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SIMULTANEOUS ESTABLISHMENT OF MONOCLONAL ANTIBODIES SPECIFIC FOR EITHER CYCLOBUTANE PYRIMIDINE DIMER OR (6‐4)PHOTOPRODUCT FROM THE SAME MOUSE IMMUNIZED WITH ULTRAVIOLET‐IRRADIATED DNA
TLDR
The first report of the simultaneous establishment of monoclonal antibodies against the two different types of photolesions from the same mouse is reported, which indicated that the epitope of 64M antibodies was the (6‐4)photoproduct in DNA. Expand
Role of Iron and Superoxide for Generation of Hydroxyl Radical, Oxidative DNA Lesions, and Mutagenesis in Escherichia coli *
TLDR
Excess iron and excess superoxide were responsible for OH⋅ generation, oxidative DNA lesion formation, and hypermutability in E. coli. Expand
Supranuclear melanin caps reduce ultraviolet induced DNA photoproducts in human epidermis.
TLDR
Melanin reduces ultraviolet induced DNA photoproducts in human epidermal cells in a concentration dependent manner, suggesting that intracellular melan in reduces ultraviolet transmission to underlying cell nuclei and inhibits the formation of ultraviolet inducedDNA photopProducts. Expand
Possible involvement of ERK 1/2 in UVA-induced melanogenesis in cultured normal human epidermal melanocytes.
TLDR
Findings suggest that a single UVA irradiation-induced melanogenesis is associated with the activation of ERK1/2 by upstream signals that originate from reactive oxygen species or from activated tyrosine kinase receptors, but not from damaged DNA. Expand
Differential apoptotic pathways in human keratinocyte HaCaT cells exposed to UVB and UVC
TLDR
The results clearly suggest that the reason apoptosis is induced to the same extent by UVB irradiation as by UVC irradiation, despite the lower production of photoproducts in DNA by UVBs, is attributable to the additional activation of the caspase-8 pathway. Expand
Quantitation and visualization of ultraviolet-induced DNA damage using specific antibodies: application to pigment cell biology.
TLDR
The DNA repair kinetics following irradiation of human cell nuclei and the photoprotective effect of melanin against DNA photoproducts in cultured pigmented cells and in human epidermis are described. Expand
Three-dimensional visualization of ultraviolet-induced DNA damage and its repair in human cell nuclei.
TLDR
The present results suggest that both 6-4PP and CPD are nonrandomly repaired from nuclei in normal human cells. Expand
Differential behaviors toward ultraviolet A and B radiation of fibroblasts and keratinocytes from normal and DNA-repair-deficient patients.
TLDR
Unscheduled DNA synthesis at UV doses leading to 50% cell survival indicated that the ratio of DNA repair capacity to cell survival is higher in keratinocytes than in fibroblasts, and UVA and UVB irradiation induced a transition from proliferative to abortive keratinocyte colonies, which varied between donors and was in part correlated with their cancer susceptibility. Expand
A newly identified patient with clinical xeroderma pigmentosum phenotype has a non-sense mutation in the DDB2 gene and incomplete repair in (6-4) photoproducts.
TLDR
The results suggest that the DDB2 gene is somewhat related to skin carcinogenesis, photoaging skin, and the removal of (6-4) photoproducts, and although it is believed that cyclobutane pyrimidine dimers are the principal mutagenic lesion and ( 6-4). Expand
Histochemical detection of DNA strand scissions in mammalian cells by in situ nick translation.
  • S. Iseki, T. Mori
  • Biology, Medicine
  • Cell biology international reports
  • 1 May 1985
TLDR
The nuclei of HeLa cells which had been treated with a DNA-damaging antibiotic bleomycin were specifically stained, implicating that the histochemical detection of single strand scissions (nicks) of DNA in fixed cells was completed without destroying the morphology, and without using autoradiography. Expand
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