GCLC gene

Known as: GLCLC, glutamate-cysteine ligase catalytic subunit, GLUTAMATE-CYSTEINE LIGASE, CATALYTIC SUBUNIT 
This gene plays a role in the detoxification of endogenous reactive oxygen species. It is also involved in drug and xenobiotic metabolism.
National Institutes of Health

Papers overview

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2017
2017
Here, we identified two new molecular targets, which are functionally sufficient to metabolically confer the tamoxifen-resistance… (More)
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2015
2015
Flux balance analysis is the only modelling approach that is capable of producing genome-wide predictions of gene essentiality… (More)
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2013
2013
SCOPE Flavonoids have well-known antioxidant, anti-inflammatory, and anti-cancer activities. Isoflavone genistein is considered a… (More)
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2013
2013
This study was conducted to establish the possible contribution of functional gene polymorphisms in detoxification/oxidative… (More)
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2012
2012
Sulfamethoxazole (SMX) is a commonly used antibiotic for prevention of infectious diseases associated with HIV/AIDS and immune… (More)
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2011
2011
A guanine-adenine-guanine (GAG) repeat polymorphism with 5 different alleles (4, 7, 8, 9, and 10 repeats) in the 5' untranslated… (More)
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2008
2008
RATIONALE Smoking-induced oxidative stress contributes to chronic obstructive pulmonary disease, a lung disease characterized by… (More)
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Highly Cited
2006
Highly Cited
2006
The Nrf2 (nuclear factor-erythroid 2 p45-related factor 2) transcription factor regulates gene expression of the GCLC (glutamate… (More)
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2005
2005
This study provides evidence that in mammary epithelial cells the pluripotent cytokine TGF-beta1 repressed expression of multiple… (More)
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Highly Cited
2000
Highly Cited
2000
The biosynthesis of reduced glutathione (GSH) is carried out by the enzymes gamma-glutamylcysteine synthetase (GCL) and GSH… (More)
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