Simultaneous Humoral and Cellular Immune Response against Cancer–Testis Antigen NY-ESO-1: Definition of Human Histocompatibility Leukocyte Antigen (HLA)-A2–binding Peptide Epitopes
- E. Jäger, Yao-Tseng Chen, A. Knuth
- Biology, MedicineJournal of Experimental Medicine
- 19 January 1998
It is shown that antigen-specific humoral and cellular immune responses against human tumor antigens may occur simultaneously in a single patient and a general strategy is provided for identifying the CTL-recognizing peptides of tumor antIGens initially defined by autologous antibody.
A Survey of the Humoral Immune Response of Cancer Patients to a Panel of Human Tumor Antigens
- E. Stockert, E. Jäger, L. Old
- Medicine, BiologyJournal of Experimental Medicine
- 20 April 1998
To establish a screening system for the humoral response to autoimmunogenic tumor antigens, an enzyme-linked immunosorbent assay (ELISA) was developed using recombinant NY-ESO-1, MAGE-3, SSX2, Melan-A, and tyrosinase proteins.
A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms.
- M. Arand, R. Mühlbauer, F. Oesch
- BiologyAnalytical Biochemistry
- 5 April 1996
Mammalian epoxide hydrolases in xenobiotic metabolism and signalling
- Martina Decker, M. Arand, A. Cronin
- BiologyArchives of Toxicology
- 2 April 2009
Takeaway is that epoxide hydrolases play a central role in the detoxification of genotoxic epoxides and have an important function in the regulation of physiological processes by the control of signalling molecules with an epoxide structure.
Aryl hydrocarbon receptor activation by cAMP vs. dioxin: divergent signaling pathways.
- B. Oesch-Bartlomowicz, A. Huelster, F. Oesch
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 28 June 2005
It is shown that the second messenger, cAMP (an endogenous mediator of hormones, neurotransmitters, and prostaglandins), activates the AHR, moving the receptor to the nucleus in some ways that are similar to and in other ways fundamentally different from AHR activation by dioxin.
The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase
- A. Cronin, S. Mowbray, M. Arand
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 6 February 2003
The mammalian soluble epoxide hydrolase (sEH) is an enzyme with multiple functions, being implicated in detoxification of xenobiotic epoxides as well as in regulation of physiological processes such as blood pressure, and a putative active site containing all necessary components for phosphatase activity is identified.
Pharmacogenetics of Modafinil After Sleep Loss: Catechol‐O‐Methyltransferase Genotype Modulates Waking Functions But Not Recovery Sleep
- S. Bodenmann, S. Xu, HP Landolt
- Biology, PsychologyClinical pharmacology and therapy
- 1 March 2009
Dopaminergic mechanisms contribute to impaired waking functions after sleep loss and neither modafinil nor the Val158Met polymorphism affected distinct markers of sleep homeostasis in recovery sleep.
Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism
- A. Marowsky, J. Burgener, J. Falck, J. Fritschy, M. Arand
- BiologyNeuroscience
- 6 October 2009
Tonic Inhibition in Principal Cells of the Amygdala: A Central Role for α3 Subunit-Containing GABAA Receptors
- A. Marowsky, U. Rudolph, J. Fritschy, M. Arand
- BiologyJournal of Neuroscience
- 20 June 2012
It is demonstrated that α3 GABAAR-mediated tonic inhibition is a central component of the inhibitory force in the amygdala and that tonically activated α3 GABAARs present an important target for anxiolytic or fear-reducing compounds.
Granulocyte‐macrophage‐colony‐stimulating factor enhances immune responses to melanoma‐associated peptides in vivo
- E. Jäger, M. Ringhoffer, A. Knuth
- BiologyInternational Journal of Cancer
- 3 July 1996
It is concluded that systemic GM‐CSF enhances immune responses to melanoma‐associated peptides and supports CTL‐mediated tumor rejection in vivo.
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