Pharmacogenetic tests in cancer chemotherapy: what physicians should know for clinical application

@article{Lee2011PharmacogeneticTI,
  title={Pharmacogenetic tests in cancer chemotherapy: what physicians should know for clinical application},
  author={Soo-Youn Lee and Howard L. McLeod},
  journal={The Journal of Pathology},
  year={2011},
  volume={223}
}
Significant efforts to develop pharmacogenomic predictors have been made to guide more effective and safer chemotherapy. Although a considerable amount of data has been generated from numerous experimental or clinical studies, there is a large gap between pharmacogenomic knowledge and clinical application. This review will focus on eight pharmacogenetic tests including TYMS, DPYD, UGT1A1, CYP2D6, EGFR, KRAS, FCGR3A, and BRCA1/2 to predict toxicity or response to commonly used chemotherapeutic… 
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41 Citations
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41 Citations

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