Skip to search formSkip to main contentSkip to account menu

GCLC protein, human

Known as: EC 6.3.2.2, Glutamate-Cysteine Ligase Catalytic Subunit, Gamma-Glutamylcysteine Synthetase Catalytic Subunit 
Glutamate-cysteine ligase catalytic subunit (637 aa, ~73 kDa) is encoded by the human GCLC gene. This protein is involved in the biosynthesis of… 
National Institutes of Health

Related topics

Related topics

12 relations
Cytoplasmic matrixEnzyme GeneGCLC geneGCLC wt Allele

Broader (1)

Glutamate-Cysteine Ligase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Upregulation of Oxidative Stress Related Genes in a Chronic Kidney Disease Attributed to Specific Geographical Locations of Sri Lanka
Objective. To infer the influence of internal and external oxidative stress in chronic kidney disease patients of unknown… 
2008
2008
Hyperthermic stress-induced increase in the expression of glutamate-cysteine ligase and glutathione levels in the symbiotic sea anemone Aiptasia pallida.
2005
2005
Human glutamylcysteine synthetase protects HEK293 cells against UV‐induced cell death through inhibition of c‐Jun NH2‐terminal kinase
2005
2005
Nrf 1 and Nrf 2 Regulate Rat Glutamate-Cysteine Ligase Catalytic Subunit Transcription Indirectly via NF-B and AP-1
2000
2000
Dominant-negative Jun N-terminal protein kinase (JNK-1) inhibits metabolic oxidative stress during glucose deprivation in a human breast carcinoma cell line.
Highly Cited
2000
Highly Cited
2000
Inhibition of the 26S proteasome induces expression of GLCLC, the catalytic subunit for gamma-glutamylcysteine synthetase.
The majority of short- and long-lived cellular proteins are degraded by the activities of the 26S proteasome, a large multi… 
Highly Cited
1998
Highly Cited
1998
Expression of Bcl-2 increases intracellular glutathione by inhibiting methionine-dependent GSH efflux.
Overexpression of Bcl-2 and related anti-apoptotic gene products has been shown to increase the intracellular concentration of… 
1998
1998
Structure and refinement of the physical mapping of the γ-glutamylcysteine ligase regulatory subunit (GLCLR) gene to chromosome 1p22.1 within the critically deleted region of human malignant…
Abstract. Glutathione is a ubiquitous antioxidant in mammalian tissues. The first step of its synthesis is catalyzed by the… 
Review
1994
Review
1994
Neurotrophin regulation of energy homeostasis in the central nervous system.
Our hypothesis is that one cause of neuronal cell death and shrinkage in the aged central nervous system is an inability of… 
1988
1988
Mechanisms of synergistic toxicity of the radioprotective agent, WR2721, and 6-hydroxydopamine.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)