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Stem cells, cancer, and cancer stem cells
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitorExpand
A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
The prospective identification, purification and characterization, using cell-surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloids lineages is reported. Expand
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma
Data demonstrate that cells within the CD44+ population of human HNSCC possess the unique properties of cancer stem cells in functional assays for cancer stem cell self-renewal and differentiation and form unique histological microdomains that may aid in cancer diagnosis. Expand
Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells.
A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell model for tumor development and progression. The meeting participants were charged with evaluating data suggestingExpand
Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
The Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) population from adult mouse bone marrow possessed a rapid lymphoid-restricted (T, B, and NK) reconstitution capacity in vivo but completely lacked myeloid differentiation potential either in vivo or in vitro. Expand
Wnt proteins are lipid-modified and can act as stem cell growth factors
This work isolated active Wnt molecules, including the product of the mouse Wnt3a gene, and found the proteins to be palmitoylated on a conserved cysteine, indicating that the lipid is important for signalling. Expand
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
The results indicate that Bmi-1 is essential for the generation of self-renewing adult HSCs, which are required for haematopoiesis to persist for the lifetime of the animal. Expand
Direct isolation of human central nervous system stem cells.
Upon transplantation into brains of immunodeficient neonatal mice, the sorted/expanded hCNS-SC showed potent engraftment, proliferation, migration, and neural differentiation. Expand
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
Heterochronic parabiosis increased aged hepatocyte proliferation and restored the cEBP-α complex to levels seen in young animals, suggesting that the age-related decline of progenitor cell activity can be modulated by systemic factors that change with age. Expand
A role for Wnt signalling in self-renewal of haematopoietic stem cells
It is concluded that the Wnt signalling pathway is critical for normal HSC homeostasis in vitro and in vivo, and insight is provided into a potential molecular hierarchy of regulation of HSC development. Expand