Skip to search formSkip to main contentSkip to account menu

Eflornithine Hydrochloride

Known as: Eflornithine.HCl, Hydrochloride, Eflornithine, Eflornithine Monohydrochloride, Monohydrate 
The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits… 
National Institutes of Health

Related topics

Related topics

11 relations
African TrypanosomiasisAntiprotozoal AgentsDecarboxylase Inhibitors [MoA]Decreased Protein Synthesis [PE]

Broader (1)

Eflornithine

Narrower (1)

Vaniqa

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial
Highly Cited
2013
Highly Cited
2013
Nifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo.
BACKGROUND Existing diagnostic and treatment tools for human African trypanosomiasis (HAT) are limited. The recent development of… 
Review
2013
Review
2013
A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis
Abstract Despite the recent advances in drug research, finding a safe, effective, and easy to use chemotherapy for human African… 
Highly Cited
2011
Highly Cited
2011
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
Review
2011
Review
2011
Drug resistance in human African trypanosomiasis.
Human African trypanosomiasis or 'sleeping sickness' is a neglected tropical disease caused by the parasite Trypanosoma brucei. A… 
Highly Cited
2010
Highly Cited
2010
Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis
ABSTRACT The success of nifurtimox-eflornithine combination therapy (NECT) for the treatment of human African trypanosomiasis… 
Review
2010
Review
2010
Chemotherapy against human African trypanosomiasis: Is there a road to success?
  • C. Burri
  • Parasitology
  • 2010
  • Corpus ID: 38573878
SUMMARY For over fifty years, human African trypanosomiasis (HAT, sleeping sickness) has been treated with suramin, pentamidine… 
Highly Cited
2009
Highly Cited
2009
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial
Highly Cited
2007
Highly Cited
2007
Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo.
BACKGROUND Human African trypanosomiasis caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options for… 
Review
2003
Review
2003
The evaluation and management of hirsutism.
  • R. Azziz
  • Obstetrics and gynecology
  • 2003
  • Corpus ID: 1617103
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License