Microsomal Epoxide Hydrolase

Known as: Epoxide Hydroxylase 1, Microsomal (Xenobiotic), EC 3.3.2.9, Epoxide Hydroxylase 1, Microsomal 
Epoxide hydrolase 1 (455 aa, ~53 kDa) is encoded by the human EPHX1 gene. This protein is involved in the hydrolysis of cyclic organic compounds.
National Institutes of Health

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EPHX1 geneEPHX1 wt AlleleEnzyme GeneHomo sapiens
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Epoxide hydrolase

Papers overview

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2010
2010
Microsomal epoxide hydrolase polymorphisms.
Microsomal epoxide hydrolase plays a dual role in the activation and detoxification of carcinogenic compounds. Two polymorphic… (More)
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Review
2009
Review
2009
Mammalian epoxide hydrolases in xenobiotic metabolism and signalling
Epoxide hydrolases catalyse the hydrolysis of electrophilic—and therefore potentially genotoxic—epoxides to the corresponding… (More)
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2003
2003
Association of microsomal epoxide hydrolase polymorphisms and lung cancer risk
Microsomal epoxide hydrolase (mEH) plays a dual role in the detoxification and activation of tobacco procarcinogens. Two… (More)
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Highly Cited
1999
Highly Cited
1999
Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene.
Microsomal epoxide hydrolase (mEH) is a conserved enzyme that is known to hydrolyze many drugs and carcinogens, and a few… (More)
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Highly Cited
1998
Highly Cited
1998
Association between lung cancer and microsomal epoxide hydrolase genotypes.
Microsomal epoxide hydrolase (mEH) is involved in the metabolism of tobacco-derived carcinogens. Polymorphisms in exons 3 and 4… (More)
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1998
1998
Human microsomal epoxide hydrolase: 5'-flanking region genetic polymorphisms.
Microsomal epoxide hydrolase (mEH) catalyses the hydrolysis of xenobiotic epoxides, including various epoxide derivatives of the… (More)
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Highly Cited
1997
Highly Cited
1997
Association between polymorphism in gene for microsomal epoxide hydrolase and susceptibility to emphysema
BACKGROUND The first-pass metabolism of foreign compounds in the lung is an important protective mechanism against oxidative… (More)
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Highly Cited
1997
Highly Cited
1997
Human hepatic microsomal epoxide hydrolase: comparative analysis of polymorphic expression.
Interindividual variation in the expression of human microsomal epoxide hydrolase (mEH) may be an important risk factor for… (More)
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Highly Cited
1996
Highly Cited
1996
Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of…
Foreign compound-metabolizing enzymes may modify the risk of chemically induced cancer. We wanted to examine enzymes with… (More)
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Highly Cited
1994
Highly Cited
1994
Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants.
Human microsomal epoxide hydrolase (mEH) is a biotransformation enzyme that metabolizes reactive epoxide intermediates to more… (More)
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