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Disulfiram
Known as:
Disulfiram [Chemical/Ingredient]
, TTD
, Disulfide, Tetraethylthiuram
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A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol…
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National Institutes of Health
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Related topics
Related topics
42 relations
Acetaldehyde
Alcoholic Intoxication, Chronic
Amprenavir
Clavulanate
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Broader (4)
Alcohol Deterrents
Emetics
Thiocarbamates
diethylthiocarbamate
Narrower (11)
Alcophobin
Antabus
Antabuse
Anticol
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1985
1985
A one-year follow-up of men alcoholics given disulfiram.
Marc A. Schuckit
Journal of Studies on Alcohol
1985
Corpus ID: 9275282
A total of 348 consecutive primary alcoholics entering an alcoholism treatment program comprised Group 1 (172 men who were…
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1983
1983
Mechanism of inactivation of sheep liver cytoplasmic aldehyde dehydrogenase by disulfiram.
T. Kitson
Biochemical Journal
1983
Corpus ID: 28912051
Stoicheiometric amounts of [14C]disulfiram react rapidly with sheep liver cytoplasmic aldehyde dehydrogenase to give loss of…
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1982
1982
Involvement of a single thiol group in the conversion of the NAD+-dependent activity of rat liver xanthine oxidoreductase to the O2-dependent activity.
Z. Kamiński
,
M. Jeżewska
Biochemical Journal
1982
Corpus ID: 35011708
The effects of 2-iodosobenzoic acid, 4-chloromercuribenzoate, 5,5'-dithiobis-(2-nitrobenzoic acid) and…
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1977
1977
Cerebrospinal fluid homovanillic acid in male alcoholics: effects of disulfiram.
L. Major
,
J. Ballenger
,
F. Goodwin
,
G. L. Brown
Biological Psychiatry
1977
Corpus ID: 38638033
It is well know that if an individual maintained on disulfiram (Antabuse) ingests alcohol, excess acetaldehyde is formed…
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1977
1977
Inhibition of 1,2-dimethylhydrazine metabolism by disulfiram.
Emerich S. Fiala
,
George Bobotas
,
Callie Kulakis
,
J. Weisburger
Xenobiotica; the fate of foreign compounds in…
1977
Corpus ID: 1321304
1. The effects of disulfiram on the metabolism of 1,2-dimethylhydrazine were studied in CDF rats. 2. Treatment with disulfiram…
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Highly Cited
1976
Highly Cited
1976
Dietary constituents altering the responses to chemical carcinogens.
L. Wattenberg
,
W. D. Loub
,
Lu-Ke K. T. Lam
,
J. L. Speier
Federation proceedings
1976
Corpus ID: 21498636
This paper deals with two categories of compounds having the capacity to inhibit the neoplastic effects of chemical carcinogens…
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1975
1975
Isolation and structural studies of coprine, the disulfiram-like constituent of Coprinus atramentarius.
Hatfield Gm
,
Schaumberg Jp
1975
Corpus ID: 82972027
: Coprine, the constituent of the mushroom Coprinus atramentarius Fr. responsible for its disulfiram-like activity, was isolated…
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1972
1972
Blood Pressure Decreased by Halobutylpicolinic Acid, an Inhibitor of Dopamine β-Hydroxylase
H. Hidaka
,
K. Takeya
Nature
1972
Corpus ID: 4172371
THE isolation and purification of dopamine β-hydroxylase1,2 and the elucidation of the role in the biosynthesis of nor-adrenaline…
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1953
1953
An evaluation of the use of tetraethylthiuram disulfide in the treatment of 560 cases of alcohol addiction.
E. C. Hoff
,
Charles E. Mckeown
American Journal of Psychiatry
1953
Corpus ID: 42374449
Since the discoverv that tetraethvlthiurarn METHOD OF STUDY disulfide (TETD) (s a potent a&-alcohol drug, it has been used by…
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1951
1951
Therapeutic results and clinical manifestations following the use of tetraethylthiuram disulfide (antabuse).
George P. Child
,
W. Osinski
,
Robert E. Bennett
,
Eugene Davidoff
American Journal of Psychiatry
1951
Corpus ID: 26353483
The observations made during the treatment of 120 chronic alcoholics with Antabuse are reported. Certain animal experiments are…
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