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DNA Interstrand Cross-Link Repair

Known as: Repair of DNA Interstrand Cross-Links 
DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce mutations, chromosomal rearrangements and cell death. A… 
National Institutes of Health

Related topics

Related topics

5 relations
Cell SurvivalDCLRE1B geneDCLRE1B protein, humanDCLRE1B wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Interplay between Fanconi anemia and homologous recombination pathways in genome integrity
The Fanconi anemia (FA) pathway plays a central role in the repair of DNA interstrand crosslinks (ICLs) and regulates cellular… 
Review
2014
Review
2014
Zein as a source of functional colloidal nano- and microstructures
Highly Cited
2012
Highly Cited
2012
BRCA1 and HSP90 cooperate in homologous and non-homologous DNA double-strand-break repair and G2/M checkpoint activation
Expression of functional breast cancer susceptibility gene 1 (BRCA1) in human breast and ovarian cancers is associated with… 
Highly Cited
2010
Highly Cited
2010
Cisplatin sensitivity of testis tumour cells is due to deficiency in interstrand-crosslink repair and low ERCC1-XPF expression
BackgroundCisplatin based chemotherapy cures over 80% of metastatic testicular germ cell tumours (TGCT). In contrast, almost all… 
Highly Cited
2007
Highly Cited
2007
The FANCJ/MutLα interaction is required for correction of the cross‐link response in FA‐J cells
FANCJ also called BACH1/BRIP1 was first linked to hereditary breast cancer through its direct interaction with BRCA1. FANCJ was… 
Review
2005
Review
2005
DNA Interstrand Crosslinks: Natural and Drug‐Induced DNA Adducts that Induce Unique Cellular Responses
It is a testimony to the complexity of cancer that cytotoxic drugs are still a mainstay of therapeutic approaches to treat that… 
Highly Cited
2004
Highly Cited
2004
The DNA crosslink‐induced S‐phase checkpoint depends on ATR–CHK1 and ATR–NBS1–FANCD2 pathways
The genetic syndrome Fanconi anemia (FA) is characterized by aplastic anemia, cancer predisposition and hypersensitivity to DNA… 
Highly Cited
2002
Highly Cited
2002
BRCA1 interacts directly with the Fanconi anemia protein FANCA.
Fanconi anemia (FA) is a rare autosomal recessive disease characterized by skeletal defects, anemia, chromosomal instability and… 
Review
2001
Review
2001
Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance.
Highly Cited
1994
Highly Cited
1994
Relationship between platinum-DNA adduct formation and removal and cisplatin cytotoxicity in cisplatin-sensitive and -resistant human ovarian cancer cells.
We examined several aspects of platinum-DNA adduct formation and repair in cisplatin-sensitive and -resistant human ovarian… 
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