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Etanidazole

Known as: 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-, 2-Nitroimidazole-1-acetamide, N-(2-hydroxyethyl)-, Etanidazole [Chemical/Ingredient] 
A 2-nitroimidazole with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the… Expand
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (3)

2-nitroimidazole EF5SR-2508fluoroetanidazole

Broader (3)

Antineoplastic AgentsNitroimidazolesRadiation-Sensitizing Agents
Glutathione S-TransferaseIn Bloodagonistsanalogs & derivatives
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Radiosensitization of paclitaxel, etanidazole and paclitaxel+etanidazole nanoparticles on hypoxic human tumor cells in vitro.
Paclitaxel and etanidazole are hypoxic radiosensitizers that exhibit cytotoxic action at different mechanisms. The poly(D,L… Expand
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2005
2005
Etanidazole in pH-sensitive liposomes: design, characterization and in vitro/in vivo anti-Trypanosoma cruzi activity.
In this work, the hydrophilic, low molecular weight and trypanocidal drug etanidazole (ETZ) was loaded in pH-sensitive liposomes… Expand
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Highly Cited
2002
Highly Cited
2002
Sustained release of etanidazole from spray dried microspheres prepared by non-halogenated solvents.
  • F. J. Wang, C. Wang
  • Journal of controlled release : official journal…
  • 2002
    • Corpus ID: 21408381
Etanidazole, a kind of radiosensitizer, was encapsulated in the spray-dried microspheres using biodegradable polymer PLGA 65:35… Expand
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Highly Cited
1998
Highly Cited
1998
Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85-27.
PURPOSE The purpose of the present study is to investigate the strength of association between anemia and overall survival… Expand
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1997
1997
Results of a European randomized trial of Etanidazole combined with radiotherapy in head and neck carcinomas.
PURPOSE The aim of the study was to evaluate the efficacy and toxicity of Etanidazole, a hypoxic cell sensitizer, combined with… Expand
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Highly Cited
1995
Highly Cited
1995
Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas.
PURPOSE The objectives of this study were to determine the efficacy and toxicity of Etanidazole (ETA), a hypoxic cell sensitizer… Expand
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Highly Cited
1995
Highly Cited
1995
Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity.
The present studies were initiated to quantitate the oxygen dependence of bioreductive metabolism-induced binding of EF5, a… Expand
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Highly Cited
1995
Highly Cited
1995
RTOG's first quality of life study--RTOG 90-20: a phase II trial of external beam radiation with etanidazole for locally advanced prostate cancer.
PURPOSE To assess institutional and patient compliance with quality of life (QL) instruments in RTOG clinical trials. To assess… Expand
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Highly Cited
1994
Highly Cited
1994
Clinical evaluation of nitroimidazoles as modifiers of hypoxia in solid tumors.
Hypoxic modification by nitroimidazoles has been explored in a large number of clinical studies. Nine different drugs… Expand
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Highly Cited
1993
Highly Cited
1993
Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.
Hypoxic cells in tissue pose many medical problems, and there is a need for more accurate measurements of tissue hypoxia. However… Expand
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