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Superoxide dismutases in the lung and human lung diseases.
  • V. Kinnula, J. Crapo
  • Medicine
  • American journal of respiratory and critical care…
  • 15 June 2003
The lungs are directly exposed to higher oxygen concentrations than most other tissues. Increased oxidative stress is a significant part of the pathogenesis of obstructive lung diseases such asExpand
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SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.
RATIONALE Abnormal inflammation and accelerated decline in lung function occur in patients with chronic obstructive pulmonary disease (COPD). Human sirtuin (SIRT1), an antiaging and antiinflammatoryExpand
  • 409
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Superoxide dismutases in malignant cells and human tumors.
Reactive oxygen metabolites have multifactorial effects on the regulation of cell growth and the capacity of malignant cells to invade. Overexpression of the superoxide dismutases (SODs) in vitroExpand
  • 326
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Oxidative stress in pulmonary fibrosis: a possible role for redox modulatory therapy.
Idiopathic ulmonary fibrosis (histopathology of usual interstitial pneumonia) is a progressive lung disease of unknown etiology. No treatment has been shown to improve the prognosis of the patientsExpand
  • 317
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SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
Chronic obstructive pulmonary disease/emphysema (COPD/emphysema) is characterized by chronic inflammation and premature lung aging. Anti-aging sirtuin 1 (SIRT1), a Expand
  • 257
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Generation and disposal of reactive oxygen metabolites in the lung.
  • 217
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Peroxiredoxins in breast carcinoma.
PURPOSE Peroxiredoxins (Prxs) are a novel group of peroxidases containing high antioxidant efficiency and some of them having also effects on cell differentiation and apoptosis. The mammalian PrxExpand
  • 214
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Transforming growth factor-beta activation in the lung: focus on fibrosis and reactive oxygen species.
Transforming growth factor-betas (TGF-beta) regulate a wide variety of cellular functions in normal development and are involved in both tissue homeostasis and disease pathogenesis. The regulation ofExpand
  • 143
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Differences in plasma and sputum biomarkers between COPD and COPD–asthma overlap
The pathophysiological features of chronic obstructive pulmonary disease (COPD)–asthma overlap are poorly understood and there has been no study of plasma or sputum biomarkers in overlap patients. InExpand
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Overlap Syndrome of Asthma and COPD Predicts Low Quality of Life
Background. In clinical practice, patients whose airway disease shares features of both asthma and chronic obstructive pulmonary disease (COPD) remain poorly recognized. Material and methods. TheExpand
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