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Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype.
Differences in IgG binding among the three Fc gammaRIIIa-48L/R/H isoforms are a consequence of the linked, biallelic Fc Gamma receptor IIIa-158V/F polymorphism at amino-acid position 158.
Recombinant granulocyte colony-stimulating factor administration to healthy volunteers: induction of immunophenotypically and functionally altered neutrophils via an effect on myeloid progenitor…
It is shown that G-CSF results in an immunophenotypically and functionally altered neutrophil population for an important part as a result of its effect on myeloid precursor cells.
Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro.
- C. Homburg, M. de Haas, A. von dem Borne, A. Verhoeven, C. Reutelingsperger, D. Roos
- 15 January 1995
The results indicate that soluble Fc gamma RIII in body fluids might be derived for a large part from neutrophils undergoing apoptosis in the tissues.
Granulocyte colony-stimulating factor administration to healthy volunteers: analysis of the immediate activating effects on circulating neutrophils.
It is postulate that the most activated neutrophils leave the circulation, as observed shortly postinjection, and undergo subsequent stimulation in the endothelial microenvironment, resulting in mobilization of azurophil granules.
Deficiency of glycosyl-phosphatidylinositol-linked membrane glycoproteins of leukocytes in paroxysmal nocturnal hemoglobinuria, description of a new diagnostic cytofluorometric assay.
- C. E. van der Schoot, T. Huizinga, E. T. van 't Veer-Korthof, R. Wijmans, J. Pinkster, A. von dem Borne
- Biology, MedicineBlood
- 1 November 1990
The introduction of a new diagnostic cytofluorometric assay for PNH with MoAbs against GPI-linked granulocytic antigens is introduced, which indicates that the new test is more sensitive than the Ham test and allows the early diagnosis of PNH in AA.
Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.
- R. Goldschmeding, C. E. van der Schoot, A. von dem Borne
- Biology, MedicineJournal of Clinical Investigation
- 1 November 1989
It is demonstrated that in some perinuclear staining (P-ANCA) patients' sera autoantibodies against other myeloid lysosomal enzymes can be detected, such as antimyeloperoxidase and antielastase.
Pseudothrombocytopenia: an immunologic study on platelet antibodies dependent on ethylene diamine tetra-acetate.
Antibodies specifically reacting with platelets only in the presence of EDTA, by the platelet immunofluorescence test, were found in the serum of 20 patients with pseudothrombocytopenia due to in vitro EDTA-dependent platelet agglutination, indicating that the reaction is dependent on the antibody-combining site.
A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa.
A donor-dependent difference in electrophoretic mobility of deglycosylated released Fc gamma RIIIa derived from NK cells and macrophages was observed and a significantly different genotype distribution was found among 12 unrelated Caucasian Fc Gamma RIIIB gene-deficient donors.
Autoantibodies against myeloid lysosomal enzymes in crescentic glomerulonephritis.
The results indicate that both vasculitis-associated CGN and idiopathic CGN are associated with autoantibodies against myeloid lysosomal enzymes, which places these disorders within one spectrum of diseases.
Subsets of CD34+ cells and rapid hematopoietic recovery after peripheral-blood stem-cell transplantation.
- M. Dercksen, S. Rodenhuis, C. E. van der Schoot
- Biology, MedicineJournal of clinical oncology : official journal…
- 1 August 1995
The numbers of CD34+CD33- cells and CD34-CD41+ cells may help to predict short-term repopulation capacity of PBSCs, especially when relatively low numbers ofCD34+ cells per kilogram are reinfused.