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Eflornithine

Known as: DFMO, Difluromethylornithine, (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid 
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required… 
National Institutes of Health

Related topics

Related topics

33 relations

Narrower (6)

2-(fluoromethyl)dehydroornithine methyl ester2-fluoromethylornithineEflornithine HydrochlorideOrnidyl
African TrypanosomiasisAntiprotozoal AgentsApoptosisDecarboxylase Inhibitors [MoA]

Broader (3)

Antineoplastic AgentsOrnithine Decarboxylase InhibitorsTrypanocidal Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1986
1986
Comparison of the biological effects of four irreversible inhibitors of ornithine decarboxylase in two murine lymphocytic leukemia cell lines.
The effects of the enzyme-activated irreversible inhibitors of ornithine decarboxylase, alpha-difluoromethylornithine, alpha… 
Highly Cited
1986
Highly Cited
1986
Altered cell cycle phase distributions in cultured human carcinoma cells partially depleted of polyamines by treatment with difluoromethylornithine.
We have studied the effects of partial polyamine depletion, induced by treatment with alpha-difluoromethylornithine (DFMO) on… 
Highly Cited
1985
Highly Cited
1985
Accumulation of ornithine decarboxylase-antizyme complex in HMOA cells.
A new method was developed for the assay of ornithine decarboxylase (ODC)-antizyme complex, in which alpha… 
Highly Cited
1984
Highly Cited
1984
Polyamines as mediators of estrogen action on the growth of experimental breast cancer in rats.
The role of polyamines as mediators of the mitogenic effect of 17 beta-estradiol (E2) was investigated in the N-nitrosomethylurea… 
Highly Cited
1983
Highly Cited
1983
Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells.
Depletion of polyamines in 9L rat brain tumor cells by treatment with alpha-difluoromethylornithine dramatically altered DNA… 
1983
1983
Effects of α-Difluoromethylornithine and 5-Fluorouracil on the Proliferation of a Human Colon Adenocarcinoma Cell Line
Because α-difluoromethylornithine (DFMO) reduces the incidence of experimental colon cancers, inhibits the growth of human lung… 
Highly Cited
1982
Highly Cited
1982
Autoradiographic identification of ornithine decarboxylase in mouse kidney by means of alpha-[5-14C]difluoromethylornithine.
alpha-Difluoromethylornithine is an enzyme-activated irreversible inhibitor of ornithine decarboxylase that forms a covalent bond… 
1982
1982
An essential role for polyamine biosynthesis during human granulopoietic differentiation.
The role of polyamines during the process of colony-stimulating factor-induced proliferation and differentiation of human… 
Highly Cited
1979
Highly Cited
1979
Suppression of the formation of polyamines and macromolecules by DL-alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in phytohaemagglutinin-activated human lymphocytes.
1. The activation of human peripheral blood lymphocytes by phytohaemagglutinin in vitro was accompanied by striking increases in… 
Highly Cited
1979
Highly Cited
1979
Effects of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor or ornithine decarboxylase, on testosterone-induced regeneration of prostate and seminal vesicle in castrated rats…
1. Castration of adult rats markedly decreases the amounts of polyamines (putrescine, spermidine and spermine) and of RNA and DNA…