2-nitroimidazole EF5

Known as: EF5, compound EF5, EF5 compound 
A fluorinated derivative of the 2-nitroimidazole etanidazole. EF5 is effective in accessing oxygen levels in tumor tissue through its adduct… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
UNLABELLED The aim of this study was to evaluate 2-(2-nitro-(1)H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)-acetamide (EF5… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE Anticancer drugs gain access to solid tumors via the circulatory system and must penetrate the tissue to kill cancer… (More)
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Highly Cited
2004
Highly Cited
2004
Hypoxia is known to be an important prognostic marker in many human cancers. We report the use of two oxygen measurement… (More)
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Highly Cited
2004
Highly Cited
2004
We investigated whether increasing levels of tissue hypoxia, measured by the binding of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2… (More)
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Review
2002
Review
2002
We have established basic methods, using quantitative measures of EF5 binding, to estimate the actual pO2 of cells and tissues… (More)
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2002
2002
Tumor hypoxia is an important prognostic indicator for cancer therapy outcome. EF5 {2-(2-nitro-1[H]-imidazol-1-yl)-N-(2,2,3,3,3… (More)
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Highly Cited
2000
Highly Cited
2000
Localization and quantitation of 2-nitroimidazole drug binding in low pO2 tumors is a technique that can allow the assessment of… (More)
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Highly Cited
1998
Highly Cited
1998
The transcriptional response to lowered oxygen levels is mediated by the hypoxia-inducible transcription factor (HIF-1), a… (More)
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Highly Cited
1995
Highly Cited
1995
The present studies were initiated to quantitate the oxygen dependence of bioreductive metabolism-induced binding of EF5, a… (More)
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Highly Cited
1993
Highly Cited
1993
Hypoxic cells in tissue pose many medical problems, and there is a need for more accurate measurements of tissue hypoxia. However… (More)
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