• Publications
  • Influence
The NPY system in stress, anxiety and depression
  • M. Heilig
  • Medicine, Psychology
    Neuropeptides
  • 1 August 2004
TLDR
Information is provided on several brain structures involved in mediating anti-stress actions of NPY, with the most extensive evidence available for amygdala and hippocampus, and some evidence for regions within the septum, and locus coeruleus.
Upregulation of Voluntary Alcohol Intake, Behavioral Sensitivity to Stress, and Amygdala Crhr1 Expression Following a History of Dependence
TLDR
Alcohol drinking was upregulated long-term following a history of dependence and fear suppression of behavior was selectively potentiated in postdependent animals.
Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms.
TLDR
Feasibility of pharmacological treatment in alcoholism has been demonstrated by a first wave of drugs which consists of 3 currently approved medications, the aldehyde dehydrogenase blocker disulfiram, the opioid antagonist naltrexone (NTX) and the functional glutamate antagonist acamprosate (ACM).
A genetic determinant of the striatal dopamine response to alcohol in men
TLDR
It is reported that a functional OPRM1 A118G polymorphism is a major determinant of striatal dopamine responses to alcohol, a mechanism by which it likely modulates alcohol reward.
A key role for corticotropin-releasing factor in alcohol dependence
TLDR
The CRF system is emerging as a key element of the neuroadaptive changes driving alcoholism and as a major target for its treatment.
Anxiolytic-Like Action of Neuropeptide Y: Mediation by Y1 Receptors in Amygdala, and Dissociation from Food Intake Effects
TLDR
Activation of Yl receptors in the central nucleus of the amygdala produces effects similar to established anxiolytics without affecting food intake, suggesting that Yl-receptors in the amygdala may be a substrate for anxIOlytic actions of NPY.
Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression.
TLDR
Data obtained from the generation of an NPY-transgenic rat support and extend a previously postulated anti-stress action of NPY and provide novel evidence for a role ofNPY in learning and memory.
Neuroendocrine, Cognitive and Structural Imaging Characteristics of Women on Longterm Sickleave with Job Stress–Induced Depression
TLDR
An attenuated dex-CRH response in patients on LTSL due to job-stress related depression is opposite to what has been described in major depression.
REVIEW: Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?
TLDR
Emerging human data support the clinical relevance of negative emotionality for protracted abstinence and relapse and prompt a series of research questions.
Requirement of central ghrelin signaling for alcohol reward
TLDR
Central ghrelin signaling, via GHS-R1A, not only stimulates the reward system, but is also required for stimulation of that system by alcohol.
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