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Etanidazole

Known as: 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-, 2-Nitroimidazole-1-acetamide, N-(2-hydroxyethyl)-, Etanidazole [Chemical/Ingredient] 
A 2-nitroimidazole with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (3)

2-nitroimidazole EF5SR-2508fluoroetanidazole

Broader (3)

Antineoplastic AgentsNitroimidazolesRadiation-Sensitizing Agents
Glutathione S-TransferaseIn Bloodagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Utility of 19F MRS detection of the hypoxic cell marker EF5 to assess cellular hypoxia in solid tumors.
2003
2003
Computer simulation of the delivery of etanidazole to brain tumor from PLGA wafers: comparison between linear and double burst release systems.
This paper presents the computer simulation results on the delivery of Etanidazole (radiosensitizer) to the brain tumor and… 
Highly Cited
2002
Highly Cited
2002
Effects of fabrication conditions on the characteristics of etanidazole spray-dried microspheres
Etanidazole, a hypoxic radiosensitizer, has potential applications in radiotherapy. Due to its high solubility in water, common… 
1999
1999
Detection of hypoxic cells with the 2-nitroimidazole, EF5, correlates with early redox changes in rat brain after perinatal hypoxia–ischemia
Highly Cited
1999
Highly Cited
1999
Characterization of [18F]fluoroetanidazole, a new radiopharmaceutical for detecting tumor hypoxia.
UNLABELLED Fluorinated derivatives of etanidazole are being explored as probes for tumor hypoxia. Our research group has… 
1995
1995
Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350 series): radiosensitization efficiency and toxicity.
Review
1993
Review
1993
Local hyperthermia, radiation therapy, and chemotherapy in patients with local-regional recurrence of breast carcinoma.
1993
1993
Radiosensitization by a new potent nucleoside analog: 1-(1',3',4'-trihydroxy-2'-butoxy)methyl-2-nitroimidazole(RP-343).
1992
1992
Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908.
1991
1991
A fluorinated 2-nitroimidazole, KU-2285, as a new hypoxic cell radiosensitizer.
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