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Diablo Homolog, Mitochondrial

Known as: DIABLO, Smac, Direct IAP-Binding Protein with Low pI 
Diablo homolog, mitochondrial (239 aa, ~27 kDa) is encoded by the human DIABLO gene. This protein plays a role in the activation of caspase-dependent… 
National Institutes of Health

Related topics

Related topics

11 relations
ApoptosisApoptosis PromoterCaspase ActivationCaspase Cascade Pathway

Papers overview

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Highly Cited
2009
Highly Cited
2009
XIAP mediates NOD signaling via interaction with RIP2
NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved in sensing the presence of pathogens… 
Highly Cited
2005
Highly Cited
2005
Apoptotic Pathways Are Inhibited by Leptin Receptor Activation in Neutrophils1
Leptin regulates food intake as well as metabolic, endocrine, and immune functions. It exerts proliferative and antiapoptotic… 
Review
2004
Review
2004
Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology.
Highly Cited
2004
Highly Cited
2004
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function
Apollon (also known as BRUCE or BIRC6) is a large protein containing baculoviral-IAP-repeat (BIR) and ubiquitin-conjugating… 
Highly Cited
2002
Highly Cited
2002
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.
Recent reports suggest that a cross-talk exists between apoptosis pathways mediated by mitochondria and cell death receptors. In… 
Highly Cited
2002
Highly Cited
2002
Bcl-2 and Bcl-xL Inhibit CD95-mediated Apoptosis by Preventing Mitochondrial Release of Smac/DIABLO and Subsequent Inactivation of X-linked Inhibitor-of-Apoptosis Protein*
Bcl-2 and Bcl-xL are reported to inhibit CD95-mediated apoptosis in “type II” but not in “type I” cells. In the present studies… 
Highly Cited
2002
Highly Cited
2002
Rapid Kinetics of tBid-induced Cytochrome c and Smac/DIABLO Release and Mitochondrial Depolarization*
Cleavage of Bid has been shown to promote apoptosis by inducing mitochondrial membrane permeabilization with the resultant… 
Highly Cited
2001
Highly Cited
2001
Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by smac/DIABLO release from mitochondria.
In previous studies we have shown that the sensitivity of melanoma cell lines to tumor necrosis factor-related apoptosis-inducing… 
Highly Cited
2001
Highly Cited
2001
Apaf-1/Cytochrome c-independent and Smac-dependent Induction of Apoptosis in Multiple Myeloma (MM) Cells*
Smac, a second mitochondria-derived activator of caspases, promotes caspase activation in the cytochrome c(cyto-c)/Apaf-1/caspase… 
Highly Cited
2001
Highly Cited
2001
Diablo Promotes Apoptosis by Removing Miha/Xiap from Processed Caspase 9
MIHA is an inhibitor of apoptosis protein (IAP) that can inhibit cell death by direct interaction with caspases, the effector… 
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