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Eflornithine

Known as: DFMO, Difluromethylornithine, (RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid 
A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required… 
National Institutes of Health

Related topics

Related topics

33 relations

Narrower (6)

2-(fluoromethyl)dehydroornithine methyl ester2-fluoromethylornithineEflornithine HydrochlorideOrnidyl
African TrypanosomiasisAntiprotozoal AgentsApoptosisDecarboxylase Inhibitors [MoA]

Broader (3)

Antineoplastic AgentsOrnithine Decarboxylase InhibitorsTrypanocidal Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Polyamine Depletion Increases Cytoplasmic Levels of RNA-binding Protein HuR Leading to Stabilization of Nucleophosmin and p53 mRNAs*
Polyamines are essential for maintaining normal intestinal epithelial integrity, an effect that relies, at least in part, on… 
Review
2003
Review
2003
Thirty years of polyamine-related approaches to cancer therapy. Retrospect and prospect. Part 1. Selective enzyme inhibitors.
As soon as the natural polyamines (PAs), putrescine (Put), spermidine (Spd) and spermine (Spm), were recognized as ubiquitous… 
Highly Cited
1990
Highly Cited
1990
Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor…
The effect of three levels of piroxicam and three levels of D,L-alpha-difluoromethylornithine (DFMO) fed individually and in… 
Highly Cited
1984
Highly Cited
1984
Involvement of histamine in growth of mouse and rat tumors: antitumoral properties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase.
The present study suggests that newly synthesized histamine is involved in the development of some animal tumors (e.g., Lewis… 
Highly Cited
1983
Highly Cited
1983
Changes in mouse kidney ornithine decarboxylase activity are brought about by changes in the amount of enzyme protein as measured by radioimmunoassay.
Highly Cited
1983
Highly Cited
1983
Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine biosynthesis by alpha-difluoromethylornithine.
Application of the tumor-promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) to mouse skin leads to a manifold induction… 
Highly Cited
1980
Highly Cited
1980
Inhibition of EMT6 tumor growth by interference with polyamine biosynthesis; effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
Highly Cited
1980
Highly Cited
1980
Role of ornithine decarboxylase in cardiac growth and hypertrophy.
Inhibition of cardiac ornithine decarboxylase (ODC) by alpha-difluoromethylornithine (DFMO) did not prevent normal cardiac growth… 
Highly Cited
1978
Highly Cited
1978
Anti-proliferative properties of DL-alpha-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase.
Highly Cited
1978
Highly Cited
1978
Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice.
Abstract α-Difluoromethylornithine monohydrochloride (α-DFMO), an enzyme-activated irreversible inhibitor of ornithine… 
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