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Eflornithine Hydrochloride

Known as: Eflornithine.HCl, Hydrochloride, Eflornithine, Eflornithine Monohydrochloride, Monohydrate 
The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits… 
National Institutes of Health

Related topics

Related topics

11 relations
African TrypanosomiasisAntiprotozoal AgentsDecarboxylase Inhibitors [MoA]Decreased Protein Synthesis [PE]

Broader (1)

Eflornithine

Narrower (1)

Vaniqa

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Androgen excess: Investigations and management.
Highly Cited
2013
Highly Cited
2013
Nifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo.
BACKGROUND Existing diagnostic and treatment tools for human African trypanosomiasis (HAT) are limited. The recent development of… 
Highly Cited
2011
Highly Cited
2011
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
Highly Cited
2010
Highly Cited
2010
Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis
ABSTRACT The success of nifurtimox-eflornithine combination therapy (NECT) for the treatment of human African trypanosomiasis… 
Review
2010
Review
2010
NECT Is Next: Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness
Fatal if untreated, human African trypanosomiasis (HAT; sleeping sickness) afflicts an estimated 50,000–70,000 people each year… 
Highly Cited
2007
Highly Cited
2007
Randomized, double‐blind clinical evaluation of the efficacy and safety of topical eflornithine HCl 13.9% cream in the treatment of women with facial hair
Greater than 40% of women in the USA have unwanted facial hair. 1 The condition can have a profound impact on a woman’s self… 
Highly Cited
2006
Highly Cited
2006
Three Drug Combinations for Late-Stage Trypanosoma brucei gambiense Sleeping Sickness: A Randomized Clinical Trial in Uganda
Objectives: Our objective was to compare the efficacy and safety of three drug combinations for the treatment of late-stage human… 
Review
2003
Review
2003
The evaluation and management of hirsutism.
Review
2001
Review
2001
Topical Eflornithine
Abstract▴ Eflornithine is a specific, irreversible inhibitor of the enzyme ornithine decarboxylase which is thought to slow hair… 
Highly Cited
1992
Highly Cited
1992
Treatment of recurrent gliomas with eflornithine.
BACKGROUND Oral eflornithine in combination with intravenous mitoguazone (methylbisguanylhydrazone) has shown activity against… 
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