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Diablo Homolog, Mitochondrial

Known as: DIABLO, Smac, Direct IAP-Binding Protein with Low pI 
Diablo homolog, mitochondrial (239 aa, ~27 kDa) is encoded by the human DIABLO gene. This protein plays a role in the activation of caspase-dependent… Expand
National Institutes of Health

Related topics

Related topics

11 relations
ApoptosisApoptosis PromoterCaspase ActivationCaspase Cascade Pathway
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
Toxic proteins released from mitochondria in cell death
A plethora of apoptotic stimuli converge on the mitochondria and affect their membrane integrity. As a consequence, multiple… Expand
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Highly Cited
2003
Highly Cited
2003
Direct Interaction between Survivin and Smac/DIABLO Is Essential for the Anti-apoptotic Activity of Survivin during Taxol-induced Apoptosis*
Survivin is a member of the inhibitor of apoptosis protein (IAP) family that has been implicated in both apoptosis inhibition and… Expand
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Highly Cited
2002
Highly Cited
2002
HtrA2 Promotes Cell Death through Its Serine Protease Activity and Its Ability to Antagonize Inhibitor of Apoptosis Proteins*
Inhibitor of apoptosis (IAP) proteins inhibit caspases, a function counteracted by IAP antagonists, insect Grim, HID, and Reaper… Expand
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Highly Cited
2002
Highly Cited
2002
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.
Recent reports suggest that a cross-talk exists between apoptosis pathways mediated by mitochondria and cell death receptors. In… Expand
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Highly Cited
2002
Highly Cited
2002
Proteasome-mediated Degradation of Smac during Apoptosis: XIAP Promotes Smac Ubiquitination in Vitro *
During apoptosis, Smac (secondmitochondria-derived activator ofcaspases)/DIABLO, an IAP (inhibitor of apoptosis protein)-binding… Expand
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Highly Cited
2001
Highly Cited
2001
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
X-linked inhibitor-of-apoptosis protein (XIAP) interacts with caspase-9 and inhibits its activity, whereas Smac (also known as… Expand
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Review
2001
Review
2001
Mechanisms of p53-dependent apoptosis.
Cellular stresses, such as growth factor deprivation, DNA damage or oncogene expression, lead to stabilization and activation of… Expand
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Highly Cited
2001
Highly Cited
2001
Apoptosis‐associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl‐2
Smac/DIABLO is a mitochondrial protein that potentiates some forms of apoptosis, possibly by neutralizing one or more members of… Expand
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Highly Cited
2000
Highly Cited
2000
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
Apoptosis (programmed cell death), an essential process in the development and homeostasis of metazoans, is carried out by… Expand
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Highly Cited
2000
Highly Cited
2000
Molecular Determinants of the Caspase-promoting Activity of Smac/DIABLO and Its Role in the Death Receptor Pathway*
Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and promotes cytochrome c… Expand
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