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Eflornithine
Known as:
DFMO
, Difluromethylornithine
, (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid
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A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required…
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National Institutes of Health
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Related topics
Related topics
33 relations
Narrower (6)
2-(fluoromethyl)dehydroornithine methyl ester
2-fluoromethylornithine
Eflornithine Hydrochloride
Ornidyl
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African Trypanosomiasis
Antiprotozoal Agents
Apoptosis
Decarboxylase Inhibitors [MoA]
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Broader (3)
Antineoplastic Agents
Ornithine Decarboxylase Inhibitors
Trypanocidal Agents
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes
Isabel M. Vincent
,
D. Creek
,
+5 authors
M. Barrett
PLoS pathogens
2010
Corpus ID: 16676518
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the…
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Highly Cited
2008
Highly Cited
2008
Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial
F. Meyskens
,
C. McLaren
,
+15 authors
E. Gerner
Cancer Prevention Research
2008
Corpus ID: 6509285
Abstract Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing…
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Review
2003
Review
2003
A perspective of polyamine metabolism.
H. Wallace
,
A. Fraser
,
A. Hughes
The Biochemical journal
2003
Corpus ID: 33264555
Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both…
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Review
2002
Review
2002
Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues.
M. Thun
,
S. J. Henley
,
C. Patrono
Journal of the National Cancer Institute
2002
Corpus ID: 3934216
Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs…
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Review
2002
Review
2002
Eflornithine for the treatment of human African trypanosomiasis
C. Burri
,
R. Brun
Parasitology Research
2002
Corpus ID: 35509112
Abstract. Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50…
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Highly Cited
1997
Highly Cited
1997
The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro.
B. Räz
,
M. Iten
,
Y. Grether-Bühler
,
R. Kaminsky
,
R. Brun
Acta tropica
1997
Corpus ID: 35461407
Highly Cited
1990
Highly Cited
1990
Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor…
B. Reddy
,
J. Nayini
,
K. Tokumo
,
J. Rigotty
,
E. Zang
,
G. Kelloff
Cancer research
1990
Corpus ID: 21249443
The effect of three levels of piroxicam and three levels of D,L-alpha-difluoromethylornithine (DFMO) fed individually and in…
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Review
1982
Review
1982
Polyamine metabolism and function.
A. Pegg
,
P. McCann
The American journal of physiology
1982
Corpus ID: 21063248
Polyamines are ubiquitous organic cations of low molecular weight. The content of these amines is closely regulated by the cell…
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Highly Cited
1980
Highly Cited
1980
Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats.
G. Lux
,
L. Marton
,
S. Baylin
Science
1980
Corpus ID: 38998854
A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the…
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Highly Cited
1978
Highly Cited
1978
Anti-proliferative properties of DL-alpha-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase.
P. Mamont
,
M. Duchesne
,
J. Grove
,
P. Bey
Biochemical and biophysical research…
1978
Corpus ID: 2524566
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