Eflornithine

Known as: DFMO, Difluromethylornithine, (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid 
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required… (More)
National Institutes of Health

Related topics

Related topics

32 relations

Narrower (6)

2-(fluoromethyl)dehydroornithine methyl ester2-fluoromethylornithineEflornithine HydrochlorideOrnidyl
(More)
African TrypanosomiasisAntiprotozoal AgentsApoptosisDecarboxylase Inhibitors [MoA]
(More)

Broader (3)

Antineoplastic AgentsOrnithine Decarboxylase InhibitorsTrypanocidal Agents

Papers overview

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Highly Cited
2010
Highly Cited
2010
A Molecular Mechanism for Eflornithine Resistance in African Trypanosomes
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the… (More)
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Highly Cited
2005
Highly Cited
2005
STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.
Activation of STAT3 (signal transducer and activator of transcription 3) plays a crucial role in cell survival and proliferation… (More)
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Review
2003
Review
2003
A perspective of polyamine metabolism.
Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both… (More)
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Review
2002
Review
2002
Eflornithine for the treatment of human African trypanosomiasis
Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is… (More)
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Review
2001
Review
2001
Topical eflornithine.
Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase which is thought to slow hair growth by… (More)
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Highly Cited
1994
Highly Cited
1994
Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation.
The mRNAs for two key enzymes in polyamine biosynthesis, ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase… (More)
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Highly Cited
1990
Highly Cited
1990
Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor…
The effect of three levels of piroxicam and three levels of D,L-alpha-difluoromethylornithine (DFMO) fed individually and in… (More)
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Highly Cited
1984
Highly Cited
1984
Arginine decarboxylase and polyamines required for embryogenesis in the wild carrot.
Embryogenic cultures of Daucus carota treated with 1 millimolar alpha-difluoromethylarginine, a specific inhibitor of arginine… (More)
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Review
1982
Review
1982
Polyamine metabolism and function.
Polyamines are ubiquitous organic cations of low molecular weight. The content of these amines is closely regulated by the cell… (More)
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Highly Cited
1980
Highly Cited
1980
Ornithine decarboxylase is important in intestinal mucosal maturation and recovery from injury in rats.
A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the… (More)
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