• Publications
  • Influence
The NPY system in stress, anxiety and depression
  • M. Heilig
  • Psychology, Medicine
  • Neuropeptides
  • 1 August 2004
NPY antagonizes behavioral consequences of stress through actions within the brain. Behavioral anti-stress actions of NPY are noteworthy in that (1) their magnitude surpasses that of other endogenousExpand
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Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms.
Alcoholism is a major public health problem and resembles, in many ways, other chronic relapsing medical conditions. At least 2 separate dimensions of its symptomatology offer targetableExpand
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Long‐lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol
Prolonged exposure of the brain to ethanol is a prerequisite for developing ethanol dependence, but the underlying neural adaptations are unknown. Here we demonstrate that rats subjected to repeatedExpand
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A key role for corticotropin-releasing factor in alcohol dependence
Recent data indicate that alcohol dependence induces long-term neuroadaptations that recruit a negative emotional state. This leads to excessive alcohol ingestion motivated by relief of negativeExpand
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A genetic determinant of the striatal dopamine response to alcohol in men
Excessive alcohol use, a major cause of morbidity and mortality, is less well understood than other addictive disorders. Dopamine release in ventral striatum is a common element of drug reward, butExpand
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Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression.
Exogenous neuropeptide Y (NPY) reduces experimental anxiety in a wide range of animal models. The generation of an NPY-transgenic rat has provided a unique model to examine the role of endogenous NPYExpand
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Neuroendocrine, Cognitive and Structural Imaging Characteristics of Women on Longterm Sickleave with Job Stress–Induced Depression
BACKGROUND A recent increase in long-term sick leave (LTSL) in Sweden affects mostly women in the public sector. Depression-related diagnoses account for most of the increase, and work-related stressExpand
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Anxiolytic-Like Action of Neuropeptide Y: Mediation by Y1 Receptors in Amygdala, and Dissociation from Food Intake Effects
Evidence from animal and human studies suggests that neuropeptide Y (NPY) may be a potent endogenous anxiolytic. The anatomic structures mediating this action of the peptide remain unknown.Expand
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REVIEW: Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?
The role of withdrawal‐related phenomena in the development and maintenance of alcohol addiction remains under debate. A ‘self‐medication’ framework postulates that emotional changes are induced by aExpand
  • 311
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Variation at the rat Crhr1 locus and sensitivity to relapse into alcohol seeking induced by environmental stress
Alcoholism is a chronic relapsing disorder with substantial heritability. Uncovering gene–environment interactions underlying this disease process can aid identification of novel treatment targets.Expand
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