EPHX1 gene

Known as: EPOXIDE HYDROLASE 1, MICROSOMAL, EPOXIDE HYDROLASE, MEH 
This gene is involved in both the activation and detoxification of xenobiotics.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Soluble epoxide hydrolase (sEH) is an enzyme involved in the metabolism of endogenous inflammatory and antiapoptotic mediators… (More)
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Highly Cited
2007
Highly Cited
2007
Arachidonic acid-derived epoxides, epoxyeicosatrienoic acids, are important regulators of vascular homeostasis and inflammation… (More)
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2006
2006
We investigated the roles of EPHX1 Tyr113His and His139Arg polymorphisms in lung cancer susceptibility in a Finnish study… (More)
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Highly Cited
2006
Highly Cited
2006
Endothelial dysfunction contributes to the development of coronary heart disease (CHD). Soluble epoxide hydrolase metabolizes… (More)
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2006
2006
Single nucleotide polymorphisms (SNPs) in the human EPHX2 gene have recently been implicated in susceptibility to cardiovascular… (More)
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Highly Cited
2005
Highly Cited
2005
We previously reported that laminar flow activates peroxisome proliferator-activated receptor gamma (PPARgamma) in vascular… (More)
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Highly Cited
2005
Highly Cited
2005
Soluble epoxide hydrolase (sEH) inhibitors have been demonstrated to have cardiovascular protective actions. This hydrolase… (More)
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Highly Cited
2003
Highly Cited
2003
Human soluble epoxide hydrolase (hsEH) metabolizes a variety of epoxides to the corresponding vicinal diols. Arachidonic and… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND The first-pass metabolism of foreign compounds in the lung is an important protective mechanism against oxidative… (More)
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Highly Cited
1993
Highly Cited
1993
We report the cloning and expression of a cDNA that encodes a soluble epoxide hydrolase from human liver. The 2101-base clone… (More)
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