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Mass spectrometry-based metabolomics.
This review presents an overview of the dynamically developing field of mass spectrometry-based metabolomics, a technique that analyzes all detectable analytes in a given sample with subsequent classification of samples and identification of differentially expressed metabolites, which define the sample classes.
The antiinflammatory effect of laminar flow: the role of PPARgamma, epoxyeicosatrienoic acids, and soluble epoxide hydrolase.
- Yi Liu, Yingjia Zhang, J. Shyy
- BiologyProceedings of the National Academy of Sciences…
- 15 November 2005
Whether epoxyeicosatrienoic acids (EETs), the catalytic products of cytochrome P450 epoxygenases, are PPARgamma ligands is investigated and competition and direct binding assays revealed that EETs bind to the ligand-binding domain of PPargamma with K(d) in the microM range.
Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases
The cardiovascular effects of epoxyeicosatrienoic acids (EETs) include vasodilation, antimigratory actions on vascular smooth muscle cells and anti-inflammatory actions, and inhibiting this enzyme would be expected to enhance the beneficial cardiovascular properties of EETs.
Applications of carboxylesterase activity in environmental monitoring and toxicity identification evaluations (TIEs).
- C. Wheelock, B. Phillips, B. Anderson, Jeffrey L. Miller, Mike J Miller, B. Hammock
- BiologyReviews of environmental contamination and…
The use of carboxylesterase activity in TIE protocols appears to have excellent promise, but there are further technical issues that should be addressed to increase the utility of the method.
Modulation of the Ca2 Permeable Cation Channel TRPV4 by Cytochrome P450 Epoxygenases in Vascular Endothelium
It is established that CYP-derived EETs modulate the activity of TRPV4 channels in endothelial cells and shows the unraveling of novel modulatory pathways via CYP2C modulation and sEH inhibition.
Epoxide hydrolases: mechanisms, inhibitor designs, and biological roles.
A review of the current understanding of the catalytic mechanism of the epoxide hydrolases suggests that the EHs as a family represent novel drug discovery targets for regulation of blood pressure, inflammation, cancer progression, and the onset of several other diseases.
Epoxide hydrolases: their roles and interactions with lipid metabolism.
Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K+ Channels and p42/p44 MAPK Pathway
Together, these data suggest that CYP2J2-derived metabolites are cardioprotective after ischemia, and the mechanism for thisCardioprotection involves activation of mitoKATP and p42/p44 MAPK.
Impact of soluble epoxide hydrolase and epoxyeicosanoids on human health.
How the pharmacological stabilization of EETs and other natural epoxy-fatty acids could lead to possible disease therapies is discussed.
In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens
Carbanilides, including TCC, enhanced hormone-dependent induction of ER- and AR-dependent gene expression but had little agonist activity, suggesting a new mechanism of action of endocrine-disrupting compounds.