Monoaminergic mechanisms of stimulation-produced analgesia

@article{Akil1975MonoaminergicMO,
  title={Monoaminergic mechanisms of stimulation-produced analgesia},
  author={Huda Akil and John C. Liebeskind},
  journal={Brain Research},
  year={1975},
  volume={94},
  pages={279-296}
}

Pharmacological studies on stimulation-produced analgesia in mice.

  • W. R. Buckett
  • Biology, Psychology
    European journal of pharmacology
  • 1981

Serotonin involvement in descending inhibition of spinal nociceptive transmission produced by stimulation of medial diencephalon and basal forebrain

The results indicate that 5-HT may be involved in the mediation of spinal inhibition produced by medial diencephalic and basal forebrain stimulation in PCPA-pretreated cats.

Noradrenergic and serotonergic mediation of spinal analgesia mechanisms.

Noradrenalin, serotonin, and the dorsal horn.

Results indicate that noradrenalin facilitates the responses of dorsal horn cells to innocuous cutaneous stimuli, and has an inhibitory effect on the responses to noxious stimuli.

A pharmacologic study of analgesia produced by stimulation of the nucleus locus coeruleus

It is suggested that morphinergic, serotonergic, and alpha-adrenergic mechanisms mediate LC stimulation produced analgesia, which was absent in 6-OHDA-treated rats.
...

References

SHOWING 1-10 OF 54 REFERENCES

Evidence for dopamine receptor stimulation by apomorphine

Supporting evidence for apomorphine acts on the dopamine receptors whereas amphetamine acts by releasing dopamine is given by further functional, biochemical and histochemical studies.

Alpha adrenergic blocking agents: anti-nociceptive activity and enhancement of morphine-induced analgesia.

The results of these studies suggest that the actions of morphine and related narcoties may be associated with a reduction in norepinephrine's activity in the nervous system particularly at alpha adrenergic receptor sites.

p-Chlorophenylalanine: a specific depletor of brain serotonin.

  • B. KoeA. Weissman
  • Biology, Chemistry
    The Journal of pharmacology and experimental therapeutics
  • 1966
The results suggest that p -chlorophenylalanine may effect 5HT depletion by inhibiting the biosynthesis of this monoamine, possibly by blocking tryptophan hydroxylation.

Noradrenergic neurons: morphine inhibition of spontaneous activity.

BLOCKADE OF ENDOGENOUS NOREPINEPHRINE SYNTHESIS BY ALPHA-METHYL-TYROSINE, AN INHIBITOR OF TYROSINE HYDROXYLASE.

Preliminary studies of the pharmacologic consequences of blockade of norepinephrine synthesis indicate impairment of motor activity and mild sedation in cats and guinea pigs and a reduction of the tyramine and nore Pinephrine pressor responses in guinea pig and rats.

The effect of reserpine on transmission in the spinal cord.

In unanesthetized acute spinal cats, in which monoamine oxidase is inhibited, an i.v. injection of reserpine gives a profound depression of transmission from the flexor reflex afferents (FRA) to primary afferentS and motoneurones, similar to that evoked by the monoamhe precursors DOPA or 5-HTP.
...