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FTI 277

Known as: FTI-277 
 
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
We sought to elucidate the role of AKT in follicle-stimulating hormone (FSH)-mediated granulosa cell (GC) differentiation. Our… Expand
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2003
2003
The efficacy of tamoxifen in the hormonal therapy of breast cancer is well established, but therapeutic resistance is inevitable… Expand
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Highly Cited
2002
Highly Cited
2002
Geranylgeranylation of RhoA small G-protein is essential for its localization to cell membranes and for its biological functions… Expand
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Highly Cited
2001
Highly Cited
2001
Lovastatin is an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the major regulatory enzyme… Expand
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Highly Cited
2000
Highly Cited
2000
Bisphosphonates are the important class of antiresorptive drugs used in the treatment of metabolic bone diseases. Although their… Expand
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Highly Cited
2000
Highly Cited
2000
Farnesyltransferase inhibitors (FTIs) represent a novel class of anticancer drugs that exhibit a remarkable ability to inhibit… Expand
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Highly Cited
1997
Highly Cited
1997
The mechanism by which the geranylgeranyltransferase I inhibitor GGTI-298 and the farnesyltransferase inhibitor FTI-277 inhibit… Expand
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Highly Cited
1997
Highly Cited
1997
The farnesyltransferase (FTase) inhibitor FTI-277 is highly effective at blocking oncogenic H-Ras but not K-Ras4B processing and… Expand
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Highly Cited
1996
Highly Cited
1996
Many tumor cells have a greater resistance to ionizing radiation than their normal counterparts, suggesting that the development… Expand
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Highly Cited
1995
Highly Cited
1995
Ras-induced malignant transformation requires Ras farnesylation, a lipid posttranslational modification catalyzed by… Expand
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