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2-nitroimidazole EF5

Known as: EF5, compound EF5, EF5 compound 
A fluorinated derivative of the 2-nitroimidazole etanidazole. EF5 is effective in accessing oxygen levels in tumor tissue through its adduct… 
National Institutes of Health

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Etanidazole

Papers overview

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2009
2009
Altered hypoxia‐inducible factor‐1 alpha expression levels correlate with coronary vessel anomalies
The outflow tract myocardium and other regions corresponding to the location of the major coronary vessels of the developing… 
Highly Cited
2008
Highly Cited
2008
Suppression of VEGF secretion and changes in glioblastoma multiforme microenvironment by inhibition of Integrin-linked kinase (ILK)
Integrin-linked kinase (ILK) was assesed as a therapeutic target in glioblastoma xenograft models through multiple endpoints… 
2007
2007
Non‐invasive evaluation of tumour hypoxia in the Shionogi tumour model for prostate cancer with 18F‐EF5 and positron emission tomography
To evaluate hypoxia non‐invasively in androgen‐dependent (AD), regressing (6‐days after castration, RG) and androgen‐independent… 
Highly Cited
2004
Highly Cited
2004
Hypoxia and Photofrin Uptake in the Intraperitoneal Carcinomatosis and Sarcomatosis of Photodynamic Therapy Patients
Purpose: Response to photodynamic therapy depends on adequate tumor oxygenation as well as sufficient accumulation of… 
2004
2004
2,3,7,8-tetrachlorodibenzo-p-dioxin reduces myocardial hypoxia and vascular endothelial growth factor expression during chick embryo development.
BACKGROUND Previous research has demonstrated that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces cardiomyocyte growth arrest… 
Review
2003
Review
2003
Non-invasive PET and SPECT imaging of tissue hypoxia using isotopically labeled 2-nitroimidazoles.
The measurement of pathologically low levels of tissue pO2 is an important diagnostic goal for determining the prognosis of many… 
Review
2002
Review
2002
Farnesyltransferase inhibitors as radiation sensitizers.
PURPOSE The inhibition of activated Ras combined with radiotherapy was identified as a potential method for radiosensitization… 
Highly Cited
2001
Highly Cited
2001
Combined Prostaglandin and Nitric Oxide Inhibition Produces Anatomic Remodeling and Closure of the Ductus Arteriosus in the Premature Newborn Baboon
After birth, the full-term ductus arteriosus actively constricts and undergoes extensive histologic changes that prevent… 
1997
1997
Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia.
Tirapazamine (TPZ) is a hypoxia-selective bioreductive drug currently in Phases II and III clinical trials with both radiotherapy… 
1975
1975
On homo- and heterothallism in Schizosaccharomyces pombe.
The mating-type system of Schizosaccharomyces pombe has previously been studied by Leupold. In his culture, Leupold found… 
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