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Monoclonal antibody-mediated tumor regression by induction of apoptosis.
TLDR
Histological thin sections of the regressing tumor showed that anti-APO-1 was able to induce apoptosis in vivo, suggesting induction of apoptosis as a consequence of a signal mediated through cell surface molecules like APO- 1 may be a useful therapeutic approach in treatment of malignancy. Expand
Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen.
TLDR
The APO-1 antigen was expressed upon transfection of APo-1 cDNA into BL60-P7 Burkitt's lymphoma cells and conferred sensitivity towards anti-APO- 1-induced apoptosis to the transfectants. Expand
Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens.
TLDR
The data show that selective targeting of apoptosis to tumors may be an efficient antitumor mechanism and suggests that cross-linking of APO-1 on the tumor cell surface may also be required for tumor regression by apoptosis in vivo. Expand
Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype.
TLDR
The sensitivity of lymphoblastoid cell lines to anti-APO-1-mediated apoptosis may open a new therapeutic approach for the treatment of EBV-induced lymphoproliferative lesions in immunocompromised individuals, because these are composed of cells with a lymphobstonoid phenotype. Expand
Expression of the APO-1 antigen in Burkitt lymphoma cell lines correlates with a shift towards a lymphoblastoid phenotype.
TLDR
The sensitivity of lymphoblastoid cell lines to anti-APO-1-mediated apoptosis may open a new therapeutic approach for the treatment of EBV- induced lymphoproliferative lesions in immunocompromised individuals, because these are composed of cells with a lymphobstonoid phenotype. Expand
Apoptosis in the Apo-1 system
TLDR
This research attacked the mode of action of E.P.C.H.’s “cell reprograming” by focusing on the “spatially-based” component of the immune response to cancer. Expand
APO-I-mediated apoptosis in normal and malignant lymphocytes.
Apoptosis in Monoclonal Antibody-Induced Tumor Regression
A variety of cell surface molecules are involved in growth control of normal and malignant cells and transmit lateral or vertical signals regulating cell replication. It is the purpose of ourExpand
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