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Eflornithine

Known as: DFMO, Difluromethylornithine, (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid 
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Human African trypanosomiasis, endemic to sub-Saharan Africa, is invariably fatal if untreated. Its causative agent is the… 
Highly Cited
2008
Highly Cited
2008
Abstract Preclinical studies of chemoprevention drugs given in combination at low doses show remarkable efficacy in preventing… 
Review
2003
Review
2003
Polyamines are essential for the growth and function of normal cells. They interact with various macromolecules, both… 
Review
2002
Review
2002
Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs… 
Review
2002
Review
2002
Abstract. Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50… 
Highly Cited
1990
Highly Cited
1990
The effect of three levels of piroxicam and three levels of D,L-alpha-difluoromethylornithine (DFMO) fed individually and in… 
Review
1982
Review
1982
Polyamines are ubiquitous organic cations of low molecular weight. The content of these amines is closely regulated by the cell… 
Highly Cited
1980
Highly Cited
1980
A transient increase in ornithine decarboxylase activity and polyamine biosynthesis occurs in the intestinal mucosa of the…