Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 209,973,138 papers from all fields of science
Search
Sign In
Create Free Account
Disulfiram
Known as:
Disulfiram [Chemical/Ingredient]
, TTD
, Disulfide, Tetraethylthiuram
Expand
A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
42 relations
Acetaldehyde
Alcoholic Intoxication, Chronic
Amprenavir
Clavulanate
Expand
Broader (4)
Alcohol Deterrents
Emetics
Thiocarbamates
diethylthiocarbamate
Narrower (11)
Alcophobin
Antabus
Antabuse
Anticol
Expand
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2020
Highly Cited
2020
FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
J. Hu
,
Xing Liu
,
+15 authors
Hao Wu
Nature Immunology
2020
Corpus ID: 218495189
Cytosolic sensing of pathogens and damage by myeloid and barrier epithelial cells assembles large complexes called inflammasomes…
Expand
Highly Cited
2017
Highly Cited
2017
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adapter NPL4
Z. Skrott
,
M. Mistrik
,
+25 authors
J. Bartek
Nature
2017
Corpus ID: 205262686
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A…
Expand
Highly Cited
2013
Highly Cited
2013
Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram.
Xiaopin Duan
,
Jisheng Xiao
,
+4 authors
Yaping Li
ACS Nano
2013
Corpus ID: 37594254
The combination of a chemotherapeutic drug with a multidrug resistance (MDR) modulator has emerged as a promising strategy for…
Expand
Highly Cited
2011
Highly Cited
2011
Disulfiram modulated ROS–MAPK and NFκB pathways and targeted breast cancer cells with cancer stem cell-like properties
N. Yip
,
I. S. Fombon
,
+7 authors
W. Wang
British Journal of Cancer
2011
Corpus ID: 17040480
Background:Previous studies indicate that disulfiram (DS), an anti-alcoholism drug, is cytotoxic to cancer cell lines and…
Expand
Review
2006
Review
2006
The Status of Disulfiram: A Half of a Century Later
Jesse J. Suh
,
H. Pettinati
,
K. Kampman
,
C. O'brien
Journal of Clinical Psychopharmacology
2006
Corpus ID: 24202404
Abstract: For more than 55 years, disulfiram has been approved by the Food and Drug Administration for the treatment of alcohol…
Expand
Highly Cited
2006
Highly Cited
2006
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity.
Di Chen
,
Q. Cui
,
Huanjie Yang
,
Q. Dou
Cancer Research
2006
Corpus ID: 21075586
Disulfiram (DSF), a member of the dithiocarbamate family capable of binding copper and an inhibitor of aldehyde dehydrogenase, is…
Expand
Highly Cited
1993
Highly Cited
1993
Generation of sodium-rich magmas from newly underplated basaltic crust
M. Atherton
,
N. Petford
Nature
1993
Corpus ID: 4342740
SODIUM-RICH rocks of trondhjemite–tonalite–dacite (TTD) or –granodiorite (TTG) suites form much of Precambrian continental crust1…
Expand
Review
1992
Review
1992
A review of the pharmacokinetics and pharmacodynamics of disulfiram and its metabolites
B. Johansson
Acta Psychiatrica Scandinavica Supplementum
1992
Corpus ID: 23832065
After ingestion, disulfiram (DSF) is rapidly converted, probably in the stomach, to its bis (diethyldithiocarbamato) copper…
Expand
Highly Cited
1986
Highly Cited
1986
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study.
R. Fuller
,
L. Branchey
,
+7 authors
I. Lowenstam
JAMA
1986
Corpus ID: 24112663
We conducted a controlled, blinded, multicenter study of disulfiram treatment of alcoholism in 605 men randomly assigned to 250…
Expand
Highly Cited
1972
Highly Cited
1972
The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme.
E. Corte
,
F. Stirpe
Biochemical Journal
1972
Corpus ID: 33098451
1. The ;xanthine oxidase' activity of rat liver supernatant, most of which behaves as an NAD(+)-dependent dehydrogenase (type D…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE