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Disulfiram

Known as: Disulfiram [Chemical/Ingredient], TTD, Disulfide, Tetraethylthiuram 
A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol… Expand
National Institutes of Health

Related topics

Related topics

42 relations
AcetaldehydeAlcoholic Intoxication, ChronicAmprenavirClavulanate
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Broader (4)

Alcohol DeterrentsEmeticsThiocarbamatesdiethylthiocarbamate

Narrower (11)

AlcophobinAntabusAntabuseAnticol
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Papers overview

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Highly Cited
2013
Highly Cited
2013
Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram.
The combination of a chemotherapeutic drug with a multidrug resistance (MDR) modulator has emerged as a promising strategy for… Expand
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Highly Cited
2006
Highly Cited
2006
Inhibitors of NF-κB signaling: 785 and counting
Nuclear factor kappa B (NF-κB) transcription factors regulate several important physiological processes, including inflammation… Expand
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Highly Cited
2004
Highly Cited
2004
Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial.
CONTEXT Disulfiram has emerged as a promising treatment for cocaine dependence, but it has not yet been evaluated in general… Expand
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Review
2003
Review
2003
DNA repair-deficient diseases, xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy.
Xeroderma pigmentosum (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD) are genetic disorders with very different… Expand
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Highly Cited
1998
Highly Cited
1998
Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram.
AIMS To evaluate disulfiram and three forms of manual guided psychotherapy for individuals with cocaine dependence and concurrent… Expand
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Highly Cited
1993
Highly Cited
1993
Generation of sodium-rich magmas from newly underplated basaltic crust
SODIUM-RICH rocks of trondhjemite–tonalite–dacite (TTD) or –granodiorite (TTG) suites form much of Precambrian continental crust1… Expand
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Highly Cited
1991
Highly Cited
1991
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects.
The role of human cytochrome P-450 IIE1 (P-450 IIE1) in the oxidation of a number of suspect carcinogens was examined by using a… Expand
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Highly Cited
1986
Highly Cited
1986
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study.
We conducted a controlled, blinded, multicenter study of disulfiram treatment of alcoholism in 605 men randomly assigned to 250… Expand
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Highly Cited
1982
Highly Cited
1982
Alcoholism treatment by disulfiram and community reinforcement therapy.
Traditional disulfiram treatment has often been ineffective because of a failure to maintain usage. The present study with 43… Expand
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Highly Cited
1972
Highly Cited
1972
The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme.
1. The ;xanthine oxidase' activity of rat liver supernatant, most of which behaves as an NAD(+)-dependent dehydrogenase (type D… Expand
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