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GCLC protein, human

Known as: EC 6.3.2.2, Glutamate-Cysteine Ligase Catalytic Subunit, Gamma-Glutamylcysteine Synthetase Catalytic Subunit 
Glutamate-cysteine ligase catalytic subunit (637 aa, ~73 kDa) is encoded by the human GCLC gene. This protein is involved in the biosynthesis of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
BackgroundCarbonic anhydrase IX is a hypoxia-induced enzyme that has many biologically important functions, including its role in… Expand
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Review
2005
Review
2005
In this paper, we summarize the data obtained in our laboratory showing the effects of glucocorticoids on human cognitive… Expand
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Highly Cited
2004
Highly Cited
2004
Glutathione (GSH) significantly declines in the aging rat liver. Because GSH levels are partly a reflection of its synthetic… Expand
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Highly Cited
2002
Highly Cited
2002
Glutamate-cysteine ligase (GCL) is the rate-limiting enzyme in the GSH biosynthesis pathway. In higher eukaryotes, this enzyme is… Expand
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Highly Cited
1999
Highly Cited
1999
To investigate rate-limiting factors for glutathione and phytochelatin (PC) production and the importance of these compounds for… Expand
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Highly Cited
1999
Highly Cited
1999
We examined the effects of oxidative stress on rat cultured mesencephalic neurons and glial cells. Glial cells were more… Expand
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Highly Cited
1998
Highly Cited
1998
L-S,R-buthionine sulfoximine (L-S,R BSO) is a potent specific inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting… Expand
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Highly Cited
1997
Highly Cited
1997
The mrp (multidrug resistance protein) gene has been associated with the multidrug resistance of cancer cells in vitro and in… Expand
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Highly Cited
1994
Highly Cited
1994
Many solid tumors contain substantial fractions of hypoxic cells which are relatively resistant to both radiation therapy and… Expand
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Highly Cited
1989
Highly Cited
1989
The metabolism of glutathione and activities of its related enzymes were studied in erythrocytes from patients with non-insulin… Expand
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