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Diablo Homolog, Mitochondrial

Known as: DIABLO, Smac, Direct IAP-Binding Protein with Low pI 
Diablo homolog, mitochondrial (239 aa, ~27 kDa) is encoded by the human DIABLO gene. This protein plays a role in the activation of caspase-dependent… 
National Institutes of Health

Related topics

Related topics

11 relations
ApoptosisApoptosis PromoterCaspase ActivationCaspase Cascade Pathway

Papers overview

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2014
2014
SMAC-armed vaccinia virus induces both apoptosis and necroptosis and synergizes the efficiency of vinblastine in HCC
Hepatocellular carcinoma (HCC) has particularly high incidence rate in Asia and its resistance to the chemotherapeutic drugs and… 
2008
2008
The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila
Mitochondrial proteins such as cytochrome c, Smac/DIABLO and Omi/HtrA2 play important roles in the cell death pathways of… 
2007
2007
The Aedes albopictus inhibitor of apoptosis 1 gene protects vertebrate cells from bluetongue virus‐induced apoptosis
We sequenced and characterized the inhibitor of apoptosis (iap) 1 gene from Aedes albopictus, designated as Aaiap1. The Aaiap1… 
Highly Cited
2004
Highly Cited
2004
Processed caspase‐2 can induce mitochondria‐mediated apoptosis independently of its enzymatic activity
The mechanism by which caspase‐2 executes apoptosis remains obscure. Recent findings indicate that caspase‐2 is activated early… 
Highly Cited
2003
Highly Cited
2003
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather…
Effects of the PI-3 kinase inhibitor LY294002 (LY) have been examined in relation to responses of human leukemia cells to histone… 
Highly Cited
2003
Highly Cited
2003
A Novel Ubiquitin Fusion System Bypasses the Mitochondria and Generates Biologically Active Smac/DIABLO*
Smac/DIABLO is a mitochondrial protein that is proteolytically processed and released during apoptosis along with cytochrome c… 
2003
2003
A high-throughput screen for identification of molecular mimics of Smac/DIABLO utilizing a fluorescence polarization assay.
2003
2003
Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703.
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted much attention because of its ability to kill… 
Highly Cited
2002
Highly Cited
2002
Promotion of Photodynamic Therapy-Induced Apoptosis by the Mitochondrial Protein Smac/DIABLO: Dependence on Bax¶
Abstract Photodynamic therapy (PDT) using the second-generation photosensitizer phthalocyanine (Pc) 4 causes mitochondrial damage… 
2002
2002
Bryostatin 1 increases 1-beta-D-arabinofuranosylcytosine-induced cytochrome c release and apoptosis in human leukemia cells ectopically expressing Bcl-x(L).
The ability of the protein kinase C down-regulator bryostatin 1 to potentiate 1-beta-D-arabinofuranosylcytosine (ara-C)-induced… 
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