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FTI 277

Known as: FTI-277 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Enzyme InhibitorsMethionineRadiation-Sensitizing Agents
analogs & derivatives

Papers overview

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2008
2008
Drugs affecting prelamin A processing: effects on heterochromatin organization.
2008
2008
Lovastatin inhibits oxidized low-density lipoprotein-induced plasminogen activator inhibitor and transforming growth factor-beta1 expression via a decrease in Ras/extracellular signal-regulated…
2008
2008
Mevalonate sensitizes the nociceptive transmission in the mouse spinal cord
Highly Cited
2006
Highly Cited
2006
Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.
Rho family GTPases are frequently overexpressed in breast cancers, which regulate cancer cell migration and invasion. They… 
Highly Cited
2003
Highly Cited
2003
Additive effects of tamoxifen and the farnesyl transferase inhibitor FTI‐277 on inhibition of MCF‐7 breast cancer cell‐cycle progression
The efficacy of tamoxifen in the hormonal therapy of breast cancer is well established, but therapeutic resistance is inevitable… 
2003
2003
Growth inhibition by the farnesyltransferase inhibitor FTI-277 involves Bcl-2 expression and defective association with Raf-1 in liver cancer cell lines.
Farnesyltransferase inhibitors (FTIs) block the growth of tumor cells in vitro and in vivo with minimal toxicity toward normal… 
2003
2003
Farnesyltransferase inhibitor FTI-277 prevents autocrine growth stimulation of neuroblastoma by BDNF
PurposeAutocrine growth stimulation by IGF-II and BDNF is frequently observed in neuroblastoma. The signals of the receptors of… 
1999
1999
Characterization of the Ras homologue of Schistosoma mansoni.
1999
1999
Prenyltransferase Inhibitors Induce Apoptosis in Proliferating Thyroid Cells through a p53-Independent, CrmA-Sensitive, and Caspase-3-Like Protease- Dependent Mechanism.
The inhibitors of protein prenylation have been proposed for chemotherapy of tumors. Lovastatin, a 3-hydroxy-3-methylglutaryl… 
1999
1999
Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism.
The inhibitors of protein prenylation have been proposed for chemotherapy of tumors. Lovastatin, a 3-hydroxy-3-methylglutaryl… 
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