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GCLC wt Allele

Known as: GLCLC, GCL, GLCL 
Human GCLC wild-type allele is located within 6p12 and is approximately 48 kb in length. This allele, which encodes glutamate-cysteine ligase… 
National Institutes of Health

Related topics

Related topics

8 relations
6p12Anemia, HemolyticGCLC protein, humanMetabolic Detoxication, Drug

Broader (1)

GCLC gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Glutathione regulation in arsenic-induced porcine aortic endothelial cells.
2008
2008
Regulation of GCL activity and cellular glutathione through inhibition of ERK phosphorylation
Extracellular signal‐regulated protein kinase (ERK), one of the mitogen‐activated protein kinase, has been known to be involved… 
2001
2001
Localization of glutamate-cysteine ligase mRNA and protein in mouse kidney and induction with methylmercury.
2000
2000
Regulation of gamma-glutamate-cysteine ligase expression by oxidative stress in the mouse preimplantation embryo.
The present study examined expression of gamma-glutamate-cysteine ligase (GLCL; also known as gamma-glutamylcysteine synthetase… 
2000
2000
Structure of the human glutamate-L-cysteine ligase catalytic (GLCLC) subunit gene
Glutamate-L-cysteine ligase (GLCL [EC 6.3.2.2], also referred to as γ-glutamylcysteine synthetase) catalyzes the rate-limiting… 
Highly Cited
1999
Highly Cited
1999
Effect of dietary inducer dimethylfumarate on glutathione in cultured human retinal pigment epithelial cells.
PURPOSE To determine the effect of dimethylfumarate (DMF), an inducer of glutathione (GSH)-dependent detoxification, on… 
Highly Cited
1999
Highly Cited
1999
Induction of glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) in the brains of adult female mice subchronically exposed to methylmercury.
Highly Cited
1997
Highly Cited
1997
Alteration of transcriptional and post-transcriptional expression of gamma-glutamylcysteine synthetase by diethyl maleate.
Gamma-glutamylcysteine synthetase (gamma-GCS), also known as glutamate-cysteine ligase (EC 6.3.2.2), is the rate-limiting enzyme… 
1997
1997
Molecular cloning and sequencing of the cDNA encoding the catalytic subunit of mouse glutamate-cysteine ligase.
1982
1982
Inhibition by nojirimycin and 1-deoxynojirimycin of microsomal glucosidases from calf liver acting on the glycoprotein oligosaccharides Glc1–3Man9GlcNAc2
Particulate membrane fractions from calf liver catalyze the release of glucose from GlcNAc2-Man9-Glc1–3-oligosaccharides. Maximal… 
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