Eflornithine

Known as: DFMO, Difluromethylornithine, (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid 
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the… (More)
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Highly Cited
2005
Highly Cited
2005
Activation of STAT3 (signal transducer and activator of transcription 3) plays a crucial role in cell survival and proliferation… (More)
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Review
2003
Review
2003
Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both… (More)
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Review
2002
Review
2002
Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is… (More)
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Review
2001
Review
2001
Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase which is thought to slow hair growth by… (More)
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Highly Cited
1994
Highly Cited
1994
The mRNAs for two key enzymes in polyamine biosynthesis, ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase… (More)
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Highly Cited
1990
Highly Cited
1990
The effect of three levels of piroxicam and three levels of D,L-alpha-difluoromethylornithine (DFMO) fed individually and in… (More)
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Highly Cited
1984
Highly Cited
1984
Embryogenic cultures of Daucus carota treated with 1 millimolar alpha-difluoromethylarginine, a specific inhibitor of arginine… (More)
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Review
1982
Review
1982
Polyamines are ubiquitous organic cations of low molecular weight. The content of these amines is closely regulated by the cell… (More)
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Highly Cited
1980
Highly Cited
1980
A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the… (More)
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