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Eflornithine

Known as: DFMO, Difluromethylornithine, (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid 
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required… Expand
National Institutes of Health

Related topics

Related topics

33 relations

Narrower (6)

2-(fluoromethyl)dehydroornithine methyl ester2-fluoromethylornithineEflornithine HydrochlorideOrnidyl
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African TrypanosomiasisAntiprotozoal AgentsApoptosisDecarboxylase Inhibitors [MoA]
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Broader (3)

Antineoplastic AgentsOrnithine Decarboxylase InhibitorsTrypanocidal Agents

Papers overview

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Highly Cited
2011
Highly Cited
2011
A new method for aromatic difluoromethylation: copper-catalyzed cross-coupling and decarboxylation sequence from aryl iodides.
A new methodology for aromatic difluoromethylation is described. Aryl iodides reacted with α-silyldifluoroacetates upon treatment… Expand
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Highly Cited
2010
Highly Cited
2010
A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the… Expand
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Highly Cited
2008
Highly Cited
2008
Difluoromethylornithine Plus Sulindac for the Prevention of Sporadic Colorectal Adenomas: A Randomized Placebo-Controlled, Double-Blind Trial
Abstract Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing… Expand
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Highly Cited
2005
Highly Cited
2005
STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.
Activation of STAT3 (signal transducer and activator of transcription 3) plays a crucial role in cell survival and proliferation… Expand
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Review
2003
Review
2003
A perspective of polyamine metabolism.
Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both… Expand
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Review
2002
Review
2002
Eflornithine for the treatment of human African trypanosomiasis
Abstract. Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50… Expand
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Highly Cited
1997
Highly Cited
1997
The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro.
Alamar Blue, an indicator for metabolic cell function, was evaluated as a fluorescent and as a colorimetric dye in drug… Expand
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Highly Cited
1990
Highly Cited
1990
Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor…
The effect of three levels of piroxicam and three levels of D,L-alpha-difluoromethylornithine (DFMO) fed individually and in… Expand
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Review
1982
Review
1982
Polyamine metabolism and function.
Polyamines are ubiquitous organic cations of low molecular weight. The content of these amines is closely regulated by the cell… Expand
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Highly Cited
1980
Highly Cited
1980
Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats.
A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the… Expand
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