Disulfiram

Known as: Disulfiram [Chemical/Ingredient], TTD, Disulfide, Tetraethylthiuram 
A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol… (More)
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Background:Glioblastoma multiforme (GBM) cells are resistant to anticancer drugs. Cancer stem cells (CSCs) are a key mediator of… (More)
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Highly Cited
2011
Highly Cited
2011
Highly active antiretroviral therapy (HAART) can reduce plasma HIV-1 levels to below the detection limit. However, due to the… (More)
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Highly Cited
2011
Highly Cited
2011
Background:Previous studies indicate that disulfiram (DS), an anti-alcoholism drug, is cytotoxic to cancer cell lines and… (More)
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Highly Cited
2006
Highly Cited
2006
Disulfiram (DSF), a member of the dithiocarbamate family capable of binding copper and an inhibitor of aldehyde dehydrogenase, is… (More)
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Highly Cited
2004
Highly Cited
2004
CONTEXT Disulfiram has emerged as a promising treatment for cocaine dependence, but it has not yet been evaluated in general… (More)
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Highly Cited
2004
Highly Cited
2004
The alcohol-abuse deterrent disulfiram (DSF) is shown to have a highly selective toxicity against melanoma in culture, inducing a… (More)
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Highly Cited
1998
Highly Cited
1998
AIMS To evaluate disulfiram and three forms of manual guided psychotherapy for individuals with cocaine dependence and concurrent… (More)
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Highly Cited
1992
Highly Cited
1992
To assess the efficacy of supervised disulfiram as an adjunct to out-patient treatment of alcoholics, a randomised, partially… (More)
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Highly Cited
1986
Highly Cited
1986
We conducted a controlled, blinded, multicenter study of disulfiram treatment of alcoholism in 605 men randomly assigned to 250… (More)
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Highly Cited
1982
Highly Cited
1982
Traditional disulfiram treatment has often been ineffective because of a failure to maintain usage. The present study with 43… (More)
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