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Etanidazole

Known as: 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-, 2-Nitroimidazole-1-acetamide, N-(2-hydroxyethyl)-, Etanidazole [Chemical/Ingredient] 
A 2-nitroimidazole with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (3)

2-nitroimidazole EF5SR-2508fluoroetanidazole

Broader (3)

Antineoplastic AgentsNitroimidazolesRadiation-Sensitizing Agents
Glutathione S-TransferaseIn Bloodagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Utility of 19F MRS detection of the hypoxic cell marker EF5 to assess cellular hypoxia in solid tumors.
Highly Cited
2002
Highly Cited
2002
Effects of fabrication conditions on the characteristics of etanidazole spray-dried microspheres
Etanidazole, a hypoxic radiosensitizer, has potential applications in radiotherapy. Due to its high solubility in water, common… 
1999
1999
Detection of hypoxic cells with the 2-nitroimidazole, EF5, correlates with early redox changes in rat brain after perinatal hypoxia–ischemia
Highly Cited
1998
Highly Cited
1998
Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85-27.
1995
1995
Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350 series): radiosensitization efficiency and toxicity.
Review
1993
Review
1993
Local hyperthermia, radiation therapy, and chemotherapy in patients with local-regional recurrence of breast carcinoma.
Highly Cited
1993
Highly Cited
1993
Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.
Hypoxic cells in tissue pose many medical problems, and there is a need for more accurate measurements of tissue hypoxia. However… 
1992
1992
Dual function nitroimidazoles less toxic than RSU 1069: selection of candidate drugs for clinical trial (RB 6145 and/or PD 130908.
1991
1991
A fluorinated 2-nitroimidazole, KU-2285, as a new hypoxic cell radiosensitizer.
Review
1989
Review
1989
Keynote address: hypoxic cell radiosensitizers: where next?
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