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FAS wt Allele

Known as: Tumor Necrosis Factor Receptor Superfamily, Member 6 Gene, APO-1, APT1 
Human FAS wild-type allele is located in the vicinity of 10q24.1 and is approximately 26 kb in length. This allele, which encodes tumor necrosis… 
National Institutes of Health

Related topics

Related topics

18 relations
10q24.1Alzheimer's Disease Pathway KEGGApoptosisBystander B Cell Activation Pathway

Broader (1)

FAS gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Vorinostat and sorafenib increase ER stress, autophagy and apoptosis via ceramide-dependent CD95 and PERK activation
We recently noted that low doses of sorafenib and vorinostat interact in a synergistic fashion to kill carcinoma cells by… 
Highly Cited
2000
Highly Cited
2000
Inhibition of Death Receptor-mediated Gene Induction by a Cycloheximide-sensitive Factor Occurs at the Level of or Upstream of Fas-associated Death Domain Protein (FADD)*
In HeLa cells, induction of apoptosis and nuclear factor κB (NF-κB) activation initiated by TRAIL/Apo2L or the agonistic Apo1/Fas… 
Highly Cited
2000
Highly Cited
2000
Immune down‐regulation and peripheral deletion of CD8 T cells does not require TNF receptor‐ligand interactions nor CD95 (Fas, APO‐1)
TNF receptor‐ligand interactions and CD95 (Fas / APO‐1) have been demonstrated to be involved in activation‐induced death of… 
Highly Cited
2000
Highly Cited
2000
Immunolocalization of Fas and Fas ligand in the ovaries of women with polycystic ovary syndrome: relationship to apoptosis.
Both Fas (APO-1, CD95), an apoptosis-inducing receptor, and its ligand, Fas ligand (FasL, CD95L), have been localized to the… 
Highly Cited
1999
Highly Cited
1999
Differential involvement of the CD95 (Fas/APO-1) receptor/ligand system on apoptosis induced by the wild-type p53 gene transfer in human cancer cells
The CD95 (Fas/APO-1) system regulates a number of physiological and pathological processes of cell death. The ligand for CD95… 
Highly Cited
1998
Highly Cited
1998
Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas-mediated apoptosis.
The Fas system, comprising the Fas receptor (Fas, CD95, APO-1) and its ligand, Fas ligand (FasL), is a central mediator of… 
Review
1997
Review
1997
Portrait of an executioner: the molecular mechanism of FAS/APO-1-induced apoptosis.
Fas/APO-1 is a member of the TNF receptor family and plays a dominant role in the immune system, down-regulating the immune… 
Highly Cited
1996
Highly Cited
1996
Concurrent engagement of CD40 and the antigen receptor protects naive and memory human B cells from APO-1/Fas-mediated apoptosis
Naive and memory B cells were isolated from human tonsils and examined for expression of APO-1/Fas and for their sensitivity to… 
Highly Cited
1995
Highly Cited
1995
Fas/APO-1 gene transfer for human malignant glioma.
Human malignant glioma cells are susceptible to apoptosis induced by antibodies to Fas/APO-1, a cytokine receptor protein of the… 
Highly Cited
1992
Highly Cited
1992
Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype.
APO-1 is a cell surface molecule that induces apoptosis when ligated with the monoclonal antibody anti-APO-1. Expression of APO-1… 
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