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Chronic obstructive pulmonary disease.
TLDR
This data indicates that COPD ranks third among the most common causes of death in males and fourth in women in New Zealand and has been estimated to cost the New Zealand community an estimated $102–$192 million annually.
Genetic studies of body mass index yield new insights for obesity biology
TLDR
A genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals provide strong support for a role of the central nervous system in obesity susceptibility.
Development, validity and responsiveness of the Clinical COPD Questionnaire
TLDR
The CCQ is a self-administered questionnaire specially developed to measure clinical control in patients with COPD and thirty-six smokers with and without COPD showed significant improvement in the CCQ after 2 months smoking cessation, indicating the responsiveness of theCCQ.
An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease.
TLDR
It is concluded that specific genetic syndromes and occupational exposures were causally related to the development of COPD and a substantive burden of COPd is attributable to risk factors other than smoking.
Optimal assessment and management of chronic obstructive pulmonary disease (COPD). The European Respiratory Society Task Force.
TLDR
The guidelines are intended for use by physicians involved in the care of patients with COPD, and their main goals are to inform health professionals and to reverse a widespread nihilistic approach to the management of these patients.
Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group.
TLDR
In patients who have persistent symptoms of asthma despite treatment with inhaled glucocorticoids, the addition of formoterol to budesonid therapy or the use of a higher dose of budesonide may be beneficial.
The Asthma-COPD Overlap Syndrome.
TLDR
The asthma-COPD overlap syndrome is reviewed, showing an increasing awareness that many patients have features of both disorders.
Protein tyrosine nitration: selectivity, physicochemical and biological consequences, denitration, and proteomics methods for the identification of tyrosine-nitrated proteins.
TLDR
The main nitration reactions and elucidate why nitration is not a random chemical process are reviewed and the possibility of an in vivo denitration process is indicated.
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
TLDR
A genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly with myocardial infarction in six different populations.
Air pollution and development of asthma, allergy and infections in a birth cohort
TLDR
Air pollution was associated with respiratory infections and some measures of asthma and allergy during the first 4 yrs of life and positive associations between air pollution and specific sensitisation to common food allergens were found.
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