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GCLC gene

Known as: GLCLC, glutamate-cysteine ligase catalytic subunit, GLUTAMATE-CYSTEINE LIGASE, CATALYTIC SUBUNIT 
This gene plays a role in the detoxification of endogenous reactive oxygen species. It is also involved in drug and xenobiotic metabolism.
National Institutes of Health

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Anemia, HemolyticGCLC protein, humanMetabolic Detoxication, DrugMyocardial Infarction

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GCLC wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Genetic susceptibility analysis of GCLC rs17883901 polymorphism to preeclampsia in Chinese Han women
Abstract Preeclampsia (PE) is a specific obstetric disorder that may result in maternal and neonatal morbidity and mortality… 
2015
2015
Over expression of Nrf 2 in Umbilical Cord-derived Mesenchymal Stem Cells Up regulates Cytoprotective Genes , TXNRD 1 and GCLC
Background: Mesenchymal stem cells (MSCs) are ideal cells for cell and gene therapy. However, the low survival of MSCs after… 
2008
2008
No effects of EPHX1 polymorphisms on the level or change of FEV1 in the general population
To the Editors: Chappell et al. 1 recently found that several single nucleotide polymorphisms (SNPs) in the glutamate cysteine… 
2007
2007
[The glutamate-cysteine ligase catalytic subunit gene C-129T and modifier subunit gene G-23T polymorphisms and risk for coronary diseases].
OBJECTIVE To investigate the possible association between the glutamate-cysteine ligase catalytic subunit gene (GCLC) C-129T and… 
2006
2006
cDNA cloning and expression analysis of the catalytic subunit of glutamate cysteine ligase gene in an annelid polychaete after cadmium exposure: a potential tool for pollution biomonitoring.
2005
2005
Identification of an E-box motif as a transcriptional repressor element in the proximal promoter region of the GCLC gene in rat lung epithelial L2 cells.
2002
2002
Identification and mutational analysis of candidate genes for juvenile myoclonic epilepsy on 6p11–p12: LRRC1, GCLC, KIAA0057 and CLIC5
2001
2001
Localization of glutamate-cysteine ligase mRNA and protein in mouse kidney and induction with methylmercury.
Highly Cited
1997
Highly Cited
1997
Alteration of transcriptional and post-transcriptional expression of gamma-glutamylcysteine synthetase by diethyl maleate.
Gamma-glutamylcysteine synthetase (gamma-GCS), also known as glutamate-cysteine ligase (EC 6.3.2.2), is the rate-limiting enzyme… 
Highly Cited
1983
Highly Cited
1983
Germinal center B cells lack homing receptors necessary for normal lymphocyte recirculation
Germinal center B cells (GCLC) are a discrete population of antigen- activated lymphoblasts that lack surface IgD and express… 
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