DNA Interstrand Cross-Link Repair

Known as: Repair of DNA Interstrand Cross-Links 
DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce mutations, chromosomal rearrangements and cell death. A… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2017
0102019842017

Papers overview

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2015
2015
DNA interstrand cross-links (ICLs) prevent strand separation during DNA replication and transcription and therefore are extremely… (More)
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Highly Cited
2011
Highly Cited
2011
DNA interstrand cross-links (ICLs) are toxic DNA lesions whose repair in S phase of eukaryotic cells is incompletely understood… (More)
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2011
2011
One of the major DNA interstrand cross-link (ICL) repair pathways in mammalian cells is coupled to replication, but the… (More)
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Highly Cited
2010
Highly Cited
2010
Fanconi anemia (FA) is caused by mutations in 13 Fanc genes and renders cells hypersensitive to DNA interstrand cross-linking… (More)
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2010
2010
DNA interstrand cross-links (ICLs) are cytotoxic products of common anticancer drugs and cellular metabolic processes, whose… (More)
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Highly Cited
2009
Highly Cited
2009
Fanconi anemia is a human cancer predisposition syndrome caused by mutations in 13 Fanc genes. The disorder is characterized by… (More)
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2008
2008
DNA interstrand cross-links (ICLs) are highly cytotoxic DNA lesions hindering DNA replication and transcription. Whereas in… (More)
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2006
2006
Using a defined substrate DNA with a single psoralen interstrand cross-link (ICL), we studied the molecular mechanism of human… (More)
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Highly Cited
2001
Highly Cited
2001
DNA interstrand cross-links (ICLs) block the strand separation necessary for essential DNA functions such as transcription and… (More)
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Highly Cited
2000
Highly Cited
2000
The mechanisms by which DNA interstrand cross-links (ICLs) are repaired in mammalian cells are unclear. Studies in bacteria and… (More)
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