Stem cells, cancer, and cancer stem cells
- T. Reya, S. Morrison, M. Clarke, I. Weissman
- Biology, MedicineNature
- 1 November 2001
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor…
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
- K. Akashi, D. Traver, T. Miyamoto, I. Weissman
- BiologyNature
- 9 March 2000
The prospective identification, purification and characterization, using cell-surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloids lineages is reported.
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
- M. Prince, R. Sivanandan, L. Ailles
- Biology, MedicineProceedings of the National Academy of Sciences
- 16 January 2007
Data demonstrate that cells within the CD44+ population of human HNSCC possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation and form unique histological microdomains that may aid in cancer diagnosis.
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
- M. Kondo, I. Weissman, K. Akashi
- Biology, MedicineCell
- 28 November 1997
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression. The meeting participants were charged with evaluating data suggesting…
Wnt proteins are lipid-modified and can act as stem cell growth factors
- K. Willert, Jeffrey Brown, R. Nusse
- BiologyNature
- 22 May 2003
This work isolated active Wnt molecules, including the product of the mouse Wnt3a gene, and found the proteins to be palmitoylated on a conserved cysteine, indicating that the lipid is important for signalling.
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
- In-kyung Park, D. Qian, M. Clarke
- Biology, MedicineNature
- 15 May 2003
The results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs, which are required for haematopoiesis to persist for the lifetime of the animal.
A role for Wnt signalling in self-renewal of haematopoietic stem cells
- T. Reya, A. Duncan, I. Weissman
- BiologyNature
- 22 May 2003
It is concluded that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and insight is provided into a potential molecular hierarchy of regulation of HSC development.
New tools for studying microglia in the mouse and human CNS
- Mariko L. Bennett, F. C. Bennett, B. Barres
- BiologyProceedings of the National Academy of Sciences
- 16 February 2016
Transmembrane protein 119 (Tmem119), a cell-surface protein of unknown function, is identified as a highly expressed microglia-specific marker in both mouse and human, which will greatly facilitate understanding of microglial function in health and disease.
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
- I. Conboy, M. Conboy, A. Wagers, Eric R. Girma, I. Weissman, T. Rando
- Biology, MedicineNature
- 17 February 2005
Heterochronic parabiosis increased aged hepatocyte proliferation and restored the cEBP-α complex to levels seen in young animals, suggesting that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age.
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