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Lymphocyte Homing and Homeostasis
A review of the molecular basis of lymphocyte homing is presented, and mechanisms by which homing physiology regulates the homeostasis of immunologic resources are proposed. Expand
Chemerin, a Novel Adipokine That Regulates Adipogenesis and Adipocyte Metabolism*
It is concluded that chemerin is a novel adipose-derived signaling molecule that regulates adipogenesis and adipocyte metabolism and has a role in adaptive and innate immunity. Expand
A cell-surface molecule involved in organ-specific homing of lymphocytes
A monoclonal antibody specific for a lymphocyte surface molecule that appears to mediate recognition of lymph node HEV and to be required for lymphocyte homing into lymph nodes in vivo is described. Expand
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
The results suggest that CCR4 and TARC are important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to their target tissues. Expand
Lymphocyte trafficking and regional immunity.
The chapter discusses the present understanding of tissue-selective lymphocyte trafficking, focusing in particular on the gut and its associated lymphoid tissues, with emphasis on the importance of these mechanisms for the understanding and manipulation of regional immune responses in the gastrointestinal tract. Expand
Subspecialization of Cxcr5+ T Cells: B Helper Activity Is Focused in a Germinal Center–Localized Subset of Cxcr5+ T Cells
It is demonstrated that CX CR5+ T cells are functionally heterogeneous and that the GC-Th cells, a small subset of CXCR5- T cells, are the key helpers for B cell differentiation and antibody production in lymphoid tissues. Expand
Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire1
  • James J. Campbell, Shixin Qin, +5 authors E. Butcher
  • Biology, Medicine
  • The Journal of Immunology
  • 1 June 2001
A diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types are described. Expand
Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flow.
It is shown that the chemokines SLC, ELC, and SDF-1alpha rapidly induce lateral mobility and transient increase of affinity of the beta2 integrin LFA-1 that can coordinately determine the vascular arrest of circulating lymphocytes under physiologic conditions. Expand
Mast cell–expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis
It is shown that the mast cell–expressed orphan serpentine receptor mCCRL2 is not required for expression of IgE-mediated mast cell-dependent passive cutaneous anaphylaxis but can enhance the tissue swelling and leukocyte infiltrates associated with such reactions in mice. Expand