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ELANE wt Allele

Known as: HLE, PMN-E, SCN1 
Human ELANE wild-type allele is located in the vicinity of 19p13.3 and is approximately 4 kb in length. This allele, which encodes neutrophil… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (1)

ELANE gene
HydrolysisProteolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal.
Reactive intermediates produced during oxidative stress are believed to contribute to the development and progression of a… 
Highly Cited
2003
Highly Cited
2003
Cells Preconditioned with Mild, Transient UVA Irradiation Acquire Resistance to Oxidative Stress and UVA-induced Apoptosis
Because 4-hydroxynonenal (4-HNE) has been suggested to be involved in oxidative stress-mediated apoptosis (Cheng, J. Z., Sharma… 
Review
2003
Review
2003
4-hydroxynonenal triggers multistep signal transduction cascades for suppression of cellular functions.
Highly Cited
2002
Highly Cited
2002
High Molecular Weight Neurofilament Proteins Are Physiological Substrates of Adduction by the Lipid Peroxidation Product Hydroxynonenal*
Protein adducts of the lipid peroxidation producttrans-4-hydroxy-2-nonenal (HNE) are features of oxidative damage in neuronal… 
Highly Cited
2002
Highly Cited
2002
Protection against acute lung injury by intravenous or intratracheal pretreatment with EPI-HNE-4, a new potent neutrophil elastase inhibitor.
Excessive accumulation of active neutrophil elastase (NE) in pulmonary fluids and tissues of patients with cystic fibrosis (CF… 
Highly Cited
2000
Highly Cited
2000
Serum 4-hydroxy-2-nonenal-modified albumin is elevated in patients with type 2 diabetes mellitus.
4-Hydroxy-2-nonenal (HNE) is one of the major lipid peroxidation products with cytotoxic and mutagenic activity. It further… 
Highly Cited
1997
Highly Cited
1997
High dietary omega-6 polyunsaturated fatty acids drastically increase the formation of etheno-DNA base adducts in white blood cells of female subjects.
Lipid peroxidation generates reactive aldehydes such as trans-4-hydroxy-2-nonenal and malonaldehyde, which form promutagenic… 
Highly Cited
1997
Highly Cited
1997
Cellular response to the redox active lipid peroxidation products: induction of glutathione S-transferase P by 4-hydroxy-2-nonenal.
Membrane lipid peroxidation is known to produce various aldehydic compounds which cause a wide range of biological effects… 
Highly Cited
1991
Highly Cited
1991
Induction of differentiation in human HL-60 cells by 4-hydroxynonenal, a product of lipid peroxidation.
Highly Cited
1985
Highly Cited
1985
Effects of 4-hydroxynonenal on adenylate cyclase and 5'-nucleotidase activities in rat liver plasma membranes.
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