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Ornithine Decarboxylase Inhibitors

Known as: Decarboxylase Inhibitors, Ornithine, Inhibitors, Ornithine Decarboxylase, Ornithine Decarboxylase Inhibitor 
Any substance that inhibits ornithine decarboxylase, an enzyme that catalyzes the decarboxylation of ornithine, the rate-limiting, commiting reaction… 
National Institutes of Health

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Narrower (14)

1-aminooxy-3-aminopropane1-aminooxy-4-aminobutane2-(fluoromethyl)dehydroornithine methyl ester2-amino-5-iodoacetamidopentanoic acid
In Bloodaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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Review
2006
Review
2006
Contemporary medical therapy for polycystic ovary syndrome
2004
2004
Cellular mechanisms mediating the anti-invasive properties of the ornithine decarboxylase inhibitor α-difluoromethylornithine (DFMO) in human breast cancer cells
We have shown that inhibition of polyamine biosynthesis with α-difluoromethylornithine (DFMO) reduces in vitro invasiveness and… 
1999
1999
The pathogenesis and modulation of the post-treatment reactive encephalopathy in a mouse model of Human African Trypanosomiasis
1996
1996
Polyamine content of Pneumocystis carinii and response to the ornithine decarboxylase inhibitor DL-alpha-difluoromethylornithine
Difluoromethylornithine (DFMO; eflornithine hydrochloride [Ornidyl]), a suicide inhibitor of the key polyamine biosynthesis… 
1990
1990
Inhibition of the dimorphic transition of Candida albicans by the ornithine decarboxylase inhibitor 1,4-diaminobutanone: alterations in the glycoprotein composition of the cell wall.
Hyphal development in Candida albicans was selectively blocked by the ornithine decarboxylase competitive inhibitor 1,4… 
Highly Cited
1989
Highly Cited
1989
Differential response to treatment with the bis(ethyl)polyamine analogues between human small cell lung carcinoma and undifferentiated large cell lung carcinoma in culture.
1988
1988
Regulation of mammalian S-adenosylmethionine decarboxylase.
1987
1987
Inhibition of polyamine oxidase improves the antitumoral effect of ornithine decarboxylase inhibitors.
Specific inhibition of ornithine decarboxylase activity prevents the formation of putrescine from ornithine and decreases… 
1985
1985
Independent regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in methylthioadenosine phosphorylase-deficient malignant murine lymphoblasts.
The control of polyamine synthesis in neoplastic cells is complex and incompletely understood. Using murine lymphoma cells… 
1985
1985
Disruption of the blood‐brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluoromethyl ornithine
Both hyperammonemia and blood‐brain barrier (BBB) breakdown have been implicated in the evolution of hepatic encephalopathy. To… 
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