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We sought to elucidate the role of AKT in follicle-stimulating hormone (FSH)-mediated granulosa cell (GC) differentiation. Our… Expand Mutations of the ras gene are among the most commonly identified transforming events in human cancers, including multiple myeloma… Expand Lovastatin is an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the major regulatory enzyme… Expand Bisphosphonates are the important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Although their… Expand ABSTRACT Farnesyltransferase inhibitors (FTIs) represent a novel class of anticancer drugs that exhibit a remarkable ability to… Expand The inhibitors of protein prenylation have been proposed for chemotherapy of tumors. Lovastatin, a 3-hydroxy-3-methylglutaryl… Expand The mechanism by which the geranylgeranyltransferase I inhibitor GGTI-298 and the farnesyltransferase inhibitor FTI-277 inhibit… Expand The farnesyltransferase (FTase) inhibitor FTI-277 is highly effective at blocking oncogenic H-Ras but not K-Ras4B processing and… Expand Many tumor cells have a greater resistance to ionizing radiation than their normal counterparts, suggesting that the development… Expand Ras-induced malignant transformation requires Ras farnesylation, a lipid posttranslational modification catalyzed by… Expand