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1-aminooxy-3-aminopropane

Known as: 1-Propanamine, 3-(aminooxy)-, 3-aminooxy-1-propanamine 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Ornithine Decarboxylase InhibitorsPropylamines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Pharmacological properties of the ornithine decarboxylase inhibitor 3-aminooxy-1-propanamine and several structural analogues
Analogues of 3-aminooxy-1-propanamine proved to be highly potent and selective inhibitors of ornithine decarboxylase (ODC). The… Expand
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2003
2003
The putrescine analogue 1-aminooxy-3-aminopropane perturbs polyamine metabolism in the phytopathogenic fungus Sclerotinia sclerotiorum
AbstractThe effects of the putrescine analogue 1-aminooxy-3-aminopropane on fungal polyamine metabolism were evaluated using… Expand
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2001
2001
Hydroxylamine-containing inhibitors of polyamine biosynthesis and impairment of colon cancer cell growth.
Polyamine synthesis (by the action of ornithine decarboxylase [ODC] and S-adenosylmethionine decarboxylase [SAMDC]) and polyamine… Expand
1997
1997
Polyamine‐dependent alterations in the structure of microfilaments, golgi apparatus, endoplasmic reticulum, and proteoglycan synthesis in BHK cells
The activity of ornithine decarboxylase, the key enzyme in the synthesis of polyamines, is essential for proliferation and… Expand
1994
1994
Derivatives of 1-aminooxy-3-aminopropane as polyamine antimetabolites: stability and effects on BHK21/C13 cells.
1- or 3-methylated derivatives and oximes of 1-aminooxy-3-aminopropane (APA) with pyridoxal (PL) and pyridoxal 5'-phosphate (PLP… Expand
Highly Cited
1992
Highly Cited
1992
Monitoring of the uptake and metabolism of aminooxy analogues of polyamines in cultured cells by high-performance liquid chromatography.
A high-performance liquid chromatographic method for the determination of polyamines and their aminooxy analogues is described… Expand
1991
1991
An early enlargement of the putrescine pool is required for growth in L1210 mouse leukemia cells under hypoosmotic stress.
Hypoosmotic stress is a potent inducer of ornithine decarboxylase (ODC) activity in a variety of mammalian cells, but the… Expand
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1990
1990
Uptake of 3H-labeled 1-aminooxy-3-aminopropane by baby hamster kidney cells.
The uptake, catabolism, and release of H-labeled 1-aminooxy-3-aminopropane, a new putrescine analog shown to be a potent… Expand
1986
1986
The effects of 1‐aminooxy‐3‐aminopropane and S‐(5'‐deoxy‐5'‐adenosyl)methylthioethylhydroxylamine on ornithine decarboxylase and S‐adenosyl‐L‐methionine decarboxylase from Escherichia coli
1‐Aminooxy‐3‐aminopropane (APA) was shown to be a potent competitive inhibitor (K i = 1.0 nM) of partially purified Escherichia… Expand
1985
1985
1-Aminooxy-3-aminopropane, a new and potent inhibitor of polyamine biosynthesis that inhibits ornithine decarboxylase, adenosylmethionine decarboxylase and spermidine synthase.
1-Aminooxy-3-aminopropane was shown to be a potent competitive inhibitor (Ki = 3.2 nM) of homogenous mouse kidney ornithine… Expand
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