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Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.
There were no main effects of the SNPs on PTSD symptoms and no significant genetic interactions with level of non-child abuse trauma as predictor of adult PTSD symptoms, suggesting a potential gene-childhood environment interaction for adult PTSD. Expand
Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene.
Data support the corticotropin-releasing hormone hypothesis of depression and suggest that a gene x environment interaction is important for the expression of depressive symptoms in adults with CRHR1 risk or protective alleles who have a history of child abuse. Expand
Randomized, Double-Blind, Placebo-Controlled Phase III Trial of Apatinib in Patients With Chemotherapy-Refractory Advanced or Metastatic Adenocarcinoma of the Stomach or Gastroesophageal Junction.
  • Jin Li, S. Qin, +31 authors Hao Yu
  • Medicine
  • Journal of clinical oncology : official journal…
  • 27 September 2016
These data show that apatinib treatment significantly improved OS and PFS with an acceptable safety profile in patients with advanced gastric cancer refractory to two or more lines of prior chemotherapy. Expand
Structure of the Angiotensin Receptor Revealed by Serial Femtosecond Crystallography
The recently developed method of serial femtosecond crystallography at an X-ray free-electron laser determined the room-temperature crystal structure of the human AT(1)R in complex with its selective antagonist ZD7155 at 2.9-Å resolution, and revealed key structural features of AT( 1)R and critical interactions for ZD 7155 binding. Expand
Chronic effects of perfluorooctanesulfonate exposure on immunotoxicity in adult male C57BL/6 mice
The results indicate that PFOS exposure can affect the immunity function in mice at levels approximately 50-fold for highly exposed human populations. Expand
Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response.
Data indicate that a genetic variant within the CRHBP locus affects response to citalopram in African American and Hispanic patients, suggesting a role for this gene and for the CRF system in antidepressant treatment response. Expand
The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids.
It is proposed that the small intestine shields the liver from otherwise toxic fructose exposure, finding that dietary fructose is cleared by theSmall intestine, both by prior exposure to fructose and by feeding. Expand
Pollution and skin: from epidemiological and mechanistic studies to clinical implications.
The existing scientific evidence that air pollution exerts detrimental effects on human skin is summarized, potential clinical implications are discussed and specific and unspecific cosmetic protective measures are suggested. Expand
Buyang Huanwu Decoction can improve recovery of neurological function, reduce infarction volume, stimulate neural proliferation and modulate VEGF and Flk1 expressions in transient focal cerebral
The results indicate that the therapeutic effects of Buyang Huanwu Decoction for recovery of neurological deficits are associated with the stimulation of the proliferation of progenitors and the enhancement of the expressions of VEGF and Flk in ischaemic brains. Expand
Optimal regimen of trastuzumab in combination with oxaliplatin/ capecitabine in first-line treatment of HER2-positive advanced gastric cancer (CGOG1001): a multicenter, phase II trial
The addition of trastuzumab to oxaliplatin/capecitabine was well tolerated and the results demonstrated encouraging efficacy. Expand