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Disulfiram

Known as: Disulfiram [Chemical/Ingredient], TTD, Disulfide, Tetraethylthiuram 
A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol… 
National Institutes of Health

Related topics

Related topics

42 relations
AcetaldehydeAlcoholic Intoxication, ChronicAmprenavirClavulanate

Broader (4)

Alcohol DeterrentsEmeticsThiocarbamatesdiethylthiocarbamate

Narrower (11)

AlcophobinAntabusAntabuseAnticol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes… 
Highly Cited
2017
Highly Cited
2017
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adapter NPL4
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A… 
Highly Cited
2013
Highly Cited
2013
Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram.
The combination of a chemotherapeutic drug with a multidrug resistance (MDR) modulator has emerged as a promising strategy for… 
Highly Cited
2011
Highly Cited
2011
Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
Background:Previous studies indicate that disulfiram (DS), an anti-alcoholism drug, is cytotoxic to cancer cell lines and… 
Review
2006
Review
2006
The Status of Disulfiram: A Half of a Century Later
Abstract: For more than 55 years, disulfiram has been approved by the Food and Drug Administration for the treatment of alcohol… 
Highly Cited
2006
Highly Cited
2006
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity.
Disulfiram (DSF), a member of the dithiocarbamate family capable of binding copper and an inhibitor of aldehyde dehydrogenase, is… 
Highly Cited
1993
Highly Cited
1993
Generation of sodium-rich magmas from newly underplated basaltic crust
SODIUM-RICH rocks of trondhjemite–tonalite–dacite (TTD) or –granodiorite (TTG) suites form much of Precambrian continental crust1… 
Review
1992
Review
1992
A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites
  • B. Johansson
  • Acta Psychiatrica Scandinavica Supplementum
  • 1992
  • Corpus ID: 23832065
After ingestion, disulfiram (DSF) is rapidly converted, probably in the stomach, to its bis (diethyldithiocarbamato) copper… 
Highly Cited
1986
Highly Cited
1986
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study.
We conducted a controlled, blinded, multicenter study of disulfiram treatment of alcoholism in 605 men randomly assigned to 250… 
Highly Cited
1972
Highly Cited
1972
The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme.
1. The ;xanthine oxidase' activity of rat liver supernatant, most of which behaves as an NAD(+)-dependent dehydrogenase (type D… 
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