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Disulfiram

Known as: Disulfiram [Chemical/Ingredient], TTD, Disulfide, Tetraethylthiuram 
A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol… Expand
National Institutes of Health

Related topics

Related topics

42 relations
AcetaldehydeAlcoholic Intoxication, ChronicAmprenavirClavulanate
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Broader (4)

Alcohol DeterrentsEmeticsThiocarbamatesdiethylthiocarbamate

Narrower (11)

AlcophobinAntabusAntabuseAnticol
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adapter NPL4
Cancer incidence is rising and this global challenge is further exacerbated by tumour resistance to available medicines. A… Expand
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Highly Cited
2013
Highly Cited
2013
Smart pH-sensitive and temporal-controlled polymeric micelles for effective combination therapy of doxorubicin and disulfiram.
The combination of a chemotherapeutic drug with a multidrug resistance (MDR) modulator has emerged as a promising strategy for… Expand
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Review
2006
Review
2006
The Status of Disulfiram: A Half of a Century Later
Abstract: For more than 55 years, disulfiram has been approved by the Food and Drug Administration for the treatment of alcohol… Expand
Highly Cited
2006
Highly Cited
2006
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity.
Disulfiram (DSF), a member of the dithiocarbamate family capable of binding copper and an inhibitor of aldehyde dehydrogenase, is… Expand
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Highly Cited
2004
Highly Cited
2004
Efficacy of disulfiram and cognitive behavior therapy in cocaine-dependent outpatients: a randomized placebo-controlled trial.
CONTEXT Disulfiram has emerged as a promising treatment for cocaine dependence, but it has not yet been evaluated in general… Expand
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Highly Cited
1998
Highly Cited
1998
Treatment of cocaine and alcohol dependence with psychotherapy and disulfiram.
AIMS To evaluate disulfiram and three forms of manual guided psychotherapy for individuals with cocaine dependence and concurrent… Expand
Highly Cited
1993
Highly Cited
1993
Generation of sodium-rich magmas from newly underplated basaltic crust
SODIUM-RICH rocks of trondhjemite–tonalite–dacite (TTD) or –granodiorite (TTG) suites form much of Precambrian continental crust1… Expand
Highly Cited
1992
Highly Cited
1992
Disulfiram treatment of alcoholism.
To assess the efficacy of supervised disulfiram as an adjunct to out-patient treatment of alcoholics, a randomised, partially… Expand
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Highly Cited
1986
Highly Cited
1986
Disulfiram treatment of alcoholism. A Veterans Administration cooperative study.
We conducted a controlled, blinded, multicenter study of disulfiram treatment of alcoholism in 605 men randomly assigned to 250… Expand
Highly Cited
1982
Highly Cited
1982
Alcoholism treatment by disulfiram and community reinforcement therapy.
Traditional disulfiram treatment has often been ineffective because of a failure to maintain usage. The present study with 43… Expand
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