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Disulfiram
Known as:
Disulfiram [Chemical/Ingredient]
, TTD
, Disulfide, Tetraethylthiuram
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A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol…
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National Institutes of Health
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Related topics
Related topics
42 relations
Acetaldehyde
Alcoholic Intoxication, Chronic
Amprenavir
Clavulanate
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Broader (4)
Alcohol Deterrents
Emetics
Thiocarbamates
diethylthiocarbamate
Narrower (11)
Alcophobin
Antabus
Antabuse
Anticol
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1983
1983
Mechanism of inactivation of sheep liver cytoplasmic aldehyde dehydrogenase by disulfiram.
T. Kitson
Biochemical Journal
1983
Corpus ID: 28912051
Stoicheiometric amounts of [14C]disulfiram react rapidly with sheep liver cytoplasmic aldehyde dehydrogenase to give loss of…
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1982
1982
Cutaneous reactions to lower aliphatic alcohols before and during disulfiram therapy.
N. Haddock
,
J. Wilkin
Archives of Dermatology
1982
Corpus ID: 30245793
Cutaneous reactions to ethyl alcohol (ethanol), N-propyl alcohol (1-propanol), isopropyl alcohol (2-propanol), and acetaldehyde…
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Highly Cited
1981
Highly Cited
1981
Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine.
T. Ying
,
D. Sarma
,
E. Farber
Cancer Research
1981
Corpus ID: 12044214
Experiments were performed to assess the role of liver cell necrosis in the induction of early steps in liver carcinogenesis with…
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Highly Cited
1977
Highly Cited
1977
Reevaluation of the disulfiram-alcohol reaction in man.
A. Sauter
,
D. Boss
,
J. von Wartburg
Journal of Studies on Alcohol
1977
Corpus ID: 27103941
The intensity of the disulfiram-alcohol reaction is found to depend on the blood acetaldehyde level, a disulfiram-induced…
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1977
1977
Increased sympathetic nervous system activity in alcoholic patients treated with disulfiram.
C. Lake
,
L. Major
,
M. Ziegler
,
I. Kopin
American Journal of Psychiatry
1977
Corpus ID: 38872203
The authors measured plasma levels of norepinephrine (NE) and dopamine beta-hydroxylase (DBH), pulse rates, and blood pressures…
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1977
1977
Cerebrospinal fluid homovanillic acid in male alcoholics: effects of disulfiram.
L. Major
,
J. Ballenger
,
F. Goodwin
,
G. Brown
Biological Psychiatry
1977
Corpus ID: 38638033
It is well know that if an individual maintained on disulfiram (Antabuse) ingests alcohol, excess acetaldehyde is formed…
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1974
1974
Disulfiram hypersensitivity hepatitis.
E. Keeffe
,
F. Smith
Journal of the American Medical Association (JAMA…
1974
Corpus ID: 896315
DISULFIRAM is widely used as adjunctive therapy in the outpatient treatment of chronic alcoholism. Except for the disulfiram…
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Highly Cited
1971
Highly Cited
1971
CORRELATES OF OUTCOME IN DISULFIRAM TREATMENT OF ALCOHOLISM
F. Baekeland
,
L. Lundwall
,
B. Kissin
Journal of Nervous and Mental Disease
1971
Corpus ID: 26335913
Three groups of outpatient alcoholics treated with disulfiram (group 1: high abstinence clinic attenders; group 2: low abstinence…
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1967
1967
The crystal and molecular structure of tetraethylthiuram disulfide, C10N2H20S4.
I. Karle
,
J. A. Estlin
,
K. Britts
Acta crystallographica
1967
Corpus ID: 45222027
1953
1953
An evaluation of the use of tetraethylthiuram disulfide in the treatment of 560 cases of alcohol addiction.
E. Hoff
,
C. McKeown
American Journal of Psychiatry
1953
Corpus ID: 42374449
Since the discoverv that tetraethvlthiurarn METHOD OF STUDY disulfide (TETD) (s a potent a&-alcohol drug, it has been used by…
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