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Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
This work reorganized probes on more than a dozen popular GeneChips into gene-, transcript- and exon-specific probe sets in light of up-to-date genome, cDNA/EST clustering and single nucleotide polymorphism information, and demonstrates that the original Affymetrix probe set definitions are inaccurate.
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications
Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801.
The present studies suggest that NMDA receptors may be important in the development of opiate tolerance and dependence.
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Pattern and time course of immediate early gene expression in rat brain following acute stress
A selective role for dopamine in reward learning
Insight is provided into the neurobiology of a form of stimulus–reward learning that confers increased susceptibility to disorders of impulse control and in individuals with a propensity for this form of learning, reward cues come to powerfully motivate and control behaviour.
Anatomy of CNS opioid receptors
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
- P. Choudary, M. Molnar, E. Jones
- BiologyProceedings of the National Academy of Sciences…
- 17 October 2005
The astroglial distribution of the two glutamate transporters and l-glutamate-ammonia ligase strongly links glia to the pathophysiology of depression and challenges the conventional notion that depression is solely a neuronal disorder.
Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction
Genome-wide association study identifies 30 Loci Associated with Bipolar Disorder
The largest genome-wide association study to date, including 20,352 cases and 31,358 controls of European descent, with follow-up analysis of 881 sentinel variants at loci with P<1×10-4, achieves genome- wide significance including 18 novel loci, which provide potential new biological mechanisms for bipolar disorder.