Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Eflornithine Hydrochloride

Known as: Eflornithine.HCl, Hydrochloride, Eflornithine, Eflornithine Monohydrochloride, Monohydrate 
The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits… Expand
National Institutes of Health

Related topics

Related topics

11 relations
African TrypanosomiasisAntiprotozoal AgentsDecarboxylase Inhibitors [MoA]Decreased Protein Synthesis [PE]
Expand

Broader (1)

Eflornithine

Narrower (1)

Vaniqa

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Oral fexinidazole for late-stage African Trypanosoma brucei gambiense trypanosomiasis: a pivotal multicentre, randomised, non-inferiority trial
BACKGROUND Few therapeutic options are available to treat the late-stage of human African trypanosomiasis, a neglected tropical… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • table 2
Is this relevant?
Highly Cited
2013
Highly Cited
2013
Nifurtimox-eflornithine combination therapy for second-stage gambiense human African trypanosomiasis: Médecins Sans Frontières experience in the Democratic Republic of the Congo.
BACKGROUND Existing diagnostic and treatment tools for human African trypanosomiasis (HAT) are limited. The recent development of… Expand
  • figure 1
  • table 1
  • table 2
  • table 3
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
Graphical abstract Genome-scale RNA interference (RNAi) library screens in bloodstream-form Trypanosoma brucei, using nifurtimox… Expand
  • figure 1
  • figure 2
Is this relevant?
Review
2011
Review
2011
Drug resistance in human African trypanosomiasis.
Human African trypanosomiasis or 'sleeping sickness' is a neglected tropical disease caused by the parasite Trypanosoma brucei. A… Expand
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.
The success of nifurtimox-eflornithine combination therapy (NECT) for the treatment of human African trypanosomiasis (HAT) has… Expand
  • figure 1
  • figure 4
  • figure 2
  • figure 3
  • figure 5
Is this relevant?
Review
2010
Review
2010
NECT Is Next: Implementing the New Drug Combination Therapy for Trypanosoma brucei gambiense Sleeping Sickness
Fatal if untreated, human African trypanosomiasis (HAT; sleeping sickness) afflicts an estimated 50,000–70,000 people each year… Expand
  • figure 1
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial
BACKGROUND Human African trypanosomiasis (HAT; sleeping sickness) caused by Trypanosoma brucei gambiense is a fatal disease… Expand
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo.
BACKGROUND Human African trypanosomiasis caused by Trypanosoma brucei gambiense is a fatal disease. Current treatment options for… Expand
  • figure 1
  • table 1
  • table 2
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Randomized, double-blind clinical evaluation of the efficacy and safety of topical eflornithine HCl 13.9% cream in the treatment of women with facial hair.
 
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Three Drug Combinations for Late-Stage Trypanosoma brucei gambiense Sleeping Sickness: A Randomized Clinical Trial in Uganda
Objectives: Our objective was to compare the efficacy and safety of three drug combinations for the treatment of late-stage human… Expand
  • figure 1
  • table 1
  • table 2
  • table 3
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE