GCLC protein, human

Known as: EC 6.3.2.2, Glutamate-Cysteine Ligase Catalytic Subunit, Gamma-Glutamylcysteine Synthetase Catalytic Subunit 
Glutamate-cysteine ligase catalytic subunit (637 aa, ~73 kDa) is encoded by the human GCLC gene. This protein is involved in the biosynthesis of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1983-2017
020406019832017

Papers overview

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2011
2011
Butein and phloretin are chalcones that are members of the flavonoid family of polyphenols. Flavonoids have well-known… (More)
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2008
2008
The ketogenic diet (KD) is a high-fat, low carbohydrate diet that is used as a therapy for intractable epilepsy. However, the… (More)
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2008
2008
Oxidative stress is one of the main causes of vascular disease. This study aims to investigate the antioxidant activity exerted… (More)
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2006
2006
Induction of CYP2E1 by ethanol is one pathway through which ethanol generates oxidative stress. Nrf2 is a transcription factor… (More)
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Highly Cited
2005
Highly Cited
2005
Glutamate cysteine ligase (GCL), which synthesizes gamma-glutamyl-cysteine (gamma-GC), is the rate-limiting enzyme in GSH… (More)
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Highly Cited
2004
Highly Cited
2004
Cruciferous vegetables contain glucosinolates that, after conversion to isothiocyanates (ITC), are capable of inducing… (More)
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Highly Cited
2004
Highly Cited
2004
Glutathione (GSH) significantly declines in the aging rat liver. Because GSH levels are partly a reflection of its synthetic… (More)
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2003
2003
OBJECTIVES The purpose of this study was to test the hypothesis that polymorphisms in the promoter region of the glutamate… (More)
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Highly Cited
2002
Highly Cited
2002
Glutamate-cysteine ligase (GCL) is the rate-limiting enzyme in the GSH biosynthesis pathway. In higher eukaryotes, this enzyme is… (More)
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Highly Cited
2000
Highly Cited
2000
The biosynthesis of reduced glutathione (GSH) is carried out by the enzymes gamma-glutamylcysteine synthetase (GCL) and GSH… (More)
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