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Eflornithine

Known as: DFMO, Difluromethylornithine, (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid 
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required… 
National Institutes of Health

Related topics

Related topics

33 relations

Narrower (6)

2-(fluoromethyl)dehydroornithine methyl ester2-fluoromethylornithineEflornithine HydrochlorideOrnidyl
African TrypanosomiasisAntiprotozoal AgentsApoptosisDecarboxylase Inhibitors [MoA]

Broader (3)

Antineoplastic AgentsOrnithine Decarboxylase InhibitorsTrypanocidal Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the… 
Highly Cited
2008
Highly Cited
2008
Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial
Abstract Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing… 
Review
2003
Review
2003
A perspective of polyamine metabolism.
Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both… 
Review
2002
Review
2002
Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues.
Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs… 
Review
2002
Review
2002
Eflornithine for the treatment of human African trypanosomiasis
Abstract. Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50… 
Highly Cited
1997
Highly Cited
1997
The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro.
Highly Cited
1990
Highly Cited
1990
Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor…
The effect of three levels of piroxicam and three levels of D,L-alpha-difluoromethylornithine (DFMO) fed individually and in… 
Review
1982
Review
1982
Polyamine metabolism and function.
Polyamines are ubiquitous organic cations of low molecular weight. The content of these amines is closely regulated by the cell… 
Highly Cited
1980
Highly Cited
1980
Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats.
A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the… 
Highly Cited
1978
Highly Cited
1978
Anti-proliferative properties of DL-alpha-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase.
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