Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.

@article{Kusama2006InhibitionOT,
  title={Inhibition of transendothelial migration and invasion of human breast cancer cells by preventing geranylgeranylation of Rho.},
  author={Toshiyuki Kusama and Mutsuko Mukai and Masaharu Tatsuta and Hiroyuki Nakamura and Masahiro Inoue},
  journal={International journal of oncology},
  year={2006},
  volume={29 1},
  pages={217-23}
}
Rho family GTPases are frequently overexpressed in breast cancers, which regulate cancer cell migration and invasion. They require prenylation, a lipid post-translational modification, for full biological functions. We examined the effects of 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (fluvastatin), a selective farnesyltransferase inhibitor (FTI-277) and a selective geranylgeranyltransferase type I inhibitor (GGTI-298) on in vitro invasive capacity of MDA-MB-231 human… CONTINUE READING

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