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Tracking the Evolution of Non‐Small‐Cell Lung Cancer
Intratumor heterogeneity mediated through chromosome instability was associated with an increased risk of recurrence or death, a finding that supports the potential value of chromosome instability as a prognostic predictor.
Phylogenetic ctDNA analysis depicts early stage lung cancer evolution
It is shown that phylogenetic ct DNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies.
Defining the Roles of Nucleotide Excision Repair and Recombination in the Repair of DNA Interstrand Cross-Links in Mammalian Cells
A role for XPF and ERCC1 is defined in the excision of ICLs, but not in the recombinational components of cross-link repair, and homologous recombination but not nonhomologous end joining appears to play an important role in the repair of DSBs resulting from nitrogen mustard treatment.
Repair of Intermediate Structures Produced at DNA Interstrand Cross-Links in Saccharomyces cerevisiae
Examination of whole chromosomes from treated cells using contour-clamped homogenous electric field electrophoresis revealed the intermediate in the repair of ICLs in dividing cells, which are mostly in S phase, to be double-strand breaks (DSBs).
EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment.
It is shown that EGFR subcellular distribution can modulate DNA repair kinetics, with implications for design of EGFR-targeted combinational therapies.
Human SNM1A and XPF-ERCC1 collaborate to initiate DNA interstrand cross-link repair.
It is shown that purified human SNM1A (hSNM 1A), which exhibits a 5'-3' exonuclease activity, can load from a single DNA nick and digest past an ICL on its substrate strand.