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FCGR3A gene

Known as: Fc gamma receptor IIIa, CD16, Fc fragment of IgG receptor IIIa 
This gene plays a role in the mediation of antibody-dependent cytotoxicity and phagocytosis.
National Institutes of Health

Related topics

Related topics

13 relations
Antibody-Dependent Cellular CytotoxicityAntigens, CD16FCGR3A protein, humanFCGR3B gene

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FCGR3A wt Allele

Papers overview

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2019
2019
Antitumor activity of margetuximab (M) plus pembrolizumab (P) in patients (pts) with advanced HER2+ (IHC3+) gastric carcinoma (GC).
65 Background: Trastuzumab (T) + chemo is standard first-line therapy (tx) for HER2+ gastroesophageal adenocarcinoma (GEA) pts… 
2017
2017
Abstract 5671: AFM26 - A novel CD16A-directed bispecific TandAb targeting BCMA for multiple myeloma
Multiple myeloma (MM) is the second most common haematological cancer and is characterized by the accumulation of neoplastic… 
2012
2012
Abstract 3522: Preclinical development of an anti-CD30/anti-CD16A bispecific tetravalent TandAb antibody for the treatment of Hodgkin lymphoma
NK cells are professional cytotoxic immune effector cells and, unlike cytotoxic T cells, exist in a constitutively activated… 
2011
2011
Polymorphisms of CD16A and CD32 Fcγ receptors and circulating immune complexes in Ménière's disease: a case-control study
BackgroundAutoimmune diseases with elevated circulating autoantibodies drive tissue damage and the onset of disease. The Fc… 
2010
2010
Functional Variants of Fc Gamma Receptor (FCGR2A) and FCGR3A Are Not Associated with Susceptibility to Systemic Sclerosis in a Large European Study (EUSTAR)
Objective. To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic… 
2010
2010
Predictive value of FCGR3A genotype on response to rituximab induction and maintenance therapy (MT) in follicular non-Hodgkin's lymphoma (NHL).
8065 Background: The F158V variant of the Fc gamma 3A receptor (FCGR3A) correlates with clinical response to rituximab. In SAKK… 
2006
2006
A novel single‐nucleotide polymorphism of the Fcγ receptor IIIa gene is associated with genetic susceptibility to systemic lupus erythematosus in Chinese populations: a family‐based association study
Background.  Systemic lupus erytematosus (SLE) is characterized by the presence of various autoantibodies and the deposition of… 
2005
2005
A Common Genetic Variant in FCGR3A-V158F and Risk of Kaposi Sarcoma Herpesvirus Infection and Classic Kaposi Sarcoma
Associations of FCGR3A among men with HIV/acquired immunodeficiency syndrome suggest that host responses affect the pathogenesis… 
2002
2002
Recombinant CD16A-Ig forms a homodimer and cross-blocks the ligand binding functions of neutrophil and monocyte Fcgamma receptors.
Highly Cited
2001
Highly Cited
2001
Polymorphisms in inflammatory cytokines and Fcγ receptors in childhood chronic immune thrombocytopenic purpura: a pilot study
Inflammatory cytokines and low‐affinity Fcγ receptor (FcγR) polymorphisms were investigated in 37 children with chronic immune… 
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