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Eflornithine Hydrochloride

Known as: Eflornithine.HCl, Hydrochloride, Eflornithine, Eflornithine Monohydrochloride, Monohydrate 
The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits… Expand
National Institutes of Health

Related topics

Related topics

11 relations
African TrypanosomiasisAntiprotozoal AgentsDecarboxylase Inhibitors [MoA]Decreased Protein Synthesis [PE]
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Broader (1)

Eflornithine

Narrower (1)

Vaniqa

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial
BACKGROUND Few therapeutic options are available to treat the late-stage of human African trypanosomiasis, a neglected tropical… Expand
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Highly Cited
2013
Highly Cited
2013
Nifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo.
BACKGROUND Existing diagnostic and treatment tools for human African trypanosomiasis (HAT) are limited. The recent development of… Expand
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Review
2013
Review
2013
A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis
Abstract Despite the recent advances in drug research, finding a safe, effective, and easy to use chemotherapy for human African… Expand
Highly Cited
2011
Highly Cited
2011
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
Graphical abstract Genome-scale RNA interference (RNAi) library screens in bloodstream-form Trypanosoma brucei, using nifurtimox… Expand
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Review
2011
Review
2011
Drug resistance in human African trypanosomiasis.
Human African trypanosomiasis or 'sleeping sickness' is a neglected tropical disease caused by the parasite Trypanosoma brucei. A… Expand
Highly Cited
2010
Highly Cited
2010
Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis
ABSTRACT The success of nifurtimox-eflornithine combination therapy (NECT) for the treatment of human African trypanosomiasis… Expand
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Review
2010
Review
2010
Chemotherapy against human African trypanosomiasis: Is there a road to success?
  • C. Burri
  • Parasitology
  • 2010
    • Corpus ID: 38573878
SUMMARY For over fifty years, human African trypanosomiasis (HAT, sleeping sickness) has been treated with suramin, pentamidine… Expand
Review
2010
Review
2010
NECT Is Next: Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness
Fatal if untreated, human African trypanosomiasis (HAT; sleeping sickness) afflicts an estimated 50,000–70,000 people each year… Expand
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Highly Cited
2009
Highly Cited
2009
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial
BACKGROUND Human African trypanosomiasis (HAT; sleeping sickness) caused by Trypanosoma brucei gambiense is a fatal disease… Expand
Highly Cited
2007
Highly Cited
2007
Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo.
BACKGROUND Human African trypanosomiasis caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options for… Expand
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