Share This Author
Genome sequence of the human malaria parasite Plasmodium falciparum
The genome sequence of P. falciparum clone 3D7 is reported, which is the most (A + T)-rich genome sequenced to date and is being exploited in the search for new drugs and vaccines to fight malaria.
The Genome of the African Trypanosome Trypanosoma brucei
Comparisons of the cytoskeleton and endocytic trafficking systems of Trypanosoma brucei with those of humans and other eukaryotic organisms reveal major differences.
Drug Resistance in Leishmaniasis
It is essential that there be a strategy to prevent the emergence of resistance to new drugs; combination therapy, monitoring of therapy, and improved diagnostics could play an essential role in this strategy.
Arsenical-resistant trypanosomes lack an unusual adenosine transporter
It is reported that the in vitro trypanolytic effect of melarsen oxide can be specifically abrogated by adenine, adenosine and dipyridamole, all of which compete for uptake by anadenosine transporter.
Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells
The findings suggest that the unusual potency of T. gondii in inducing IL-12 from DCs results from its synthesis of a unique chemokine mimic that signals through CCR5, which may benefit parasite transmission by preventing the protozoan from overwhelming its intermediate hosts.
Chemotherapy of human African trypanosomiasis: current and future prospects.
- A. Fairlamb
- MedicineTrends in parasitology
- 1 November 2003
Metabolism and functions of trypanothione in the Kinetoplastida.
The purification and properties of three key enzymes (glutathionylspermidine synthetases, trypanothione synthetase, and trypanothsione reductase) are discussed, and the catalytic mechanism, substrate-specificity, andThe three-dimensional structure of trypanOTHione reduCTase are compared to that of glutathione reductor.
Kinetoplastids: related protozoan pathogens, different diseases.
Kinetoplastids are a group of flagellated protozoans that include the species Trypanosoma and Leishmania, which are human pathogens with devastating health and economic effects. The sequencing of the…
Dual Action of Antimonial Drugs on Thiol Redox Metabolism in the Human Pathogen Leishmania donovani*
It is shown that trivalent antimony (SbIII) interferes with trypanothione metabolism in drug-sensitive Leishmania parasites by two inherently distinct mechanisms, which combine to profoundly compromise the thiol redox potential in both amastigote and promastigotes stages of the life cycle.
Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids.
The cofactor was purified from the insect trypanosomatid Crithidia fasciculata and identified as a novel glutathione-sperMidine conjugate, N1,N8-bis(L-gamma-glutamyl-L-hemicystinyl-glycyl)spermidine, for which the trivial name trypanothione is proposed.