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Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic.
TLDR
Results indicate that L1 protein has the intrinsic capacity to assemble into empty capsid-like structures whose immunogenicity is similar to infectious virions. Expand
Efficient Intracellular Assembly of Papillomaviral Vectors
TLDR
The results suggest that the intracellular assembly of papillomavirus structural proteins around heterologous reporter plasmids is surprisingly promiscuous and may be driven primarily by a size discrimination mechanism. Expand
Carrageenan Is a Potent Inhibitor of Papillomavirus Infection
TLDR
Comparison of a variety of compounds revealed that carrageenan, a type of sulfated polysaccharide extracted from red algae, is an extremely potent infection inhibitor for a broad range of sexually transmitted HPVs. Expand
Cleavage of the papillomavirus minor capsid protein, L2, at a furin consensus site is necessary for infection
TLDR
It is shown that this step depends on the site-specific enzymatic cleavage of the PV minor virion protein L2 at a consensus furin recognition site and is potentially a target for PV inhibition. Expand
Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles
TLDR
The ability to generate preparative amounts of HPV16 L1 and L1-L2 VLP may have implications for the development of a serological assay to detect anti-HPV16 virion immune responses to conformational epitopes and for immunoprophylaxis against HPV16 infection. Expand
A review of clinical trials of human papillomavirus prophylactic vaccines.
TLDR
End of study analyses of the phase III trials of prophylactic human papillomavirus (HPV) virus-like particle (VLP) vaccines in young women strongly support the potential of the vaccines as high value public health interventions and justify their widespread implementation to prevent anogenital HPV infections and their associated neoplasia. Expand
Reactivity of human sera in a sensitive, high-throughput pseudovirus-based papillomavirus neutralization assay for HPV16 and HPV18.
TLDR
The SEAP pseudovirus-based neutralization assay should be a practical method for quantifying potentially protective antibody responses in HPV natural history and prophylactic vaccine studies. Expand
Genital transmission of HPV in a mouse model is potentiated by nonoxynol-9 and inhibited by carrageenan
TLDR
Development of a mouse model of cervicovaginal infection with HPV16 that recapitulates the establishment phase of papillomavirus infection is reported, and carrageenan, a polysaccharide present in some vaginal lubricants, prevented infection even in the presence of N-9, suggesting that carrageinan might serve as an effective topical HPV microbicide. Expand
Papillomavirus-Like Particles Induce Acute Activation of Dendritic Cells1
TLDR
It is found that murine bone marrow-derived dendritic cells (BMDCs) effectively bound and rapidly internalized bovine papillomavirus VLPs and play a central role in VLP-induced immunity. Expand
Maturation of Papillomavirus Capsids
TLDR
It is shown that papillomavirus capsids produced using this system undergo a maturation process in which the formation of inter-L1 disulfide bonds drives condensation and stabilization of the capsid. Expand
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