1-aminooxy-3-aminopropane

Known as: 1-Propanamine, 3-(aminooxy)-, 3-aminooxy-1-propanamine 
 
National Institutes of Health

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2 relations

Broader (2)

Ornithine Decarboxylase InhibitorsPropylamines

Papers overview

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2003
2003
The putrescine analogue 1-aminooxy-3-aminopropane perturbs polyamine metabolism in the phytopathogenic fungus Sclerotinia sclerotiorum
AbstractThe effects of the putrescine analogue 1-aminooxy-3-aminopropane on fungal polyamine metabolism were evaluated using… Expand
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2001
2001
Hydroxylamine-containing inhibitors of polyamine biosynthesis and impairment of colon cancer cell growth.
Polyamine synthesis (by the action of ornithine decarboxylase [ODC] and S-adenosylmethionine decarboxylase [SAMDC]) and polyamine… Expand
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1997
1997
Polyamine-dependent alterations in the structure of microfilaments, Golgi apparatus, endoplasmic reticulum, and proteoglycan synthesis in BHK cells.
The activity of ornithine decarboxylase, the key enzyme in the synthesis of polyamines, is essential for proliferation and… Expand
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1994
1994
Derivatives of 1-aminooxy-3-aminopropane as polyamine antimetabolites: stability and effects on BHK21/C13 cells.
1- or 3-methylated derivatives and oximes of 1-aminooxy-3-aminopropane (APA) with pyridoxal (PL) and pyridoxal 5'-phosphate (PLP… Expand
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1993
1993
Pharmacological properties of the ornithine decarboxylase inhibitor 3-aminooxy-1-propanamine and several structural analogues
  • Helmut Mett, Jaroslav Stanek, +5 authors Urs Regenass
  • Cancer Chemotherapy and Pharmacology
  • 1993
Analogues of 3-aminooxy-1-propanamine proved to be highly potent and selective inhibitors of ornithine decarboxylase (ODC). The… Expand
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1991
1991
An early enlargement of the putrescine pool is required for growth in L1210 mouse leukemia cells under hypoosmotic stress.
Hypoosmotic stress is a potent inducer of ornithine decarboxylase (ODC) activity in a variety of mammalian cells, but the… Expand
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1990
1990
Uptake of 3H-labeled 1-aminooxy-3-aminopropane by baby hamster kidney cells.
The uptake, catabolism, and release of H-labeled 1-aminooxy-3-aminopropane, a new putrescine analog shown to be a potent… Expand
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1990
1990
Regulation of S-adenosyl-L-methionine decarboxylase by 1-aminooxy-3-aminopropane: enzyme kinetics and effects on the enzyme activity in cultured cells.
The kinetics of inactivation of adenosylmethionine decarboxylase of rat liver and of baby hamster kidney cells (BHK21/C31) by 1… Expand
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1986
1986
The effects of 1-aminooxy-3-aminopropane and S-(5'-deoxy-5'-adenosyl)methylthioethylhydroxylamine on ornithine decarboxylase and S-adenosyl-L-methionine decarboxylase from Escherichia coli.
1-Aminooxy-3-aminopropane (APA) was shown to be a potent competitive inhibitor (Ki = 1.0 nM) of partially purified Escherichia… Expand
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1985
1985
1-Aminooxy-3-aminopropane, a new and potent inhibitor of polyamine biosynthesis that inhibits ornithine decarboxylase, adenosylmethionine decarboxylase and spermidine synthase.
1-Aminooxy-3-aminopropane was shown to be a potent competitive inhibitor (Ki = 3.2 nM) of homogenous mouse kidney ornithine… Expand
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