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Eflornithine Hydrochloride
Known as:
Eflornithine.HCl
, Hydrochloride, Eflornithine
, Eflornithine Monohydrochloride, Monohydrate
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The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits…
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National Institutes of Health
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Related topics
Related topics
11 relations
African Trypanosomiasis
Antiprotozoal Agents
Decarboxylase Inhibitors [MoA]
Decreased Protein Synthesis [PE]
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Broader (1)
Eflornithine
Narrower (1)
Vaniqa
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial
Victor Kande Betu Ku Mesu
,
Wilfried Mutombo Kalonji
,
+23 authors
A. Tarral
The Lancet
2018
Corpus ID: 46781585
Highly Cited
2013
Highly Cited
2013
Nifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo.
E. Alirol
,
D. Schrumpf
,
+4 authors
F. Chappuis
Clinical infectious diseases : an official…
2013
Corpus ID: 10123149
BACKGROUND Existing diagnostic and treatment tools for human African trypanosomiasis (HAT) are limited. The recent development of…
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Review
2013
Review
2013
A current analysis of chemotherapy strategies for the treatment of human African trypanosomiasis
Peter Babokhov
,
A. Sanyaolu
,
W. Oyibo
,
A. Fagbenro-Beyioku
,
N. Iriemenam
Pathogens and global health
2013
Corpus ID: 33241906
Abstract Despite the recent advances in drug research, finding a safe, effective, and easy to use chemotherapy for human African…
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Highly Cited
2011
Highly Cited
2011
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
N. Baker
,
S. Alsford
,
D. Horn
Molecular and biochemical parasitology
2011
Corpus ID: 12920974
Review
2011
Review
2011
Drug resistance in human African trypanosomiasis.
M. Barrett
,
Isabel M. Vincent
,
R. Burchmore
,
A. Kazibwe
,
E. Matovu
Future microbiology
2011
Corpus ID: 33974419
Human African trypanosomiasis or 'sleeping sickness' is a neglected tropical disease caused by the parasite Trypanosoma brucei. A…
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Highly Cited
2010
Highly Cited
2010
Cross-Resistance to Nitro Drugs and Implications for Treatment of Human African Trypanosomiasis
A. Y. Sokolova
,
S. Wyllie
,
S. Patterson
,
Sandra L. Oza
,
K. Read
,
A. Fairlamb
Antimicrobial Agents and Chemotherapy
2010
Corpus ID: 2708956
ABSTRACT The success of nifurtimox-eflornithine combination therapy (NECT) for the treatment of human African trypanosomiasis…
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Review
2010
Review
2010
Chemotherapy against human African trypanosomiasis: Is there a road to success?
C. Burri
Parasitology
2010
Corpus ID: 38573878
SUMMARY For over fifty years, human African trypanosomiasis (HAT, sleeping sickness) has been treated with suramin, pentamidine…
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Highly Cited
2009
Highly Cited
2009
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial
G. Priotto
,
S. Kasparian
,
+14 authors
V. Kande
The Lancet
2009
Corpus ID: 32757305
Highly Cited
2007
Highly Cited
2007
Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo.
G. Priotto
,
S. Kasparian
,
+4 authors
U. Karunakara
Clinical infectious diseases : an official…
2007
Corpus ID: 14849106
BACKGROUND Human African trypanosomiasis caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options for…
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Review
2003
Review
2003
The evaluation and management of hirsutism.
R. Azziz
Obstetrics and gynecology
2003
Corpus ID: 1617103
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