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Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
THE crucial role of the thymus in immunological tolerance1–5 has been demonstrated by establishing that T cells are positively selected to express a specificity for self major histocompatibilityExpand
Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo
Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibodyExpand
CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset.
Natural killer (NK) cells are innate immune lymphocytes that express a heterogeneous repertoire of germline-encoded receptors and undergo a distinct pattern of maturation. CD57 is a marker ofExpand
Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice
To address the mechanisms of tolerance to extrathymic proteins, we have generated transgenic mice expressing the lymphocytic choriomeningitis viral (LCMV) glycoprotein (GP) in the beta islet cells ofExpand
Partial impairment of cytokine responses in Tyk2-deficient mice.
To assess the role of the Janus kinase (Jak) family member Tyk2, we have generated Tyk2-/- mice. In contrast to other Jaks, where inactivation leads to a complete loss of the respective cytokineExpand
Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells
VIRUSES that are non- or poorly cytopathic have developed various strategies to avoid elimination by the immune system and to persist in the host1–3. Acute infection of adult mice with theExpand
Visualization, characterization, and turnover of CD8+ memory T cells in virus-infected hosts
The cellular basis of T cell memory is a controversial issue and progress has been hampered by the inability to induce and to trace long- term memory T cells specific for a defined antigen in vivo.Expand
Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation
Exhausted CD8+ T cell responses during chronic viral infections are defined by a complex expression pattern of inhibitory receptors. However, very little information is currently available about theExpand
Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1).
Adaptive immunity necessitates the proliferation of lymphocytes. In the mouse, we have previously shown that antigen-experienced T cells that have lost their proliferative potential express theExpand
KLRG1 signaling induces defective Akt (ser473) phosphorylation and proliferative dysfunction of highly differentiated CD8+ T cells.
Highly differentiated CD8+CD28-CD27- T cells have short telomeres, defective telomerase activity, and reduced capacity for proliferation, indicating that they are close to replicative senescence. InExpand