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Disulfiram

Known as: Disulfiram [Chemical/Ingredient], TTD, Disulfide, Tetraethylthiuram 
A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol… 
National Institutes of Health

Related topics

Related topics

42 relations
AcetaldehydeAlcoholic Intoxication, ChronicAmprenavirClavulanate

Broader (4)

Alcohol DeterrentsEmeticsThiocarbamatesdiethylthiocarbamate

Narrower (11)

AlcophobinAntabusAntabuseAnticol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms.
Highly Cited
2004
Highly Cited
2004
Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial.
CONTEXT Disulfiram has emerged as a promising treatment for cocaine dependence, but it has not yet been evaluated in general… 
Highly Cited
1998
Highly Cited
1998
Mutations in the XPD helicase gene result in XP and TTD phenotypes, preventing interaction between XPD and the p44 subunit of TFIIH
In most cases, xeroderma pigmentosum group D (XP-D) and trichothiodystrophy (TTD) patients carry mutations in the carboxy… 
Review
1990
Review
1990
Antimutagenicity profiles for some model compounds.
Highly Cited
1980
Highly Cited
1980
Transition series metals and sulfhydryl reagents induce the synthesis of four proteins in eukaryotic cells.
Highly Cited
1979
Highly Cited
1979
Alcoholism and Treatment
The Rand report achieved coast to coast media coverage and generated a lot of heat simply because it was found that, out there in… 
Highly Cited
1977
Highly Cited
1977
Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes.
Highly Cited
1976
Highly Cited
1976
Improvements in the community-reinforcement approach to alcoholism.
Highly Cited
1975
Highly Cited
1975
Monoaminergic mechanisms of stimulation-produced analgesia
Highly Cited
1972
Highly Cited
1972
The regulation of rat liver xanthine oxidase. Involvement of thiol groups in the conversion of the enzyme activity from dehydrogenase (type D) into oxidase (type O) and purification of the enzyme.
1. The ;xanthine oxidase' activity of rat liver supernatant, most of which behaves as an NAD(+)-dependent dehydrogenase (type D… 
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