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Diablo Homolog, Mitochondrial
Known as:
DIABLO
, Smac
, Direct IAP-Binding Protein with Low pI
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Diablo homolog, mitochondrial (239 aa, ~27 kDa) is encoded by the human DIABLO gene. This protein plays a role in the activation of caspase-dependent…
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National Institutes of Health
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Related topics
Related topics
11 relations
Apoptosis
Apoptosis Promoter
Caspase Activation
Caspase Cascade Pathway
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
SMAC-armed vaccinia virus induces both apoptosis and necroptosis and synergizes the efficiency of vinblastine in HCC
Q. Pan
,
Yuanyong Huang
,
Lieyang Chen
,
Jin-fa Gu
,
Xiu-mei Zhou
Human Cell
2014
Corpus ID: 15060265
Hepatocellular carcinoma (HCC) has particularly high incidence rate in Asia and its resistance to the chemotherapeutic drugs and…
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2008
2008
The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila
F. S. Khan
,
M. Fujioka
,
P. Datta
,
T. Fernandes‐Alnemri
,
J. B. Jaynes
,
E. Alnemri
Cell Death and Differentiation
2008
Corpus ID: 440916
Mitochondrial proteins such as cytochrome c, Smac/DIABLO and Omi/HtrA2 play important roles in the cell death pathways of…
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2007
2007
The Aedes albopictus inhibitor of apoptosis 1 gene protects vertebrate cells from bluetongue virus‐induced apoptosis
Q. Li
,
H. Li
,
B. Blitvich
,
J. Zhang
Insect molecular biology (Print)
2007
Corpus ID: 32448417
We sequenced and characterized the inhibitor of apoptosis (iap) 1 gene from Aedes albopictus, designated as Aaiap1. The Aaiap1…
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Highly Cited
2004
Highly Cited
2004
Processed caspase‐2 can induce mitochondria‐mediated apoptosis independently of its enzymatic activity
J. Robertson
,
V. Gogvadze
,
A. Kropotov
,
H. Vakifahmetoglu
,
B. Zhivotovsky
,
S. Orrenius
EMBO Reports
2004
Corpus ID: 45569821
The mechanism by which caspase‐2 executes apoptosis remains obscure. Recent findings indicate that caspase‐2 is activated early…
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Highly Cited
2003
Highly Cited
2003
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather…
M. Rahmani
,
Chunrong Yu
,
+4 authors
S. Grant
Oncogene
2003
Corpus ID: 25876093
Effects of the PI-3 kinase inhibitor LY294002 (LY) have been examined in relation to responses of human leukemia cells to histone…
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Highly Cited
2003
Highly Cited
2003
A Novel Ubiquitin Fusion System Bypasses the Mitochondria and Generates Biologically Active Smac/DIABLO*
A. M. Hunter
,
D. Kottachchi
,
Jennifer Lewis
,
C. Duckett
,
R. Korneluk
,
P. Liston
Journal of Biological Chemistry
2003
Corpus ID: 6910597
Smac/DIABLO is a mitochondrial protein that is proteolytically processed and released during apoptosis along with cytochrome c…
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2003
2003
A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay.
C. J. Glover
,
K. Hite
,
+10 authors
R. Shoemaker
Analytical Biochemistry
2003
Corpus ID: 6646023
2003
2003
Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703.
L. Miao
,
Peng Yi
,
Yi Wang
,
Mian Wu
European Journal of Biochemistry
2003
Corpus ID: 33765455
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted much attention because of its ability to kill…
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Highly Cited
2002
Highly Cited
2002
Promotion of Photodynamic Therapy-Induced Apoptosis by the Mitochondrial Protein Smac/DIABLO: Dependence on Bax¶
J. Usuda
,
S. Chiu
,
+4 authors
N. Oleinick
Photochemistry and Photobiology
2002
Corpus ID: 36379051
Abstract Photodynamic therapy (PDT) using the second-generation photosensitizer phthalocyanine (Pc) 4 causes mitochondrial damage…
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2002
2002
Bryostatin 1 increases 1-beta-D-arabinofuranosylcytosine-induced cytochrome c release and apoptosis in human leukemia cells ectopically expressing Bcl-x(L).
Zhiliang Wang
,
Shujie Wang
,
Yun Dai
,
S. Grant
Journal of Pharmacology and Experimental…
2002
Corpus ID: 19612299
The ability of the protein kinase C down-regulator bryostatin 1 to potentiate 1-beta-D-arabinofuranosylcytosine (ara-C)-induced…
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