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The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes.
TLDR
Colostrum may have value in enhancing athletic performance and preventing heat stroke, and in doing so may be a potential moderator of such effects. Expand
Bovine colostrum is a health food supplement which prevents NSAID induced gut damage
TLDR
Bovine colostrum could provide a novel, inexpensive approach for the prevention and treatment of the injurious effects of NSAIDs on the gut and may also be of value for the treatment of other ulcerative conditions of the bowel. Expand
Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration.
TLDR
Human spasmolytic polypeptide may play a key role in the early stages of mucosal repair by stimulating the initial re-epithelialization by cell migration. Expand
Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability.
TLDR
Preliminary evidence is provided that bovine colostrum, which is already currently available as an over-the-counter preparation, may provide a novel approach to the prevention of NSAID-induced gastrointestinal damage in humans. Expand
Human pancreatic secretory trypsin inhibitor stabilizes intestinal mucosa against noxious agents.
TLDR
Administration of PSTI may provide a novel method of stabilizing intestinal mucosa against noxious agents and stimulating repair after injury, and is dependent on the presence of a functioning EGF receptor. Expand
Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage.
TLDR
The hypothesis that trefoil peptides are important in stimulating gastrointestinal repair is supported by a transgenic mice strain that expresses human pS2 (hpS2) specifically within the jejunum and the effect of this overexpression on proliferation and susceptibility to indomethacin-induced damage is examined. Expand
Zinc carnosine, a health food supplement that stabilises small bowel integrity and stimulates gut repair processes
TLDR
ZnC, at concentrations likely to be found in the gut lumen, stabilises gut mucosa and is effective on various models of gut injury and repair, and in a clinical trial. Expand
Bioactivation of CB 1954: reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species.
TLDR
It is shown here that 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide can become a species capable of binding to DNA and producing interstrand crosslinks, by a direct, non-enzymatic reaction with either acetyl coenzyme A, butyl and propyl cofenzyme A or S-acetylthiocholine. Expand
Effects of mouse and human lipocalin homologues 24p3/lcn2 and neutrophil gelatinase-associated lipocalin on gastrointestinal mucosal integrity and repair.
TLDR
24p3/lcn2 facilitates mucosal regeneration by promoting cell migration and facilitates mucosa regeneration by facilitating cell migration in rats treated with indomethacin or dextran sodium sulfate treatment. Expand
Human Pancreatic Secretory Trypsin Inhibitor
TLDR
Findings suggest that PSTI may also be involved in both the early and late phases of the healing response following injury, and further studies including the production of transgenic overexpression and knockout models should help elucidate the physiological function of this peptide. Expand
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