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Signals from the stressed endoplasmic reticulum induce C/EBP-homologous protein (CHOP/GADD153).
The gene encoding C/EBP-homologous protein (CHOP), also known as growth arrest and DNA-damage-inducible gene 153 (GADD153), is activated by agents that adversely affect the function of theExpand
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A molecular map of the chicken major histocompatibility complex: the class II beta genes are closely linked to the class I genes and the nucleolar organizer.
We have cloned in a cosmid vector four DNA clusters covering 320 kb of the chicken MHC (B complex), including five class II (B‐L) beta genes defining two related isotypic families. Additional BExpand
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Synthesis and incorporation of myelin polypeptides into CNS myelin
The distribution of newly synthesized proteolipid protein (PLP, 23 kdaltons) and myelin basic proteins (MBPs, 14-21.5 kdaltons) was determined in microsomal and myelin fractions prepared from theExpand
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Uroplakins in urothelial biology, function, and disease.
Urothelium covers the inner surfaces of the renal pelvis, ureter, bladder, and prostatic urethra. Although morphologically similar, the urothelia in these anatomic locations differ in their embryonicExpand
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Oligosaccharyltransferase activity is associated with a protein complex composed of ribophorins I and II and a 48 kd protein
Oligosaccharyltransferase catalyzes the N-linked glycosylation of asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum (RER). A protein complex composed of 66,Expand
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The bladder as a bioreactor: Urothelium production and secretion of growth hormone into urine
Uroplakin genes are expressed in a bladder-specific and differentiation-dependent fashion. Using a 3.6-kb promoter of mouse uroplakin II gene, we have generated transgenic mice that express humanExpand
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Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex
In eukaryotic cells, polypeptides are N glycosylated after passing through the membrane of the ER into the ER lumen. This modification is effected cotranslationally by the multimericExpand
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Ribosomal-membrane interaction: in vitro binding of ribosomes to microsomal membranes.
Rat liver rough microsomal membranes were stripped of bound ribosomes by treatment with puromycin and high concentrations of monovalent ions. Ribosomal subunits labeled in the RNA were detached fromExpand
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Specific heterodimer formation is a prerequisite for uroplakins to exit from the endoplasmic reticulum.
Much of the lower urinary tract, including the bladder, is lined by a stratified urothelium forming a highly differentiated, superficial umbrella cell layer. The apical plasma membrane as well asExpand
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Nascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum.
We show that, after removal of the nascent polypeptide-associated complex (NAC) from ribosome-associated nascent chains, ribosomes synthesizing proteins lacking signal peptides are efficientlyExpand
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