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DNA Interstrand Crosslinking

DNA Interstrand Crosslinking involves the formation of a covalent bond between two bases on different DNA strand. (NCI)
National Institutes of Health

Related topics

Related topics

4 relations
Chromosome StructuresDNA Crosslinking AgentDNA Interstrand Cross-Link RepairDNA Repair

Papers overview

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Highly Cited
1999
Highly Cited
1999
Phase separation in free-radical crosslinking copolymerization: formation of heterogeneous polymer networks
1998
1998
KW-2149 (7-N-[2-[gamma-L-glutamylamino]ethyldithioethyl] mitomycin C): DNA interactions and drug uptake following serum activation.
1995
1995
Repair analysis of 4-hydroperoxycyclophosphamide-induced DNA interstrand crosslinking in the c-myc gene in 4-hydroperoxycyclophosphamide-sensitive and-resistant medulloblastoma cell lines
Cyclophosphamide is one of the most active agents in the treatment of medulloblastoma. However, development of resistance to this… 
1995
1995
Labs online: research on the Internet.
Mitozolomide and its decomposition product MCTIC were found to be more cytotoxic to BE colon carcinoma cells in vitro than to HT… 
1990
1990
Discrepancy between cytotoxicity and DNA interstrand crosslinking of carboplatin and cisplatin in vivo
We used the method of alkaline elution to compare quantitatively the DNA lesions produced by cisplatin and carboplatin in the AKR… 
1990
1990
S1-nuclease enhancement of the ethidium bromide binding assay of drug-induced DNA interstrand crosslinking in human brain tumor cells.
1989
1989
Caffeine, aminoimidazolecarboxamide and dicoumarol, inhibitors of NAD(P)H dehydrogenase (quinone) (DT diaphorase), prevent both the cytotoxicity and DNA interstrand crosslinking produced by 5…
1985
1985
Specific DNA repair mechanisms may protect some human tumor cells from DNA interstrand crosslinking by chloroethylnitrosoureas but not from crosslinking by other anti-tumor alkylating agents.
In two recent reports we have shown that pretreatment of MER+ cells [cells proficient at: reactivating N-methyl-N'-nitro-N… 
1984
1984
The effects of X rays on BCNU-induced DNA crosslinking.
We have used the technique of alkaline elution to study DNA interstrand crosslinking in 9L rat brain tumor cells treated with… 
Highly Cited
1983
Highly Cited
1983
Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with…
Chloroethylnitrosoureas (CNU) are antitumor agents which produce DNA interstrand crosslinks. We have proposed that crosslinks are… 
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