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Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data
TLDR
This work reorganized probes on more than a dozen popular GeneChips into gene-, transcript- and exon-specific probe sets in light of up-to-date genome, cDNA/EST clustering and single nucleotide polymorphism information, and demonstrates that the original Affymetrix probe set definitions are inaccurate. Expand
Opioid-receptor mRNA expression in the rat CNS: anatomical and functional implications
TLDR
A broad anatomical maps of the three opioid-receptor mRNAs in relation to their binding sites is provided, and issues of receptor transport, trafficking and pre- versus postsynaptic localization are discussed. Expand
Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801.
TLDR
The present studies suggest that NMDA receptors may be important in the development of opiate tolerance and dependence. Expand
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
TLDR
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. Expand
A selective role for dopamine in reward learning
TLDR
Insight is provided into the neurobiology of a form of stimulus–reward learning that confers increased susceptibility to disorders of impulse control and in individuals with a propensity for this form of learning, reward cues come to powerfully motivate and control behaviour. Expand
Pattern and time course of immediate early gene expression in rat brain following acute stress
TLDR
The present results reveal a widespread pattern of neuronal activation in response to acute swim or restraint stress that may aid in the identification of stress-specific neural circuits and are likely to have important implications for the understanding of neuronal regulation of the stress response. Expand
Anatomy of an Endogenous Antagonist: Relationship between Agouti-Related Protein and Proopiomelanocortin in Brain
TLDR
Both AGRP and melanocortin neurons selectively express the MC3R, which provides a neuroanatomical basis for a dual-input circuit with biological amplification and feedback inhibition and highlights a broader complexity in POMC-mediated behavior in the brain. Expand
Anatomy of CNS opioid receptors
TLDR
There is a wide body of evidence to suggest the existence of at least three distinct opioid receptor types in the CNS, referred to as μ, δ, and κ, and their relation to the opioid peptides is discussed. Expand
Individual differences in the attribution of incentive salience to reward-related cues: Implications for addiction
TLDR
Preliminary data are reviewed suggesting that individual differences in the tendency to attribute incentive salience to cues predictive of reward may confer vulnerability or resistance to compulsive behavioral disorders, including addiction. Expand
Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression
TLDR
The astroglial distribution of the two glutamate transporters and l-glutamate-ammonia ligase strongly links glia to the pathophysiology of depression and challenges the conventional notion that depression is solely a neuronal disorder. Expand
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