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FTI 277

Known as: FTI-277 
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
We sought to elucidate the role of AKT in follicle-stimulating hormone (FSH)-mediated granulosa cell (GC) differentiation. Our… Expand
Highly Cited
2003
Highly Cited
2003
Mutations of the ras gene are among the most commonly identified transforming events in human cancers, including multiple myeloma… Expand
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Highly Cited
2001
Highly Cited
2001
Lovastatin is an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the major regulatory enzyme… Expand
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Highly Cited
2000
Highly Cited
2000
Bisphosphonates are the important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Although their… Expand
Highly Cited
2000
Highly Cited
2000
  • Kun Jiang, D. Coppola, +4 authors Jin Q. Cheng
  • Molecular and Cellular Biology
  • 2000
  • Corpus ID: 41779852
ABSTRACT Farnesyltransferase inhibitors (FTIs) represent a novel class of anticancer drugs that exhibit a remarkable ability to… Expand
1999
1999
The inhibitors of protein prenylation have been proposed for chemotherapy of tumors. Lovastatin, a 3-hydroxy-3-methylglutaryl… Expand
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Highly Cited
1997
Highly Cited
1997
The mechanism by which the geranylgeranyltransferase I inhibitor GGTI-298 and the farnesyltransferase inhibitor FTI-277 inhibit… Expand
Highly Cited
1997
Highly Cited
1997
The farnesyltransferase (FTase) inhibitor FTI-277 is highly effective at blocking oncogenic H-Ras but not K-Ras4B processing and… Expand
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Highly Cited
1996
Highly Cited
1996
Many tumor cells have a greater resistance to ionizing radiation than their normal counterparts, suggesting that the development… Expand
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Highly Cited
1995
Highly Cited
1995
  • E. Lerner, Yimin Qian, +7 authors S. Sebti
  • The Journal of Biological Chemistry
  • 1995
  • Corpus ID: 23662027
Ras-induced malignant transformation requires Ras farnesylation, a lipid posttranslational modification catalyzed by… Expand
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