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Ornithine Decarboxylase Inhibitors

Known as: Decarboxylase Inhibitors, Ornithine, Inhibitors, Ornithine Decarboxylase, Ornithine Decarboxylase Inhibitor 
Any substance that inhibits ornithine decarboxylase, an enzyme that catalyzes the decarboxylation of ornithine, the rate-limiting, commiting reaction… Expand
National Institutes of Health

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18 relations

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1-aminooxy-3-aminopropane1-aminooxy-4-aminobutane2-(fluoromethyl)dehydroornithine methyl ester2-amino-5-iodoacetamidopentanoic acid
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In Bloodaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor α-difluoromethylornithine (DFMO) in human breast cancer cells
We have shown that inhibition of polyamine biosynthesis with α-difluoromethylornithine (DFMO) reduces in vitro invasiveness and… Expand
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1996
1996
In vivo trypanocidal activities of new S-adenosylmethionine decarboxylase inhibitors.
A series of novel aromatic derivatives based on the structure of methylglyoxal bis(guanylhydrazone) (MGBG) was examined for… Expand
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1992
1992
Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.
The compound 5'-([(Z)-4-amino-2-butenyl]methylamino)-5'-deoxyadenosine (MDL73811), a potent inhibitor of S-adenosylmethionine… Expand
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Highly Cited
1990
Highly Cited
1990
Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug with D,L-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor…
The effect of three levels of piroxicam and three levels of D,L-alpha-difluoromethylornithine (DFMO) fed individually and in… Expand
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1987
1987
Plasmodium falciparum and Plasmodium berghei: effects of ornithine decarboxylase inhibitors on erythrocytic schizogony.
Five ornithine decarboxylase inhibitors: alpha-difluoromethylornithine (DFMO) (eflornithine); alpha-monofluoromethyl-3,4… Expand
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1987
1987
Impairment of macrophage function by inhibitors of ornithine decarboxylase activity.
The effects of irreversible inhibition of ornithine decarboxylase on the capacity of murine macrophages to take up a protozoan… Expand
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1985
1985
Ornithine decarboxylase inhibitors increase the cellular content of the enzyme: implications for translational regulation.
Ehrlich ascites tumor cells grown in the presence of inhibitors of ornithine decarboxylase (EC 4.1.1.17) exhibited an elevated… Expand
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Highly Cited
1984
Highly Cited
1984
Involvement of histamine in growth of mouse and rat tumors: antitumoral properties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase.
The present study suggests that newly synthesized histamine is involved in the development of some animal tumors (e.g., Lewis… Expand
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1982
1982
Ornithine decarboxylase: essential in proliferation but not differentiation of human promyelocytic leukemia cells.
The ornithine decarboxylase inhibitor DL-alpha-difluoromethyl ornithine inhibited a proliferation-associated increase in… Expand
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1981
1981
Potentiation of the antitumor therapeutic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.
alpha-Difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase, was used alone and… Expand
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