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Eflornithine

Known as: DFMO, Difluromethylornithine, (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid 
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
A new methodology for aromatic difluoromethylation is described. Aryl iodides reacted with α-silyldifluoroacetates upon treatment… Expand
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Highly Cited
2010
Highly Cited
2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the… Expand
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Highly Cited
2008
Highly Cited
2008
Abstract Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing… Expand
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Highly Cited
2005
Highly Cited
2005
Activation of STAT3 (signal transducer and activator of transcription 3) plays a crucial role in cell survival and proliferation… Expand
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Review
2003
Review
2003
Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both… Expand
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Review
2002
Review
2002
Abstract. Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50… Expand
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Highly Cited
1997
Highly Cited
1997
Alamar Blue, an indicator for metabolic cell function, was evaluated as a fluorescent and as a colorimetric dye in drug… Expand
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Highly Cited
1990
Highly Cited
1990
The effect of three levels of piroxicam and three levels of D,L-alpha-difluoromethylornithine (DFMO) fed individually and in… Expand
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Review
1982
Review
1982
Polyamines are ubiquitous organic cations of low molecular weight. The content of these amines is closely regulated by the cell… Expand
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Highly Cited
1980
Highly Cited
1980
A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the… Expand
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