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Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma
TLDR
The number of these particle-associated proteins is consistent with the expected proteins of a retrovirus, but the sizes of some are distinct from those of most known retroviruses of the primate subgroups. Expand
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.
TLDR
EGFR TK domain mutations are the first molecular change known to occur specifically in never smokers, and can lead to lung cancer pathogenesis. Expand
Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.
TLDR
The clonogenic assay was more sensitive when continuous drug exposures were utilized, although this was primarily related to the increased drug exposure time, and therefore it offers a valid, simple method of assessing chemosensitivity in established cell lines. Expand
High-throughput oncogene mutation profiling in human cancer
TLDR
High-throughput genotyping is adapted to query 238 known oncogene mutations across 1,000 human tumor samples and established robust mutation distributions spanning 17 cancer types, offering a new dimension in tumor genetics, where mutations involving multiple cancer genes may be interrogated simultaneously and in 'real time'. Expand
Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression.
TLDR
RASSF1A is a potential tumor suppressor gene that undergoes epigenetic inactivation in lung and breast cancers through hypermethylation of its promoter region and is associated with impaired patient survival. Expand
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
TLDR
Exome, transcriptome and copy-number alteration data are obtained from approximately 53 samples consisting of 36 primary human SCLC and normal tissue pairs and 17 matched SCLCs and lymphoblastoid cell lines to identify several potential targets for therapeutic intervention. Expand
Molecular Profiling of Breast Cancer Cell Lines Defines Relevant Tumor Models and Provides a Resource for Cancer Gene Discovery
TLDR
Overall, breast cancer cell lines were genetically more complex than tumors, but retained expression patterns with relevance to the luminal-basal subtype distinction. Expand
SOX2 Is an Amplified Lineage Survival Oncogene in Lung and Esophageal Squamous Cell Carcinomas
TLDR
A peak of genomic amplification on chromosome 3q26.33 found in squamous cell carcinomas of the lung and esophagus contains the transcription factor gene SOX2, which is necessary for normal esophageal squamous development, promotes differentiation and proliferation of basal tracheal cells and cooperates in induction of pluripotent stem cells. Expand
BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
TLDR
BAP1 is a nuclear-localized, ubiquitin carboxy-terminal hydrolase, suggesting that deubiquitinating enzymes may play a role in BRCA1 function, and may be a new tumor suppressor gene which functions in the B RCA1 growth control pathway. Expand
An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance
TLDR
A robust EMT signature is developed that predicts resistance to EGFR and PI3K/Akt inhibitors, highlights different patterns of drug responsiveness for epithelial and mesenchymal cells, and identifies Axl as a potential therapeutic target for overcoming EGFR inhibitor resistance associated with the mesenchyal phenotype. Expand
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