Pharmacogenetic tests in cancer chemotherapy: what physicians should know for clinical application

@article{Lee2011PharmacogeneticTI,
  title={Pharmacogenetic tests in cancer chemotherapy: what physicians should know for clinical application},
  author={Soo-Youn Lee and Howard L. McLeod},
  journal={The Journal of Pathology},
  year={2011},
  volume={223}
}
Significant efforts to develop pharmacogenomic predictors have been made to guide more effective and safer chemotherapy. Although a considerable amount of data has been generated from numerous experimental or clinical studies, there is a large gap between pharmacogenomic knowledge and clinical application. This review will focus on eight pharmacogenetic tests including TYMS, DPYD, UGT1A1, CYP2D6, EGFR, KRAS, FCGR3A, and BRCA1/2 to predict toxicity or response to commonly used chemotherapeutic… 
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42 Citations
Background Citations
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42 Citations

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Personalized medicine in oncology: where have we come from and where are we going?

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The major findings of pharmacogenomic studies of chemotherapy toxicity during BC management are reassessed and the potential targets of future research are emphasized.

The Role of Genes on the Metabolism of Chemotherapeutic Agents and Their Impact on Toxicity

Understanding the metabolic relationship between genes and chemotherapeutic agents can be used to personalize chemotherapy regimens and ensure that treatment benefits outweigh treatment risks.

Concern for Pharmacogenomics and Autologous Cell Therapy: Can This Be a Direction Toward Medicine for the Future?

Individualized medicine has advanced because researchers have discovered hundreds of genes that harbor variations contributing to human illness and identified genetic variability in patients’ responses to dozens of treatments and have begun to target the molecular causes of some diseases.

Pharmacogenetics, Pharmacogenomics and Ayurgenomics for Personalized Medicine: A Paradigm Shift

  • Pooja Gupta
  • Medicine, Biology
    Indian journal of pharmaceutical sciences
  • 2015
Ayurveda, an exquisitely elaborate system of predictive medicine which has been practiced for over 3500 years in India, can help in bridging this gap in genomics, and Ayurgenomics could complement personalized medicine.

Pharmacovigilance in oncology: evaluation of current practice and future perspectives.

An understanding of the methodologies used by PV in current clinical practice and particularly in cancer drug therapy are provided; a focus upon reporting of ADRs by health professionals and patients; and a focus on methods used to detect new signals of risk/harm related to medicines utilization are provided.

Clinical Pharmacogenetic Testing and Application: Laboratory Medicine Clinical Practice Guidelines

This document contains recommended pharmacogenetic testing guidelines for clinical application, interpretation, and result reporting through a literature review and evidence-based expert opinions for the clinical pharmacogenetics testing covered by public medical insurance in Korea.

miRNA pharmacogenomics: the new frontier for personalized medicine in cancer?

A review of the most recent and promising results in the field of miRNA encoding genes, their targets or factors involved in their maturation are rising as new pharmacogenomic markers in cancer.

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