Etanidazole

Known as: 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-, 2-Nitroimidazole-1-acetamide, N-(2-hydroxyethyl)-, Etanidazole [Chemical/Ingredient] 
A 2-nitroimidazole with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the… (More)
National Institutes of Health

Related topics

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15 relations

Narrower (3)

2-nitroimidazole EF5SR-2508fluoroetanidazole

Broader (3)

Antineoplastic AgentsNitroimidazolesRadiation-Sensitizing Agents
Glutathione S-TransferaseIn Bloodagonistsanalogs & derivatives
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Papers overview

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2007
2007
Radiosensitization of paclitaxel, etanidazole and paclitaxel+etanidazole nanoparticles on hypoxic human tumor cells in vitro.
Paclitaxel and etanidazole are hypoxic radiosensitizers that exhibit cytotoxic action at different mechanisms. The poly(D,L… (More)
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2007
2007
In vivo performance of implantable biodegradable preparations delivering Paclitaxel and Etanidazole for the treatment of glioma.
Drug-releasing implants delivering chemotherapeutic and radio-sensitizing agents are beginning to play a major role in the post… (More)
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2002
2002
Sustained release of etanidazole from spray dried microspheres prepared by non-halogenated solvents.
Etanidazole, a kind of radiosensitizer, was encapsulated in the spray-dried microspheres using biodegradable polymer PLGA 65:35… (More)
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2002
2002
Effects of fabrication conditions on the characteristics of etanidazole spray-dried microspheres.
Etanidazole, a hypoxic radiosensitizer, has potential applications in radiotherapy. Due to its high solubility in water, common… (More)
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Highly Cited
1998
Highly Cited
1998
Anemia is associated with decreased survival and increased locoregional failure in patients with locally advanced head and neck carcinoma: a secondary analysis of RTOG 85-27.
PURPOSE The purpose of the present study is to investigate the strength of association between anemia and overall survival… (More)
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1997
1997
A phase I trial of etanidazole and hyperfractionated radiotherapy in children with diffuse brainstem glioma.
PURPOSE To determine the toxicity and maximum tolerated dose of etanidazole administered concurrently with hyperfractionated… (More)
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Highly Cited
1995
Highly Cited
1995
Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity.
The present studies were initiated to quantitate the oxygen dependence of bioreductive metabolism-induced binding of EF5, a… (More)
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1994
1994
Results of an RTOG phase III trial (RTOG 85-27) comparing radiotherapy plus etanidazole with radiotherapy alone for locally advanced head and neck carcinomas.
PURPOSE The objectives of this study were to determine the efficacy and toxicity of Etanidazole (ETA), a hypoxic cell sensitizer… (More)
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Highly Cited
1993
Highly Cited
1993
Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.
Hypoxic cells in tissue pose many medical problems, and there is a need for more accurate measurements of tissue hypoxia. However… (More)
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Highly Cited
1990
Highly Cited
1990
Classification of antineoplastic treatments by their differential toxicity toward putative oxygenated and hypoxic tumor subpopulations in vivo in the FSaIIC murine fibrosarcoma.
In order to investigate the effect of environmentally determined conditions on the cytotoxicity of anticancer treatments, Hoechst… (More)
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