficiency conditions might serve to increase theselenium available for synthesis of seleniproteins that are more important to the survival of the animal than is cG SHPx.
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Effects of Chemical Form of Selenium on Plasma Biomarkers in a High-Dose Human Supplementation Trial
TLDR
Selenium in the form of selenomethionine is better absorbed than selenite, and plasma selenium concentration is useful in monitoring compliance and safety ofselenium supplementation as selenometrichionines but not as seenite.
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Regulation of Selenium Metabolism and Transport.
TLDR
The regulated whole-body pool of selenium is shifted to needy cells and then to vital selenoproteins in them to supply seenium where it is needed, creating a whole- body seleniprotein hierarchy.
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