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Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesizes bacteriophage T7 RNA polymerase.
DNA coding for bacteriophage T7 RNA polymerase was ligated to a vaccinia virus transcriptional promoter and integrated within the vaccinia virus genome. The recombinant vaccinia virus retainedExpand
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Thyroid hormone receptor orthologues from invertebrate species with emphasis on Schistosoma mansoni
Background:Thyroid hormone receptors (TRs) function as molecular switches in response to thyroid hormone to regulate gene transcription. TRs were previously believed to be present only inExpand
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A poxvirus-encoded uracil DNA glycosylase is essential for virus viability.
Infection of cultured mammalian cells with the Leporipoxvirus Shope fibroma virus (SFV) causes the induction of a novel uracil DNA glycosylase activity in the cytoplasms of the infected cells. TheExpand
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Domain Structure of the Vaccinia Virus mRNA Capping Enzyme
The RNA 5′-triphosphatase, nucleoside triphosphate phosphohydrolase, and guanylyltransferase activities of the vaccinia virus mRNA capping enzyme were previously localized to an NH-terminal 60-kDaExpand
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The mRNA (guanine-7-)methyltransferase domain of the vaccinia virus mRNA capping enzyme. Expression in Escherichia coli and structural and kinetic comparison to the intact capping enzyme.
The mRNA (guanine-7-)methyltransferase active site of the heterodimeric vaccinia virus mRNA capping enzyme was previously localized to the carboxyl-terminal third of the large subunit, D1R,Expand
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Evolution of a novel subfamily of nuclear receptors with members that each contain two DNA binding domains
BackgroundNuclear receptors (NRs) are important transcriptional modulators in metazoans which regulate transcription through binding to the promoter region of their target gene by the DNA bindingExpand
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Schistosoma mansoni male-female interactions
Schistosome parasites are muticellular eucaryotic organisms with a complex life cycle that involves mammalian and snail hosts. Unlike other trematode parasites, schistosomes (along with the Didymoz...
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Vaccinia virus gene D8 encodes a virion transmembrane protein.
Transcription mapping studies and DNA sequence analysis of the vaccinia virus HindIII D fragment predict that gene D8 encodes a protein 304 amino acids in length, with a molecular mass of 35,426Expand
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Nucleotide sequence and genetic map of the 16-kb vaccinia virus HindIII D fragment.
We have determined the nucleotide sequence of the 16,059-bp HindIII D fragment from vaccinia virus strain WR. Translation in all 6 reading frames reveals a set of 22 open reading frames (ORFs), whichExpand
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E2/E3-mediated Assembly of Lysine 29-linked Polyubiquitin Chains*
Polyubiquitin (Ub) chains linked through Lys-48–Gly-76 isopeptide bonds represent the principal signal by which substrates of the Ub-dependent protein degradation pathway are targeted to the 26 SExpand
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