Disulfiram

Known as: Disulfiram [Chemical/Ingredient], TTD, Disulfide, Tetraethylthiuram 
A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol… (More)
National Institutes of Health

Related topics

Related topics

40 relations
AcetaldehydeAlcoholic Intoxication, ChronicAmprenavirClavulanate
(More)

Broader (4)

Alcohol DeterrentsEmeticsThiocarbamatesdiethylthiocarbamate

Narrower (9)

AntabusAntabuseAnticolEWP 815
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
Background:Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer stem cells (CSCs) are a key mediator of… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Disulfiram reactivates latent HIV-1 in a Bcl-2-transduced primary CD4+ T cell model without inducing global T cell activation.
Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels to below the detection limit. However, due to the… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
Background:Previous studies indicate that disulfiram (DS), an anti-alcoholism drug, is cytotoxic to cancer cell lines and… (More)
  • figure 1
  • figure 1
  • figure 1
  • table 1
  • figure 2
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity.
Disulfiram (DSF), a member of the dithiocarbamate family capable of binding copper and an inhibitor of aldehyde dehydrogenase, is… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 3
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial.
CONTEXT Disulfiram has emerged as a promising treatment for cocaine dependence, but it has not yet been evaluated in general… (More)
  • figure 1
  • table 1
  • figure 2
  • table 2
  • table 3
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells.
The alcohol-abuse deterrent disulfiram (DSF) is shown to have a highly selective toxicity against melanoma in culture, inducing a… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram.
AIMS To evaluate disulfiram and three forms of manual guided psychotherapy for individuals with cocaine dependence and concurrent… (More)
Is this relevant?
Highly Cited
1992
Highly Cited
1992
Disulfiram treatment of alcoholism.
To assess the efficacy of supervised disulfiram as an adjunct to out-patient treatment of alcoholics, a randomised, partially… (More)
  • table 2
Is this relevant?
Highly Cited
1986
Highly Cited
1986
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study.
We conducted a controlled, blinded, multicenter study of disulfiram treatment of alcoholism in 605 men randomly assigned to 250… (More)
Is this relevant?
Highly Cited
1982
Highly Cited
1982
Alcoholism treatment by disulfiram and community reinforcement therapy.
Traditional disulfiram treatment has often been ineffective because of a failure to maintain usage. The present study with 43… (More)
  • table 1
  • figure 1
  • table 2
Is this relevant?