Diablo Homolog, Mitochondrial

Known as: DIABLO, Smac, Direct IAP-Binding Protein with Low pI 
Diablo homolog, mitochondrial (239 aa, ~27 kDa) is encoded by the human DIABLO gene. This protein plays a role in the activation of caspase-dependent… (More)
National Institutes of Health

Related topics

Related topics

11 relations
ApoptosisApoptosis PromoterCaspase ActivationCaspase Cascade Pathway
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Papers overview

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Highly Cited
2009
Highly Cited
2009
XIAP mediates NOD signaling via interaction with RIP2.
NOD1 and NOD2 are members of the NOD-like receptor (NLR) protein family that are involved in sensing the presence of pathogens… (More)
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Highly Cited
2005
Highly Cited
2005
X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO.
Members of the IAP (inhibitor of apoptosis) family function as anti-apoptotic proteins by binding directly to caspase-3, -7, and… (More)
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Review
2004
Review
2004
Caspases, IAPs and Smac/DIABLO: mechanisms from structural biology.
Caspases are the central component of the apoptotic machinery that irreversibly commits a cell to die. Whereas all caspases are… (More)
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Review
2004
Review
2004
Toxic proteins released from mitochondria in cell death
A plethora of apoptotic stimuli converge on the mitochondria and affect their membrane integrity. As a consequence, multiple… (More)
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Highly Cited
2003
Highly Cited
2003
A JNK-dependent pathway is required for TNFalpha-induced apoptosis.
Tumor necrosis factor (TNFalpha) receptor signaling can simultaneously activate caspase 8, the transcription factor, NF-kappaB… (More)
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Highly Cited
2002
Highly Cited
2002
Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro.
During apoptosis, Smac (second mitochondria-derived activator of caspases)/DIABLO, an IAP (inhibitor of apoptosis protein… (More)
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Highly Cited
2001
Highly Cited
2001
Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2.
Smac/DIABLO is a mitochondrial protein that potentiates some forms of apoptosis, possibly by neutralizing one or more members of… (More)
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Review
2001
Review
2001
Mechanisms of p53-dependent apoptosis.
Cellular stresses, such as growth factor deprivation, DNA damage or oncogene expression, lead to stabilization and activation of… (More)
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Highly Cited
2000
Highly Cited
2000
Structural and biochemical basis of apoptotic activation by Smac/DIABLO
Apoptosis (programmed cell death), an essential process in the development and homeostasis of metazoans, is carried out by… (More)
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Highly Cited
2000
Highly Cited
2000
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
Smac/DIABLO is a mitochondrial protein that is released along with cytochrome c during apoptosis and promotes cytochrome c… (More)
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