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FCGR3A protein, human

Known as: Fc-Gamma RIII, FcgammaRIIIA, Fc-Gamma RIIIA 
Low affinity immunoglobulin gamma Fc region receptor III-A (254 aa, ~29 kDa) is encoded by the human FCGR3A gene. This protein is involved in… 
National Institutes of Health

Related topics

Related topics

18 relations
Antibody-Dependent Cellular CytotoxicityFCGR3A geneFCGR3A wt AlleleFCGR3B gene

Broader (2)

Antigens, CD16Receptors, IgG

Papers overview

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Review
2011
Review
2011
Pharmacogenetic tests in cancer chemotherapy: what physicians should know for clinical application
Significant efforts to develop pharmacogenomic predictors have been made to guide more effective and safer chemotherapy. Although… 
Highly Cited
2007
Highly Cited
2007
Association between SLE nephritis and polymorphic variants of the CRP and FcgammaRIIIa genes.
OBJECTIVES To study the relationship between clinical manifestations in systemic lupus erythematosus (SLE) with polymorphisms in… 
Highly Cited
2007
Highly Cited
2007
Functional role of phosphatidylcholine‐specific phospholipase C in regulating CD16 membrane expression in natural killer cells
CD16, the low‐affinity FcIgG receptor (FcγRIIIA), is predominantly expressed in human NK cells. Our recent findings indicate that… 
2006
2006
Fucose removal from complex-type oligosaccharide enhances the antibody-dependent cellular cytotoxicity of single-gene-encoded bispecific antibody comprising of two single-chain antibodies linked to…
Bispecific antibodies (bsAbs) have the potential to extend binding selectivity, increase avidity and exert potent cytotoxicity… 
2005
2005
Arf6: a new player in FcgammaRIIIA lymphocyte-mediated cytotoxicity.
The activation of phosphoinositide metabolism represents a critical step in the signaling pathways leading to the activation of… 
Highly Cited
2003
Highly Cited
2003
Rapid single-step FCGR3A genotyping based on SYBR Green I fluorescence in real-time multiplex allele-specific PCR.
2002
2002
FcgammaRIIA, FcgammaRIIIA and FcgammaRIIIB polymorphisms in Spanish patients with systemic lupus erythematosus.
Linkage studies on human families suggest that receptors for the Fc fragments of immunoglobulin G (IgG) (FcgammaRs) could be… 
2001
2001
FcγRIIa/IIIa polymorphism and its association with clinical manifestations in Korean lupus patients
The aim of this study was to determine the distribution of the FcgRIIa and FcgRIIIa polymorphisms and their association with… 
1992
1992
Differential roles of Fc gamma RII and Fc gamma RIII in immune complex stimulation of human neutrophils.
1990
1990
The Fc-receptor III of cultured human monocytes. Structural similarity with FcRIII of natural killer cells and role in the extracellular lysis of sensitized erythrocytes.
FcRIII is not present on peripheral blood monocytes, but becomes expressed upon culturing and can be demonstrated on tissue… 
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