Monoaminergic mechanisms of stimulation-produced analgesia

@article{Akil1975MonoaminergicMO,
  title={Monoaminergic mechanisms of stimulation-produced analgesia},
  author={Huda Akil and John C. Liebeskind},
  journal={Brain Research},
  year={1975},
  volume={94},
  pages={279-296}
}

• Huda Akil, John C. Liebeskind
• Published 1975 in Brain Research
• DOI:10.1016/0006-8993(75)90062-1

The roles played by the cerebral monoamines (dopamine, noradrenaline and serotonin) in stimulation-produced analgesia (SPA) have been investigated in the rat employing the tail flick test. SPA was elicited through bipolar electrodes chronically implanted in the mesencephalic periaqeductal gray matter, an area previously shown to yield potent and reliable analgesic effects. Four approaches were used to alter transmission in monoamine pathways. (1) Depletion of monoamines by administration of… CONTINUE READING

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