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Etanidazole

Known as: 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-, 2-Nitroimidazole-1-acetamide, N-(2-hydroxyethyl)-, Etanidazole [Chemical/Ingredient] 
A 2-nitroimidazole with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (3)

2-nitroimidazole EF5SR-2508fluoroetanidazole

Broader (3)

Antineoplastic AgentsNitroimidazolesRadiation-Sensitizing Agents
Glutathione S-TransferaseIn Bloodagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Stereotactic ablative radiotherapy should be combined with a hypoxic cell radiosensitizer.
Highly Cited
2002
Highly Cited
2002
Double-walled microspheres for the sustained release of a highly water soluble drug: characterization and irradiation studies.
Highly Cited
1998
Highly Cited
1998
Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85-27.
Highly Cited
1995
Highly Cited
1995
Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity.
The present studies were initiated to quantitate the oxygen dependence of bioreductive metabolism-induced binding of EF5, a… 
1995
1995
Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350 series): radiosensitization efficiency and toxicity.
Highly Cited
1994
Highly Cited
1994
Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors.
Hypoxic modification by nitroimidazoles has been explored in a large number of clinical studies. Nine different drugs… 
Review
1993
Review
1993
Local hyperthermia, radiation therapy, and chemotherapy in patients with local-regional recurrence of breast carcinoma.
Highly Cited
1993
Highly Cited
1993
Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.
Hypoxic cells in tissue pose many medical problems, and there is a need for more accurate measurements of tissue hypoxia. However… 
Highly Cited
1990
Highly Cited
1990
Classification of antineoplastic treatments by their differential toxicity toward putative oxygenated and hypoxic tumor subpopulations in vivo in the FSaIIC murine fibrosarcoma.
In order to investigate the effect of environmentally determined conditions on the cytotoxicity of anticancer treatments, Hoechst… 
Review
1989
Review
1989
Keynote address: hypoxic cell radiosensitizers: where next?
  • J. Brown
  • International Journal of Radiation Oncology…
  • 1989
  • Corpus ID: 13335389
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