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FTI 277

Known as: FTI-277 
National Institutes of Health

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4 relations

Broader (3)

Enzyme InhibitorsMethionineRadiation-Sensitizing Agents
analogs & derivatives

Papers overview

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2018
2018
Prenylation inhibitors stimulate both estrogen receptor alpha transcriptional activity through AF-1 and AF-2 and estrogen receptor beta transcriptional activity.
Introduction We showed in a previous study that prenylated proteins play a role in estradiol stimulation of proliferation… 
2018
2018
Mechanical Signaling in NF1 Osteoblast Cell
Neurofibromatosis Type I (NF1) syndrome is characterized by neurofibromas and neural tumors but is also associated with skeletal… 
2017
2017
Farnesyltransferase inhibitor FTI‐277 inhibits PD‐L1 expression on septic spleen lymphocytes and promotes spleen lymphocyte activation
Farnesyltransferase inhibitors have been tested in clinical trials for the treatment of tumours. In sepsis, the binding of… 
2014
2014
Farnesyltransferase Regulates Neutrophil Recruitment and Tissue Damage in Acute Pancreatitis
Objectives The signaling mechanisms controlling organ damage in the pancreas in severe acute pancreatitis (AP) remain elusive… 
2012
2012
the Lungs Macrophages and Neutrophil Infiltration of of CXC Chemokines in Alveolar Farnesyltransferase-Dependent Formation Streptococcal M 1 Protein Triggers
2011
2011
3 FTI-277 inhibits vascular calcification by activating downstream Pi3k/Akt signalling and preventing apoptosis of vascular smooth muscle cells
Vascular calcification, which involves the osteogenic differentiation of vascular smooth muscle cells (VSMC), is a major… 
2007
2007
mTOR Inhibitor Rapamycin Interacts Synergistically with Farnesyltransferase Inhibitor FTI-277 To Induce Growth Inhibition in Human Leukemia Cells.
Proteins regulating the mammalian target of rapamycin (mTOR), as well as some of the targets of the mTOR kinase, are… 
2006
2006
Antiproliferative effects of FTI-277 on chronic myeloid leukemia cells and inhibition of the ERK/MAPK signal pathway
Objective To investigate the expression of extracellular signal-regulated kinase(ERK)/mitogen-activated protein kinase(MAPK) in… 
2003
2003
Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines.
Farnesyltransferase inhibitors (FTIs) block the growth of tumor cells in vitro and in vivo with minimal toxicity toward normal… 
2003
2003
Farnesyltransferase inhibitor FTI-277 prevents autocrine growth stimulation of neuroblastoma by BDNF
PurposeAutocrine growth stimulation by IGF-II and BDNF is frequently observed in neuroblastoma. The signals of the receptors of… 
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