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E6 protein, Human papillomavirus type 16

Known as: 16E6 protein, HPV, oncogene protein E6, Human papillomavirus type 16, Protein E6, Human Papillomavirus Type 16 
Protein E6 (158 aa, ~19 kDa) is encoded by the human papillomavirus type 16 E6 gene. This protein is involved in both transcriptional activation and… 
National Institutes of Health

Related topics

Related topics

9 relations
E6 protein, Human papillomavirus type 18Genes, ViralNeoplastic Cell TransformationOncogenes

Broader (3)

Human PapillomavirusOncogene Proteins, ViralRepressor Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
The Human Papillomavirus Type 16 E6 Oncoprotein Activates mTORC1 Signaling and Increases Protein Synthesis
ABSTRACT The mammalian target of rapamycin (mTOR) kinase acts as a cellular rheostat that integrates signals from a variety of… 
Highly Cited
2008
Highly Cited
2008
Regulation of singlet oxygen generation using single-walled carbon nanotubes.
We have designed a novel photodynamic therapy (PDT) agent using protein binding aptamer, photosensitizer, and single-walled… 
Highly Cited
2001
Highly Cited
2001
Papillomavirus Type 16 Oncogenes Downregulate Expression of Interferon-Responsive Genes and Upregulate Proliferation-Associated and NF-κB-Responsive Genes in Cervical Keratinocytes
ABSTRACT Infection with high-risk human papillomaviruses (HPV) is a major risk factor for development of cervical cancer… 
Highly Cited
2001
Highly Cited
2001
E Box-Dependent Activation of Telomerase by Human Papillomavirus Type 16 E6 Does Not Require Induction of c-myc
ABSTRACT Human papillomavirus type 16 (HPV-16) E6 activates telomerase specifically in epithelial cells. The oncogene c-myc has… 
Highly Cited
1992
Highly Cited
1992
The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells
Previous studies have shown that the E7 gene of human papillomavirus (HPV) type 16 or 18 alone was sufficient for immortalization… 
Highly Cited
1992
Highly Cited
1992
Interaction of the human papillomavirus type 16 E6 oncoprotein with wild-type and mutant human p53 proteins
The E6 oncoproteins encoded by the cancer-associated human papillomaviruses (HPVs) can associate with and promote the degradation… 
Highly Cited
1992
Highly Cited
1992
Transcriptional activation of several heterologous promoters by the E6 protein of human papillomavirus type 16
The E6 protein of human papillomavirus type 16 (HPV-16), along with E7, is responsible for the HPV-induced malignant… 
Highly Cited
1992
Highly Cited
1992
Antibodies to HPV-16 E6 and E7 proteins as markers for HPV-16-associated invasive cervical cancer.
Highly Cited
1991
Highly Cited
1991
The full-length E6 protein of human papillomavirus type 16 has transforming and trans-activating activities and cooperates with E7 to immortalize keratinocytes in culture
The wild-type E6 and E7 genes of human papillomavirus type 16 (HPV16) can cooperate to immortalize normal human keratinocytes in… 
Highly Cited
1987
Highly Cited
1987
Identification of the HPV‐16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines.
Human cervical carcinoma cell lines that harbor human papillomavirus (HPV) have been reported to retain selectively and express… 
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